Methyl 3-hydroxythiophene-2-carboxylate
- CAS No.
- 5118-06-9
- Chemical Name:
- Methyl 3-hydroxythiophene-2-carboxylate
- Synonyms
- Merhyl 3-hydroxy thiophene 2-carboxylate;Compound Fr14119;3-hydro-2-thiophenca;METHYL-3-HYDROXYTHIOPHENE CARBOXYLATE;Methyl-3-hydroxythiophen-2-carboxylat;3-Hydroxy-2-(methoxycarbonyl)thiophene;METHYL 3-HYDROXY-2-THIOPHENECARBOXYLATE;Methyl 3-hydroxythiophene-3-carboxylate;METHYL 3-HYDROXYTHIOPHENE-2-CARBOXYLATE;Methyl 3-hydroxythiophene-2-carboxylate ,97%
- CBNumber:
- CB7160233
- Molecular Formula:
- C6H6O3S
- Molecular Weight:
- 158.18
- MDL Number:
- MFCD00055642
- MOL File:
- 5118-06-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 38-43 °C(lit.) |
|---|---|
| Boiling point | 107-109°C 13mm |
| Density | 1.372±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 9.47±0.10(Predicted) |
| form | powder to crystal |
| color | White to Orange to Green |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C6H6O3S/c1-9-6(8)5-4(7)2-3-10-5/h2-3,7H,1H3 |
| InChIKey | SEMVRXMFCHXUMD-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)SC=CC=1O |
| CAS DataBase Reference | 5118-06-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Methyl 3-hydroxythiophene-2-carboxylate price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 566977 | Methyl 3-hydroxythiophene-2-carboxylate 97% | 5118-06-9 | 500mg | $95.9 | 2023-06-20 | Buy |
| TCI Chemical | M2716 | Methyl 3-Hydroxy-2-thiophenecarboxylate >97.0%(GC) | 5118-06-9 | 1g | $28 | 2026-04-30 | Buy |
| TCI Chemical | M2716 | Methyl 3-Hydroxy-2-thiophenecarboxylate >97.0%(GC) | 5118-06-9 | 5g | $85 | 2026-04-30 | Buy |
| Usbiological | 281600 | Methyl 3-hydroxythiophene-2-carboxylate Asreported | 5118-06-9 | 5g | $482 | 2026-06-03 | Buy |
| Usbiological | 281600 | Methyl 3-hydroxythiophene-2-carboxylate Asreported | 5118-06-9 | 10g | $701 | 2026-06-03 | Buy |
Methyl 3-hydroxythiophene-2-carboxylate Chemical Properties,Uses,Production
Uses
3-Hydroxy-2-thiophenecarboxylic Acid Methyl Ester, is used as a reactant in synthesizing nitro-products where reaction occurs with thiophenol.
Chemical Properties
white to light yellow crystal powder
Uses
Methyl 3-hydroxythiophene-2-carboxylate is used in medicine.
Synthesis Reference(s)
Synthetic Communications, 9, p. 731, 1979 DOI: 10.1080/00397917908064186
Synthesis
80-63-7
2365-48-2
5118-06-9
Methyl 3-hydroxy-2-thiophenecarboxylate was synthesized according to the method reported by Huddleston and Barker in Synth. Commun. 1979,9,8,731-734. The procedure was as follows: a 2 M solution of sodium methanol was prepared by adding sodium (700 mg; 30 mmol) to 15 mL of anhydrous methanol. Methyl mercaptoacetate (1.9 g; 18 mmol) was then added. The reaction solution was cooled to 0°C and methyl 2-chloroacrylate (2.1 g; 17.4 mmol) was added slowly and dropwise. The reaction mixture was stirred at room temperature overnight. After the reaction was complete, the mixture was cooled to 0°C again and the reaction was quenched with 4 M aqueous hydrochloric acid (~5 mL). Water was added and extracted twice with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2.0 g (70% yield) of brown oil, which solidified to a solid product after drying. The product could be used for subsequent reactions without further purification. The product was characterized as follows: LCMS m/z [M-H]-, retention time tR = 4.12 min, purity (UV/MS) 98/20; GCMS m/z 158 (M+), retention time tR = 4.52 min; 1H NMR (CDCl3, 400 MHz) δ 9.56 (br s, 1H, OH), 7.37 (d, 1H, J = 5.2 Hz, thiophene H), 6.74 (d, 1H, J = 5.2 Hz, thiophene H), 3.89 (s, 3H, OMe).
References
[1] Pesticide Science, 1996, vol. 48, # 4, p. 351 - 358
[2] Patent: WO2008/48648, 2008, A2. Location in patent: Page/Page column 70
[3] Helvetica Chimica Acta, 2002, vol. 85, # 12, p. 4485 - 4517
[4] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 20, p. 4333 - 4340
[5] Patent: US7452730, 2008, B2
Methyl 3-hydroxythiophene-2-carboxylate Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Lordaerun Medical Technology Co., LTD | 18968132030 | 414725184@qq.com | China | 171 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| ChangZhou SIDU chemical Co., Ltd. | 0519-81291281 18015082300 | siduchem@hotmail.com | China | 274 | 62 |
View Lastest Price from Methyl 3-hydroxythiophene-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Methyl 3-hydroxythiophene-2-carboxylate
5118-06-9
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-03-05 | 3-Hydroxythiophene-2-carboxylic acid methyl ester
5118-06-9
|
$786.00 | 1g | 98 | 5000 Kg | R&D Scientific Inc. | |
 |
2019-07-06 | Methyl 3-hydroxythiophene-2-carboxylate
5118-06-9
|
$8.00 | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- Methyl 3-hydroxythiophene-2-carboxylate
5118-06-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-Hydroxythiophene-2-carboxylic acid methyl ester
5118-06-9
- $786.00
- 98
- R&D Scientific Inc.
-
- Methyl 3-hydroxythiophene-2-carboxylate
5118-06-9
- $8.00
- 99%
- Career Henan Chemical Co
