Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Pivaldehyde

Pivaldehyde

Pivaldehyde Structure
Pivaldehyde structure
CAS No.
630-19-3
Chemical Name:
Pivaldehyde
Synonyms
PIVALALDEHYDE;PAL;TRIMETHYLACETALDEHYDE;2,2-DIMETHYLPROPANAL;Pivalic aldehyde;tert-Pentanal;2,2-dimethyl-propana;propanal,2,2-dimethyl-;LRIT1;LRRC21
CBNumber:
CB2174507
Molecular Formula:
C5H10O
Molecular Weight:
86.13
MDL Number:
MFCD00006962
MOL File:
630-19-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:59:14
Request For Quotation

Pivaldehyde Properties

Melting point 6 °C(lit.)
Boiling point 74 °C730 mm Hg(lit.)
Density 0.793 g/mL at 25 °C(lit.)
refractive index n20/D 1.378(lit.)
Flash point 4 °F
storage temp. 2-8°C
solubility Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
form Liquid
color Clear colorless
Specific Gravity 0.793
Water Solubility Negligible
Sensitive Air Sensitive
BRN 506060
Henry's Law Constant 4.1×10-2 mol/(m3Pa) at 25℃, Wang et al. (2017)
Dielectric constant 9.0500000000000007
Stability Air Sensitive, Volatile
InChI 1S/C5H10O/c1-5(2,3)4-6/h4H,1-3H3
InChIKey FJJYHTVHBVXEEQ-UHFFFAOYSA-N
SMILES [H]C(=O)C(C)(C)C
CAS DataBase Reference 630-19-3(CAS DataBase Reference)
FDA UNII SSC20260QW
NIST Chemistry Reference Propanal, 2,2-dimethyl-(630-19-3)
EPA Substance Registry System Propanal, 2,2-dimethyl- (630-19-3)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H315-H319-H335
Precautionary statements  P210-P233-P240-P241-P303+P361+P353-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  F,Xi,F+
Risk Statements  11-37/38-43
Safety Statements  16-23-33-24
RIDADR  UN 1989 3/PG 2
WGK Germany  3
F  8
TSCA  TSCA listed
HazardClass  3
PackingGroup  III
HS Code  29121900
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
3
2 0

Pivaldehyde price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T71501 Trimethylacetaldehyde 96% 630-19-3 5ml $72.1 2026-04-30 Buy
Sigma-Aldrich T71501 Trimethylacetaldehyde 96% 630-19-3 25ml $263 2026-04-30 Buy
TCI Chemical P0847 Pivalaldehyde >95.0%(GC) 630-19-3 5mL $50 2026-04-30 Buy
TCI Chemical P0847 Pivalaldehyde >95.0%(GC) 630-19-3 25mL $146 2026-04-30 Buy
Usbiological 567529 LRIT1 PurifiedbyProteinGaffinitychromatography 50ul $509 2026-06-03 Buy
Product number Packaging Price Buy
T71501 5ml $72.1 Buy
T71501 25ml $263 Buy
P0847 5mL $50 Buy
P0847 25mL $146 Buy
567529 50ul $509 Buy

Pivaldehyde Chemical Properties, Uses, Production

Description

Trimethylacetaldehyde (also known as Pivaldehyde) is the trimethyl form of acetaldehyde. It is an aldehyde with a sterically bulky R group, the tertiary-butyl group being attached to the carbonyl, >C=O. It is a useful reagent in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. It is useful in streoselective synthesis application as well as in aldol condensation reactions. As a derivative of acetaldehyde, trimethyl acetaldehyde can be used for the production of acetate. It can also be used as the precursor for manufacturing of pyridine derivatives, pentaerythritol, and crotonaldehyde.

Chemical Properties

Clear colorless liquid

Uses

Commonly used building block in aldol condensation reactions.

Uses

Trimethylacetaldehyde is used as a stereoselective synthesis application. It is also used as a building block used in aldol condensation reactions. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.

