tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate
- CAS No.
- 154590-34-8
- Chemical Name:
- tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate
- Synonyms
- 1-boc-4-(2-fluoro-4-nitrophenyl)piperazine;1-Boc-4-(2-Fluoro-4-nitrophenyl)piperazine,97%;1-Boc-4-(2-Fluoro-4-nitrophenyl)piperazine, 97%;4-(2-Fluoro-4-nitrophenyl)piperazine, N1-BOC protected;tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate;3-Fluoro-4-[4-(tert-butoxycarbonyl)piperazin-1-yl]nitrobenzene;1-Piperazinecarboxylic acid, 4-(2-fluoro-4-nitrophenyl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB11261843
- Molecular Formula:
- C15H20FN3O4
- Molecular Weight:
- 325.34
- MDL Number:
- MFCD08443959
- MOL File:
- 154590-34-8.mol
- MSDS File:
- SDS
| Melting point | 153-155 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| Boiling point | 453.5±45.0 °C(Predicted) |
| Density | 1.270±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | Solid |
| pka | 0.11±0.10(Predicted) |
| Appearance | Light yellow to yellow Solid |
| CAS DataBase Reference | 154590-34-8 |
tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC8776 | 4-(2-Fluoro-4-nitrophenyl)piperazine, N1-BOC protected 95% | 154590-34-8 | 250mg | $29 | 2026-06-04 | Buy |
| Apolloscientific | PC8776 | 4-(2-Fluoro-4-nitrophenyl)piperazine, N1-BOC protected 95% | 154590-34-8 | 1g | $44 | 2026-06-04 | Buy |
| Apolloscientific | PC8776 | 4-(2-Fluoro-4-nitrophenyl)piperazine, N1-BOC protected 95% | 154590-34-8 | 5g | $130 | 2026-06-04 | Buy |
| Apolloscientific | PC8776 | 4-(2-Fluoro-4-nitrophenyl)piperazine, N1-BOC protected 95% | 154590-34-8 | 10g | $221 | 2026-06-04 | Buy |
| Matrix Scientific | 046130 | tert-Butyl 4-(2-fluoro-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate | 154590-34-8 | 500.00mg | $181 | 2026-05-18 | Buy |
tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Chemical Properties, Uses, Production
Synthesis
24424-99-5
154590-33-7
154590-34-8
General procedure for the synthesis of tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate: 1. 1-(2-fluoro-4-nitrophenyl)piperazine (12.5 g, 55.8 mmol) was dissolved in 1,4-dioxane (108 mL) under cooling conditions in an ice bath. 2. 1N sodium hydroxide solution (54 mL) and di-tert-butyl dicarbonate (14 mL, 61.38 mmol) were added sequentially to the above solution. 3. The temperature of the reaction mixture was adjusted to 25-35°C and stirred continuously for 0.5 hours. 4. Upon completion of the reaction, the mixture was poured into ice-cold water (200 mL) and a yellow precipitate was precipitated. 5. The precipitate was collected by filtration through a Büchner funnel to afford the target product tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (18.0 g, 99% yield). Product characterization data: 1H NMR (CDCl3): δ 8.01-7.88 (m, 2H), 6.93 (t, J = 8.6 Hz, 1H), 3.61 (t, J = 4.9 Hz, 4H), 3.24 (t, J = 4.9 Hz, 4H), 1.49 (s, 9H). IR (KBr, cm-1): 3119, 1692, 1605, 1512. CI-MS (m/z): 326 (M++1), 270, 240, 226, 195, 183, 131, 96.
References
[1] Patent: WO2005/82892, 2005, A2. Location in patent: Page/Page column 61
[2] Patent: CN107033095, 2017, A. Location in patent: Paragraph 0085; 0086
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 19, p. 4261 - 4267
[4] Patent: US2004/220194, 2004, A1. Location in patent: Page 13; 14
[5] Patent: US2005/239795, 2005, A1. Location in patent: Page/Page column 18
tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Suppliers
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