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HA14-1

HA14-1 structure

CAS No.: 65673-63-4

Chemical Name:: HA14-1

Synonyms: CS-392;HA14-1;HA14-1/HA141;HA14-1 USP/EP/BP;HA14-1, 10 mM in DMSO;HA14-1;HA-14-1; HA 14-1;HA14-1, Bcl-2 inhibitor. BH-3 mimetic.;ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate;[Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate];2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester

CBNumber:: CB2170185

Molecular Formula:: C17H17BrN2O5

Molecular Weight:: 409.23

MDL Number:: MFCD00218213

MOL File:: 65673-63-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
HA 14-1 ≥98%	14876	5mg	$25
HA 14-1 ≥98%	14876	10mg	$48
HA14-1 Asreported	255434	10mg	$403
HA14-1 Asreported	255434	50mg	$1018
HA14-1 98.0%	CS-0138	5mg	$34
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HA14-1 Properties

Melting point	105 °C
Boiling point	535.114±50.00 °C(Press: 760.00 Torr)(predicted)
Density	1.480
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: 26 mg/mL
form	powder
pka	7.785±0.60(predicted)
color	White to light yellow
InChI	1S/C17H17BrN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
InChIKey	SXJDCULZDFWMJC-UHFFFAOYSA-N
SMILES	CCOC(=O)C(C#N)C1c2cc(Br)ccc2OC(N)=C1C(=O)OCC
CAS DataBase Reference	65673-63-4
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335

Precautionary statements

P280

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

HS Code

29322090

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

HA14-1 price More Price(74)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	14876	HA 14-1 ≥98%	65673-63-4	5mg	$25	2021-12-16	Buy
Cayman Chemical	14876	HA 14-1 ≥98%	65673-63-4	10mg	$48	2021-12-16	Buy
Usbiological	255434	HA14-1 Asreported	65673-63-4	10mg	$403	2026-06-03	Buy
Usbiological	255434	HA14-1 Asreported	65673-63-4	50mg	$1018	2026-06-03	Buy
ChemScene	CS-0138	HA14-1 98.0%	65673-63-4	5mg	$34	2026-06-04	Buy

Product number	Packaging	Price	Buy
14876	5mg	$25	Buy
14876	10mg	$48	Buy
255434	10mg	$403	Buy
255434	50mg	$1018	Buy
CS-0138	5mg	$34	Buy

HA14-1 Chemical Properties,Uses,Production

Uses

HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor.

Definition

ChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.

Biological Activity

Cell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells.

Biochem/physiol Actions

HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

Synthesis

105-56-6

1761-61-1

65673-63-4

GENERAL METHODS: 1,1,3,3-Tetramethylguanidine (TMG, 3.5 mmol) was added to a mixture of 5-bromosalicylaldehyde (SA, 1 mmol), ethyl cyanoacetate (MN, 1 mmol), and 2,3-diaminopyridine (DAP, 1 mmol) under pure conditions. The reaction mixture was stirred at room temperature and the reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, distilled water (15 mL) was added to the reaction mixture and stirring was continued until a free-flowing solid was formed. The solid was collected by filtration and washed sequentially with water and hexane. The crude product was purified by recrystallization from ethanol solution: the crude product was dissolved in boiling ethanol to saturation and hot filtered to remove undissolved solid. The hot filtrate was cooled to room temperature to give an elementally analytically pure crystalline product, rel-(αR,4R)-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-carbonyl)-4H-benzofuran-3-carboxylic acid. Similar experimental procedures were used to synthesize all 2-amino-4H-benzofuran derivatives.

in vivo

Swiss nude mice are challenged with BeGBM cells (10⁴ injected s.c.). HA14-1 (400 nmol) in 100 μL free RPMI 1640-50% DMSO, or the carrier alone, is given at the site of injection once weekly from day 2 following cell injection. HA14-1 treatment does not have any significant effect on the growth of glioblastoma tumors in immunodeficient mice as monitored twice weekly by measuring the volume of the expanding tumors. Moreover, no gross organ toxicity or weight loss can be detected in mice receiving such treatment. To analyze whether HA14-1 treatment might enhance the efficiency of another antitumoral treatment, Swiss nude mice challenged with human glioblastoma multiforme cells are also given i.p. low doses of Etoposide (2.5 mg/kg in 200 μL of 0.9% NaCl 5 days a week from day 2 following cell injection) together with HA14-1 or mock treatment. Whereas Etoposide treatment is insufficient by itself to restrain the growth of glioblastoma cells, its combination with HA14-1 leads to a significant restrain on tumor growth as judged by the ability of the combined treatment to increase the doubling time of the tumor volume^[3].