Definition

ChEBI: 2,2-dimethylpropanal is a member of the class of propanals that is propanal substituted by two methyl groups at position 2. It is a member of propanals and a 2-methyl-branched fatty aldehyde.

Application

Pivaldehyde is a hazardous by-product released from engine exhaust and is often used as a raw material for organic synthesis or as a reagent in chemical reactions. It can be copolymerised with aldehyde anions, such as acrolein, to prepare unsaturated polyacetals, or a TBPB initiated decarbonylative cascade cyclization of ortho-cyanoarylacrylamides with pivaldehyde leads to tert-butyl containing quinolone-2,4(1H,3H)-diones by formation of both C(sp3)–C(sp3) and C(sp3)–C(sp2) bonds. As well as probing the absolute rate constants of its autoxidation, etc[1-3].

Synthesis

Pivaloyl chloride was used as raw material, palladium-carbon poisoned by quinoline-S was used as catalyst, and the reduction reaction was carried out with hydrogen in a solvent to which an acid-binding agent was added, and the reaction solution was sequentially filtered, washed, extracted, dried and distilled to obtain pivaloyl aldehyde.

References

[1] A. LAPENA R. S J L Mateo. Anionic copolymerization of acrolein with aldehydes. III[J]. Journal of Polymer Science: Polymer Symposia, 1973, 42 1: 311-319. DOI:10.1002/polc.5070420133.
[2] CUI ZHANG. Decarbonylative cascade cyclization of ortho-cyanoarylacrylamides with pivaldehyde: Access to tert-butyl containing quinolone-2,4(1H,3H)-diones[J]. Tetrahedron, 2022. DOI:10.1016/j.tet.2021.132547.
[3] G. ZAIKOV K. I J Howard. Absolute rate constants for hydrocarbon autoxidation. XIII. Aldehydes: photo-oxidation, co-oxidation, and inhibition[J]. Canadian Journal of Chemistry, 1969. DOI:10.1139/V69-500.
[4] Ho, Tse Lok, et al. Pivaldehyde. Fieser and Fieser's Reagents for Organic Synthesis. John Wiley & Sons, Inc. 2006.
[5] https://en.wikipedia.org/wiki/Acetaldehyde#Uses
[6] https://en.wikipedia.org/wiki/Pivaldehyde
[7] https://www.alfa.com/en/catalog/A15013/
[8] GEORGE A. OLAH. Acid-Catalyzed Isomerization of Pivalaldehyde to Methyl Isopropyl Ketone via a Reactive Protosolvated Carboxonium Ion Intermediate[J]. Journal of the American Chemical Society, 2001, 123 47: 11556-11561. DOI:10.1021/ja011253a.
[9] O. SUGIMOTO. Preparation and reaction of quinolinyl (or pyridinyl)phosphonium salts with base and pivalaldehyde[J]. Heterocycles, 2011, 56 1: 837-847. DOI:10.3987/COM-11-12154.
[10] SUNG MAN PARK Chan H K Yu Ran Lee. Conformational Structures of Neutral and Cationic Pivaldehyde Revealed by IR-Resonant VUV-MATI Mass Spectroscopy.[J]. International Journal of Molecular Sciences, 2022, 23 23. DOI:10.3390/ijms232314777.

Pivaldehyde synthesis

14691-89-5
75-84-3
630-19-3
Synthesis of Pivaldehyde from 4-ACETAMIDO-TEMPO and NEOPENTYL ALCOHOL

