4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
- CAS No.
- 154590-35-9
- Chemical Name:
- 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
- Synonyms
- 4-(4-Boc-1-piperazinyl)-3-fluoroaniline;4-(4-Boc-piperazin-1-yl)-3-fluoroaniline;3-Fluoro-4-[4-(Boc-amino)piperidino]aniline;4-(4-Amino-2-fluorophenyl)-1-Boc-piperazine;4-(4-Boc-piperazin-1-yl)-3-fluoroaniline ISO 9001：2015 REACH;4-(4-Amino-2-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-(4-amino-2-fluorophenyl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB21562066
- Molecular Formula:
- C15H22FN3O2
- Molecular Weight:
- 295.35
- MDL Number:
- MFCD08443960
- MOL File:
- 154590-35-9.mol
- MSDS File:
- SDS
| Boiling point | 439.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.198±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | solid |
| pka | 6.67±0.10(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C15H22FN3O2/c1-15(2,3)21-14(20)19-8-6-18(7-9-19)13-5-4-11(17)10-12(13)16/h4-5,10H,6-9,17H2,1-3H3 |
| InChIKey | IULXQAJBODFBAK-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)C=C2F)CC1 |
| UNSPSC Code | 12352108 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P301+P312-P261 |
| HS Code | 2933599590 |
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC8788 | 4-(4-Amino-2-fluorophenyl)piperazine, N1-BOC protected 98% | 154590-35-9 | 250mg | $21 | 2026-06-04 | Buy |
| Synthonix | B66871 | tert-Butyl 4-(4-amino-2-fluorophenyl)tetrahydro-1(2H)-pyrazinecarboxylate >98% | 154590-35-9 | 1g | $40 | 2026-05-06 | Buy |
| Synthonix | B66871 | tert-Butyl 4-(4-amino-2-fluorophenyl)tetrahydro-1(2H)-pyrazinecarboxylate >98% | 154590-35-9 | 5g | $70 | 2026-05-06 | Buy |
| aablocks | AA00ABMB | tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 98% | 154590-35-9 | 100mg | $8 | 2026-05-28 | Buy |
| aablocks | AA00ABMB | tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 97% | 154590-35-9 | 250mg | $9 | 2026-05-28 | Buy |
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline Chemical Properties, Uses, Production
Synthesis
154590-34-8
154590-35-9
Preparation of 3-4-2: [3-Fluoro-4-(Boc-piperazinyl)]aniline To 150 mL of ethyl acetate were sequentially added 9.3 g (28.6 mmol) of tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate synthesized by the preparation of Example 3-4-1 and 930 mg (10 wt%) of Pd/C catalyst. The mixture was placed in a hydrogen reactor and reacted at 4 bar hydrogen pressure for 6 hours. Upon completion of the reaction, the Pd/C catalyst was removed by filtration. The filtrate was concentrated by distillation under reduced pressure and subsequently dried under vacuum at about 40 °C to give 8.22 g (yield: 97%) of the title compound. Mass spectrum (M + H)+: 296.11 1H-NMR (DMSO-d6) δ: 1.42 (s, 9H), 2.76 (br m, 4H), 3.43 (br m, 4H), 5.02 (s, 2H), 6.33 (m, 2H), 6.79 (m, 1H).
References
[1] Patent: US2011/306606, 2011, A1. Location in patent: Page/Page column 15
[2] Patent: EP2394993, 2011, A2. Location in patent: Page/Page column 23
[3] Patent: WO2005/82892, 2005, A2. Location in patent: Page/Page column 62-63
[4] Patent: WO2004/18439, 2004, A1. Location in patent: Page 31
[5] Patent: US2007/100141, 2007, A1. Location in patent: Page/Page column 27
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shanghaiaoderuikanglimitedcompany | 18902198068 18912886236 | akslichenglong@163.com | China | 592 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| AF Biochem Co., Ltd. | +86-028-60911900 13540204019 | sales@afbiochem.com | China | 479 | 57 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
View Latest Price from 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-02-02 | 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
154590-35-9
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
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- 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
154590-35-9
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