IC 50

Bcl-2: 9 μM (IC₅₀); Bcl-xL

References

[1] Tetrahedron Letters, 2005, vol. 46, # 20, p. 3497 - 3499
[2] RSC Advances, 2015, vol. 5, # 80, p. 65526 - 65531
[3] Tetrahedron, 2013, vol. 69, # 49, p. 10544 - 10551
[4] Tetrahedron Letters, 2006, vol. 47, # 43, p. 7629 - 7633
[5] Russian Chemical Bulletin, 2008, vol. 57, # 3, p. 595 - 600

HA14-1 synthesis

Synthesis of HA14-1 from Ethyl cyanoacetate and 5-Bromosalicylaldehyde

HA14-1 Preparation Products And Raw materials

Raw materials

5-Bromosalicylaldehyde Ethyl cyanoacetate Tetramethylguanidine

Preparation Products

HA14-1 Suppliers

Global( 152)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413	contact@trustwe.com	China	5742	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29096	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10378	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +8619957148339	market18@leapchem.com	China	24569	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9937	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
HANGZHOU LEAP CHEM CO., LTD.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

View Lastest Price from HA14-1 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	HA14-1 65673-63-4	$39.00-89.00		95.07%	10g	TargetMol Chemicals Inc.
	2019-07-06	HA14-1 65673-63-4	$2.00	1kg	99%	100kg	Career Henan Chemical Co

HA14-1
65673-63-4
$39.00-89.00
95.07%
TargetMol Chemicals Inc.

HA14-1
65673-63-4
$2.00
99%
Career Henan Chemical Co

HA14-1 Spectrum

HA14-1(65673-63-4)MS HA14-1(65673-63-4)¹HNMR

65673-63-4(HA14-1)Related Search:

3-(5-BROMO-2-METHOXYPHENYL)PROPANOIC ACID ETHYL 2-CYANOVALERATE 3-(2-METHOXYPHENYL)PROPIONIC ACID 3-Phenylglutaric acid 3-(3-Bromophenyl)propionic acid

Ethyl 2-cyanopropanoate METHYL 3-(2-HYDROXYPHENYL)PROPIONATE 3-(3-BROMOPHENYL)PROPIONITRILE 3-(3-Bromophenyl)-2-methylprop-1-ene HA14-1

ETHYL 2-CYANOBUTANOATE 3-(2-HYDROXY-PHENYL)-PROPIONIC ACID ETHYL ESTER ethyl 2-cyano-3-phenyl-propanoate 3-(3-BROMO-PHENYL)-PROPAN-1-OL 2-CYANO-3-PHENYLPROPIONIC ACID

3-(5-bromo-2-methoxy-phenyl)propionitrile 2-Cyano-pentanedioic acid diethyl ester 3-(2-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

1of4

2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(4H)-1-benzopyrane-4-aceticacidethylester ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester, Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate [Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate], Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate CS-392 Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate 97% HA 14-1, Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate, 2-[2-Amino-6-bromo-3-(ethoxycarbonyl)-4H-chromen-4-yl]-3-ethoxy-3-oxopropanenitrile (R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester HA 14-1 HA 14-1 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester [Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate] Ethyl2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate97% HA14-1;HA-14-1; HA 14-1 ethyl (4S)-2-amino-6-bromo-4-[(R)-cyano-ethoxycarbonyl-methyl]-4H-chromene-3-carboxylate HA14-1 ETHYL [2-AMINO-6-BROMO-4-(1-CYANO-2-ETHOXY-2-OXOETHYL)]-4H-CHROMENE-3-CARBOXYLATE 2-AMINO-6-BROMO-ALPHA-CYANO-3-(ETHOXYCARBONYL)-4H-1-BENZOPYRAN-4-ACETIC ACID ETHYL ESTER 4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester, (αR,4R)-rel- HA14-1 USP/EP/BP rel-(R)-Ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate(relative) rel-Ethyl (αR,4R)-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetate HA14-1/HA141 HA14-1, Bcl-2 inhibitor. BH-3 mimetic. HA14-1, 10 mM in DMSO 65673-63-4 C17H17BrN2O5 Apoptosis and Cell Cycle BioChemical Cell Biology Apoptosis Inducers Cell Signaling and Neuroscience Inhibitors Caspases/Apoptosis Inhibitor