Pivaldehyde Preparation Products And Raw materials

Raw materials

3,3-Dimethyl-2-oxobutyric acid 2-hydroxy-2-methylpropionaldehyde

Preparation Products

Clomazone neopentyl glycol (S)-2-Methylproline Methyl isocyanoacetate N-(Trimethylsilyl)-2,2-dimethylpropane-1-imine
2,2-Dimethyl-3-hexanol 1,9-Bis-Boc-1,5,9-triazanonane methyl (2S)-2-amino-3,3-dimethylbutanoate 2,2-Dimethyl-3-hexanone (2S,5S)-(-)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone
Ethyl pivaloylacetate 2-Amino-5-tert-butyl-1,3,4-thiadiazole 2R,5S)-5-benzyl-2-tert-butyl-3-MethyliMidazolidin-4-one

1of3

Pivaldehyde Suppliers

Global Suppliers ( 412)
Supplier Tel Email Country ProdList Advantage
Shaoxing Zhonglei New Materials Co., Ltd 0575-82040869 13346048991 sales@catsyn.com China 1 58
XIANAONARUNNEWMATERIALCo.,Ltd 029-81509060 13629280593 2074901304@qq.com China 185 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Henan Alpha Chemical Co., Ltd. 0371-55055611 18137792234 3957071458@qq.com China 9959 58
XPERTICK (SHANDONG) BIO-PHARMACEUTICAL CO., LTD 21-58999881 15623240527 emily@xtick.cn China 61 58
Xi'an Qingxiang Biotechnology Co., Ltd 029-18192656670 18192656670 2557411153@qq.com China 189 58
NANJING SHUNXIANG PHARMACEUTICAL TECHNOLOGY CO.,LTD. 025-86819868 13951004015 sales@jinchemical.com China 26 58
Xi 'an billiton biological technology co., LTD 029-88764766 wang.yali@xatuochao.com China 521 58
Handan Huajun Chemicals Co., Ltd. 13303008150; 13303008150 884971191@qq.com China 20 55
Hubei Shishun Biotechnology Co. Ltd 027-59223025 15107168801 1718480011@qq.com China 9401 58
Supplier Advantage
Shaoxing Zhonglei New Materials Co., Ltd 58
XIANAONARUNNEWMATERIALCo.,Ltd 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Henan Alpha Chemical Co., Ltd. 58
XPERTICK (SHANDONG) BIO-PHARMACEUTICAL CO., LTD 58
Xi'an Qingxiang Biotechnology Co., Ltd 58
NANJING SHUNXIANG PHARMACEUTICAL TECHNOLOGY CO.,LTD. 58
Xi 'an billiton biological technology co., LTD 58
Handan Huajun Chemicals Co., Ltd. 55
Hubei Shishun Biotechnology Co. Ltd 58

Related articles

Related Questions

Ask a question
Q:What is the connection between pivaldehyde and crotonaldehyde?STAR - Mar 20,2026
A:Pivaldehyde and Crotonaldehyde are both important aliphatic aldehyde intermediates used in the preparation of certain pesticides and herbicides. Pivaldehyde is a highly branched, saturated aldehyde, an α-branched aldehyde with significant steric hindrance; while Crotonaldehyde is an unsaturated, straight-chain aldehyde with a conjugated system, readily undergoing addition reactions. In industrial synthesis, Pivaldehyde provides a stable tert-butyl steric structure, while Crotonaldehyde provides conjugated double bond active sites.
Q:What is the boiling point of pivaldehyde?STAR - Mar 20,2026
A:Pivaldehyde (CAS No.: 630-19-3) is an aldehyde reaction substrate with a purity of 98%. It is volatile and typically has a boiling point in the range of 74–76 °C (165–169 °F; 347–349 K), with a boiling point of 74 °C at 730 mm Hg and 77.5 °C at 760 mm Hg.

