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ChemicalBook >> CAS DataBase List >>N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Structure
N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride structure
CAS No.
2730-52-1
Chemical Name:
N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride
Synonyms
2,2,2-trifluoro-N-methylethan-1-amine hydrochloride;Upadacitinib Impurity 86 Hydrochloride;Methyl(2,2,2-trifluoroethyl)aMine, HCl;2,2,2-Trifluoro-N-MethylethanaMine HCl;N-Methyl-N-(2,2,2-trifluoroethyl)aMine HCl;2,2,2-TRIFLUORO-N-METHYLETHANAMINIUM CHLORIDE;N-Methyl-2,2,2-trifluoroethylamine Hydrochloride;N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride;2,2,2-trifluoro-N-methyl-Ethanamine hydrochloride (1:1);Ethanamine, 2,2,2-trifluoro-N-methyl-, hydrochloride (1:1)
CBNumber:
CB21552922
Molecular Formula:
C3H7ClF3N
Molecular Weight:
149.54
MDL Number:
MFCD08448126
MOL File:
2730-52-1.mol
MSDS File:
SDS
Last updated:2026-05-27 23:57:20
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N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Properties

Melting point >200 °C (sublm)(Solv: ethanol (64-17-5))
storage temp. Inert atmosphere,Room Temperature
form solid
color White
InChI InChI=1S/C3H6F3N.ClH/c1-7-2-3(4,5)6;/h7H,2H2,1H3;1H
InChIKey CUOWKFXFKFXJEL-UHFFFAOYSA-N
SMILES C(CNC)(F)(F)F.[H]Cl
UNSPSC Code 12352116
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P260-P280-P301+P312-P302+P352-P304+P340-P361+P364
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  2921199990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS001773 N-Methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride AldrichCPR 25 mg $77.9 2026-04-30 Buy
Apolloscientific PC450006 Methyl(2,2,2-trifluoroethyl)amine hydrochloride 98% 2730-52-1 1g $162 2026-06-04 Buy
Apolloscientific PC450006 Methyl(2,2,2-trifluoroethyl)amine hydrochloride 98% 2730-52-1 5g $573 2026-06-04 Buy
Apolloscientific PC450006 Methyl(2,2,2-trifluoroethyl)amine hydrochloride 98% 2730-52-1 10g $850 2026-06-04 Buy
Apolloscientific PC450006 Methyl(2,2,2-trifluoroethyl)amine hydrochloride 98% 2730-52-1 25g $1718 2026-06-04 Buy
Product number Packaging Price Buy
CDS001773 25 mg $77.9 Buy
PC450006 1g $162 Buy
PC450006 5g $573 Buy
PC450006 10g $850 Buy
PC450006 25g $1718 Buy

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Chemical Properties,Uses,Production

Synthesis

N-Methyl-2,2,2-trifluoroacetamide

815-06-5

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

2730-52-1

General procedure for the synthesis of N-methyl-2,2,2-trifluoroacetamide hydrochloride from N-methyl-2,2,2-trifluoroacetamide: A solution was prepared by dissolving lithium aluminum hydride (69 g, 1.8 mol) in 100 mL of ether at 100 °C. To this solution, an ether solution of 2,2,2-trifluoro-N-methylacetamide (86 g, 0.6 mol) was slowly added at 0 °C. The reaction mixture was stirred at room temperature overnight. Subsequently, sodium sulfate decahydrate was added to the mixture at -10°C and the resulting suspension was filtered. Dry HCl gas was passed into the filtrate until a white solid precipitated. The solid product was separated by filtration and recrystallized with a solvent mixture of methanol/ether to give N-methyl-2,2,2-trifluoroethylamine hydrochloride as a final white solid (73 g, 80.7% yield).

References

[1] Patent: WO2010/131145, 2010, A1. Location in patent: Page/Page column 76

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Preparation Products And Raw materials

Raw materials

N-Methyl-2,2,2-trifluoroacetamide Hydrochloric acid Lithium Aluminum Hydride Sodium sulfate Diethyl ether

Preparation Products

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Suppliers

Global( 71)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Hong-chuang Pharma Tech Co., Ltd. 18151128828 hc-sales@foxmail.com China 2635 55
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9849 55
Shanghai Carlow Chemicals Co., Ltd. 21-33526724 18930996265 info@carlowchem.com China 1996 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Xingui Biotechnology Co., Ltd. 15121041756 xingui2022@126.com China 9985 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Nanjing Chemlin Chemical Co., Ltd 64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
SynAsst Chemical. 55
Shanghai Hong-chuang Pharma Tech Co., Ltd. 55
Amatek Scientific Co. Ltd. 55
Shanghai Carlow Chemicals Co., Ltd. 58
Bide Pharmatech Ltd. 60
Shanghai Xingui Biotechnology Co., Ltd. 58

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Spectrum

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride(2730-52-1)1HNMR

2730-52-1(N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride)Related Search:

(3S)-(-)-3-(Trifluoroacetamido)pyrrolidine hydrochloride (S)-(-)-N-(Trifluoroacetyl)prolyl chloride 1-(3,4-Dichlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydro-3-pyridinecarboxamide 1-(2,6-Dichlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydro-3-pyridinecarboxamide 4-chloro-2-[(2,2,2-trifluoroacetyl)amino]benzenecarboxylic acid
1-(4-Chlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydro-3-pyridinecarboxamide N-[1-(2,6-Dichlorobenzyl)-2-oxo-1,2-dihydro-3-pyridinyl]-2,2,2-trifluoroacetamide 1-(3,4-Dichlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile Ethyl 2-(acetylamino)-2-chloro-3,3,3-trifluoropropanoate Ethyl 2-chloro-2-[(2,4-dichlorobenzoyl)amino]-3,3,3-trifluoropropanoate
Ethyl 2-chloro-2-[(2-chloroacetyl)amino]-3,3,3-trifluoropropanoate Ethyl 2-chloro-2-[(4-chlorobenzoyl)amino]-3,3,3-trifluoropropanoate Ethyl 2-chloro-2-[(3-chlorobenzoyl)amino]-3,3,3-trifluoropropanoate 2,3,3-Trichloro-1-[1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carbolin-2-yl]prop-2-en-1-one N1-(5-Chloro-4-fluoro-2-nitrophenyl)-2,2,2-trifluoroacetamide
1-(4-Chlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile Ethyl 2-chloro-2-[(ethoxycarbonyl)amino]-3,3,3-trifluoropropanoate Ethyl 2-chloro-3,3,3-trifluoro-2-(propionylamino)propanoate

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N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride 2,2,2-TRIFLUORO-N-METHYLETHANAMINIUM CHLORIDE Methyl(2,2,2-trifluoroethyl)aMine, HCl N-Methyl-N-(2,2,2-trifluoroethyl)aMine HCl 2,2,2-Trifluoro-N-MethylethanaMine HCl N-Methyl-2,2,2-trifluoroethylamine Hydrochloride Ethanamine, 2,2,2-trifluoro-N-methyl-, hydrochloride (1:1) 2,2,2-trifluoro-N-methyl-Ethanamine hydrochloride (1:1) Upadacitinib Impurity 86 Hydrochloride 2,2,2-trifluoro-N-methylethan-1-amine hydrochloride 2730-52-1