Tenoxicam | 59804-37-4

Tenoxicam Properties

Melting point	209-2130C (dec)
Density	1.4737 (rough estimate)
refractive index	1.6390 (estimate)
storage temp.	2-8°C
solubility	Practically insoluble in water, sparingly soluble in methylene chloride, very slightly soluble in anhydrous ethanol. It dissolves in solutions of acids and alkalis.
pka	pKa1 5.3, pKa2 1.1(at 25℃)
form	Solid
color	White to Yellow to Green
Water Solubility	61.9mg/L(32 ºC)
Major Application	pharmaceutical pharmaceutical small molecule
InChI	InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
InChIKey	LZNWYQJJBLGYLT-UHFFFAOYSA-N
SMILES	S1(=O)(=O)C2C=CSC=2C(O)=C(C(NC2=NC=CC=C2)=O)N1C
CAS DataBase Reference	59804-37-4
EWG's Food Scores	1
FDA UNII	Z1R9N0A399
ATC code	M01AC02
UNSPSC Code	41116107
NACRES	NA.77

Pharmacokinetic data

Protein binding	99%
Excreted unchanged in urine	<1 (67% as metabolites and unchanged drug)
Volume of distribution	10-12 Litres
Biological half-life	72 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301+H311+H331

Precautionary statements

P280-P301+P310+P330-P302+P352+P312-P304+P340+P311

Hazard Codes

T,Xi

Risk Statements

23/24/25-36/37/38

Safety Statements

36/37/39-45-36-26-36/37

RIDADR

UN 2811 6.1/PG 3

WGK Germany

2

RTECS

XJ9095060

HS Code

2934.99.3000

HazardClass

6.1

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral

NFPA 704

	0
4		0

Tenoxicam price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T0909	Tenoxicam NSAID	59804-37-4	1g	$317	2026-04-30	Buy
Sigma-Aldrich	T0040800	Tenoxicam European Pharmacopoeia (EP) Reference Standard	59804-37-4	100 mg	$164	2026-04-30	Buy
Sigma-Aldrich	BP709	Tenoxicam degradation impurity standard British Pharmacopoeia (BP) Reference Standard	59804-37-4	25MG	$292	2026-04-30	Buy
Sigma-Aldrich	BP708	Tenoxicam British Pharmacopoeia (BP) Reference Standard	59804-37-4	100MG	$244	2026-04-30	Buy
Sigma-Aldrich	T0909	Tenoxicam NSAID	59804-37-4	5g	$1000	2023-06-20	Buy

Product number	Packaging	Price	Buy
T0909	1g	$317	Buy
T0040800	100 mg	$164	Buy
BP709	25MG	$292	Buy
BP708	100MG	$244	Buy
T0909	5g	$1000	Buy

Tenoxicam Chemical Properties,Uses,Production

Description

Tenoxicam is a non-steroidal antiinflammatory agent with a profile similar to related piroxicam and now withdrawn isoxicam (55). It is useful in the treatment of rheumatoid arthritis, osteoarthritis and related disorders.

Chemical Properties

Yellow Crystalline Powder

Originator

Hoffmann-La Roche (Switzerland)

Uses

Tenoxicam has been used:
    as a non-steroidal anti-inflammatory agent (NSAID) to study its effects on root gravitropism in Arabidopsis thaliana
    as a standard in microanalysis of NSAIDs by spectrophotometry
    to test its effect on surface potential andmembrane fluidity modification in phosphoglyceride monolayers

Definition

ChEBI: Tenoxicam is a thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is a heteroaryl hydroxy compound, a monocarboxylic acid amide, a member of pyridines and a thienothiazine.

brand name

Tilcotil

Biochem/physiol Actions

Tenoxicam (TX) possesses antipyreticand analgesic effects. It elicits radical scavenging activity and has the potential to treat enkylosing spondylitis, extra-articular diseases, acute gout, and rheumatic diseases. It is also effective in treating primary dysmenorrhea, postpartum uterine contraction pain, and post-operation backaches. TX is capable of inhibiting prostaglandin synthesis.

Clinical Use

NSAID and analgesic

Synthesis

The reaction of methyl 3-hydroxythiophene- 2-carboxylate with PCl5 in refluxing CCl4 gives 3-chlorothiophene-2-carboxylic acid, which by treatment with NaHSO3 and Cu in aqueous alkaline solution at 143 C in a pressure vessel is converted into 3- sulfothiophene-2-carboxylic acid. Its esterification with refluxing methanol affords methyl- 3-sulfothiophene-2-carboxylate, which by reaction with refluxing SOCl2 yields methyl- 3-chlorosulfonylthiophene-2-carboxylate. The following condensation with sarcosine ethyl ester in hot CHCl3 gives 3-(N-ethoxycarbonylmethyl- N-methylsulfamoyl)thiophene-2-carboxylate, which is cyclized by treatment with sodium methoxide in refluxing methanol affording 3-ethoxycarbonyl-4-hydroxy-2-methyl-2Hthieno--1,2-thiazine 1,1-dioxide. Finally this compound is condensed with 2-aminopyridine in refluxing toluene

Drug interactions

Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).
Antibacterials: possibly increased risk of convulsions with quinolones.
Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban - avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin concentration.
Antivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavir.
Ciclosporin: may potentiate nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect; hyperkalaemia with potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity.