View Latest Price from Pivaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pivalaldehyde pictures 2026-09-17 Pivalaldehyde
630-19-3
 $190.00 1kg 96.0% 500MT Handan Huajun chemicals Co.,Ltd
Pivaldehyde pictures 2026-09-15 Pivaldehyde
630-19-3
 1kg 96% 1 Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.
Pivaldehyde pictures 2026-08-20 Pivaldehyde
630-19-3
 $1.10 1g 99.9% 100 Tons Min Dideu Industries Group Limited
  • Pivaldehyde pictures
  • Pivaldehyde
    630-19-3
  • $0.00
  • 96%
  • Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.
  • Pivaldehyde pictures
  • Pivaldehyde
    630-19-3
  • $1.10
  • 99.9%
  • Dideu Industries Group Limited

Pivaldehyde Spectrum

Pivaldehyde(630-19-3)MSPivaldehyde(630-19-3)1HNMRPivaldehyde(630-19-3)13CNMRPivaldehyde(630-19-3)IR1Pivaldehyde(630-19-3)Raman

630-19-3 (Pivaldehyde) Related Search:

PotassiuM triMethylacetate Trimethylacetic anhydride Iodomethyl pivalate Trimethylacetonitrile Pivalic acid
Neopentylamine Pivaloyl chloride 1-Phenyl-1-cyclopropanecarboxylic acid 1-Bromopinacolone Diethyl 1,1-cyclopropanedicarboxylate
tert-Butanol Propionaldehyde Trimethylacetaldehyde oxime Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)dysprosium(III) Pr(TMHD)3
Tetramethyl-1,3-cyclobutanedione Chloromethyl pivalate 2,2-Dimethyl-6,6,7,7,8,8,8-heptafluoro-3,5-octanedione Trimethylacetaldehyde

1of4

PIVALDEHYDE 2,2-Dimethylpropionaldehyd 2-Dimethylpropanal alpha,alpha-Dimethylpropionaldehyde Neopentaldehyde Neopentanal Pivalic aldehyde Pivalicaldehyde propanal,2,2-dimethyl- tert-Butylformaldehyde tert-C4H9CHO tert-Pentanal tert-Valeraldehyde Trimethylacetaldehyd α,α-Dimethylpropanal α,α-Dimethylpropionaldehyde 2,2-DIMETHYLPROPIONALDEHYDE 2,2-DIMETHYL-1-PROPANAL Pivaldehyde, 97%, AcroSeal Three Methylaldehyde Especially aMyl aldehyde Pivalaldehyde Trimethylacetaldehyde 2,2-Dimethylpropanal 2,2-Dimethylpropionaldehyde ANTI-LRIT1 (C-TERM) antibody produced in rabbit immunoglobulin-like domain and transmembrane domain-containing protein 1 Leucine-rich repeat LRIT1 LRRC21 Trimethylacetaldehyde solution, 75 wt. % in tert-butanol Pivalaldehyde (contains tert-Butanol) Pivaldehyde2,2-Dimethylpropanal Pivalic aldehyde 2,2-dimethylolpropanal Pivalaldehyde, Trimethylacetaldehyde Trimethylacetaldehyde, remainder 20% tert-butanol Trimethylacetaldehyde,ca75%intert-butanol Trimethylacetaldehyde,97% TRIMETHYL ACETALDEHYDE(PIVALDEHYDE) Pivaldehyde,97% Pivaldehyde, remainder 20% tert-butanol,ca 80% Trimethylacetaldehyde, 98+% Trimethylacetaldehyde,Pivalaldehyde, Trimethylacetaldehyde Pivaldehyde, AcroSeal, 97% Pivaldehyde, 97% 25GR Pivaldehyde, AcroSeal, 97% 100ML 2,2-DiMethylpropanone NSC 22043 2,2-Dimethylpropanal 2,2-Dimethylpropionaldehyde Trimethylacetaldehyde Pivaldehyde, Trimethylacetaldehyde Pivalaldehyde> Pivalyl Aldehyde Pivaldehyde, 96%, AcroSeal&trade PIVALDEHYDE Extra Pure Pivalaldehyde (7CI, 8CI) Pivaldehyde / 2,2-Dimethylpropanal 2,2-dimethyl-propana 2,2-DIMETHYLPROPANAL PAL PIVALALDEHYDE TRIMETHYLACETALDEHYDE