2-fluoro-5-methylpyridine-3-carboxylic acid
- CAS No.
- 1042986-00-4
- Chemical Name:
- 2-fluoro-5-methylpyridine-3-carboxylic acid
- Synonyms
- 2-Fluoro-5-Methylnicotinic acid;2-Fluoro-5-methylpyridine-3-carbxylic acid;2-fluoro-5-methylpyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2-fluoro-5-methyl-
- CBNumber:
- CB21558090
- Molecular Formula:
- C7H6FNO2
- Molecular Weight:
- 155.13
- MDL Number:
- MFCD11848712
- MOL File:
- 1042986-00-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P271-P261-P280 |
| HS Code | 2933399990 |
2-fluoro-5-methylpyridine-3-carboxylic acid price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | SRB98600 | 2-Fluoro-5-methylnicotinic Acid | 1042986-00-4 | 0.5g | $377.6 | 2026-06-05 | Buy |
| Biosynth | SRB98600 | 2-Fluoro-5-methylnicotinic Acid | 1042986-00-4 | 5g | $1770 | 2026-06-05 | Buy |
| Apolloscientific | PC535027 | 2-Fluoro-5-methylnicotinic acid 95% | 1042986-00-4 | 100mg | $64 | 2026-06-04 | Buy |
| Apolloscientific | PC535027 | 2-Fluoro-5-methylnicotinic acid 95% | 1042986-00-4 | 250mg | $109 | 2026-06-04 | Buy |
| Apolloscientific | PC535027 | 2-Fluoro-5-methylnicotinic acid 95% | 1042986-00-4 | 1g | $245 | 2026-06-04 | Buy |
2-fluoro-5-methylpyridine-3-carboxylic acid Chemical Properties, Uses, Production
Synthesis
2369-19-9
124-38-9
1042986-00-4
The general procedure for the synthesis of 2-fluoro-5-methylnicotinic acid from 2-fluoro-5-methylpyridine and carbon dioxide is as follows: 1. preparation of intermediate 8: a hexane solution of 1.6 M butyl lithium (28.13 ml, 45 mmol) was slowly added dropwise to a solution of diisopropylamine (6.36 ml, 45 mmol) in tetrahydrofuran (80 ml) at -78°C. After the dropwise addition was completed the mixture was slowly warmed up to 0°C and stirred for 10 minutes at this temperature. 2. the reaction mixture was re-cooled to -78°C and a solution of 2-fluoro-5-methylpyridine (4.64 ml, 45 mmol) in tetrahydrofuran (15 ml) was added slowly dropwise. 3. After stirring the reaction mixture at -78°C for 2 hours, the reaction was terminated by adding an excess of solid carbon dioxide. 4. The reaction mixture was slowly warmed to room temperature and then acidified with 10% citric acid solution and diluted with ethyl acetate. 5. The organic layer was separated, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuum to afford the target compound 2-fluoro-5-methylnicotinic acid as a white solid (4.9 g, 70% yield). 6. The product was characterized as 1H NMR (DMSO-d6, 400MHz) δ 2.34 (3H, s), 8.20-8.26 (2H, m); MS (ES+) 156, (ES-) 154.
References
[1] Organic Letters, 2018,
[2] Patent: WO2008/94992, 2008, A2. Location in patent: Page/Page column 171
2-fluoro-5-methylpyridine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
2-fluoro-5-methylpyridine-3-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
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| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Hebei Huaxing Chemical Co., Ltd | 0319-6931777 13930968617 | 630669494@qq.com | China | 1096 | 58 |
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