Metabolism

Metabolised in the liver via cytochrome P450 2C9 to several pharmacologically inactive metabolites (mainly 5'-hydroxy-tenoxicam).
Metabolites are excreted mainly in the urine; there is some biliary excretion of glucuronide conjugates of the metabolites.

References

[1] Patent: CN106916169, 2017, A. Location in patent: Paragraph 0026; 0027; 0028; 0029

Tenoxicam synthesis

Synthesis of Tenoxicam from 2-Aminopyridine and Methyl 2-methyl-4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide

Tenoxicam Preparation Products And Raw materials

Raw materials

Ethyl 3-aminopropanoate hydrochloride 3-Chlorothiophene Sulfuryl chloride Methyl 3-hydroxythiophene-2-carboxylate 2-Aminopyridine

Sarcosine 2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide, 4-hydroxy-N-2-pyridinyl-, 1,1-dioxide Methyl 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide Methyl 2-methyl-4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide Dimethyl carbonate

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Preparation Products

Tenoxicam Suppliers

Global( 367)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei xingongli Chemical Co., Ltd	027-027-59106151 15172325309	1400858877@qq.com	China	9759	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7909	65

Supplier	Advantage
Hubei xingongli Chemical Co., Ltd	58
J & K SCIENTIFIC LTD.	76
INTATRADE GmbH	66
Energy Chemical	61
Jia Xing Isenchem Co.,Ltd	66
Adamas Reagent, Ltd.	59
LGM Pharma	70
Chemsky（shanghai）International Co.,Ltd.	50
XiaoGan ShenYuan ChemPharm co,ltd	52
Daicel Chiral Technologies (China)CO.,LTD	65

View Lastest Price from Tenoxicam manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	Tenoxicam 59804-37-4	1g	More Than 99%	50kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2026-09-11	Tenoxicam 59804-37-4	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-01	Tenoxicam 59804-37-4	1Kg	99%	10kg	Shaanxi TNJONE Pharmaceutical Co., Ltd

Tenoxicam
59804-37-4
$0.00
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Tenoxicam
59804-37-4
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Tenoxicam
59804-37-4
$0.00
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Tenoxicam Spectrum

Tenoxicam(59804-37-4)¹HNMR

59804-37-4(Tenoxicam)Related Search:

Chlorantraniliprole Meloxicam Bensulfuron methyl Methyl acrylate Benzamide

Piroxicam Lornoxicam Formamide Kresoxim-methyl 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine

Methylparaben Ampiroxicam Thiophanate-methyl N,N-Dimethylformamide Chlorophosphonazo III

Methyl 2-methyl-4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide Methyl 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide Methyl

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4-Hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide (Tenoxicam) MOBIFLEX tilcotil 3-Chlorosulfonyl-2-thiophene carboxylic acid methy Do1men 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2，3-e]-1，2-thiazine-3-carboxamidel，1-dioxide 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide 4-Hydroxy-2-methyl-N-2-pyrimidinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide 4-Hydroxy-2-methyl-3-[(2-pyridyl)carbamoyl]-2H-thieno[2,3-e][1,2]thiazine 1,1-dioxide 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-bisoxide 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide Epicotil OxaMen-L Soral TenoxicaM API 4-hydroxy-2-Methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1$l^{6},5,2-thieno[2,3-e][1$l^{6},2]thiazine-3-carboxaMide Tenoxicam Solution, 100ppm 1,1-dioxide-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide TENOXICAM 4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE AKOS 93347 3-e)-1,2-thiazine-3-carboxamide,4-hydroxy-2-methyl-n-2-pyridinyl-2h-thieno( 4-hydroxy-2-methyl-n-2-pyridinyl-2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide ro12-0068 TENATOPRAZOLESODIUM 4-Hydroxy-2-(methyl-d3)-N-(2-pyridyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide Tenoxicam-(methyl-d3) Tenoxicam (Mobiflex) 4-Hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide-1,1-dioxide TENOXICAM ASSAY STANDARD BP(CRM STANDARD) TENOXICAM BP STANDARD(CRM STANDARD) TENOXICAM EPT(CRM STANDARD) TenoxicamBp98 Alganex Dolmen Liman Rexalgan Tilatil 2H-Thieno(2,3-e)-1,2-thiyzin-3-carboxamid, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxid 69804-37-4 Tenoxicamum enoxicam Tenoxicam USP/EP/BP Lornoxicam Impurity 44 Mobiflex, Tenoxicam 6-chloro-4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3- carboxamide 1,1-dioxide Deschloro analog of lornoxicam/tenoxicam C17235000 Tenoxicam Tenoxicam, 10 mM in DMSO Tenoxicam - Bio-X ? Tenoxicam 99% Tenoxicam CRS Tinoprofen 59804-37-4 156-2-32 69804-37-4 9804-37-4 C13H11N3O4S2