Vanillyl ethyl ether
- CAS No.
- 13184-86-6
- Chemical Name:
- Vanillyl ethyl ether
- Synonyms
- FEMA 3815;DAIRY ENHANCER;VanilinEthylEther;ETHYL VANILLYL ETHER;VANILLYL ETHYL ETHER;Vanilla alcohol ether;Xianglan alcohol ether;13184-86-6 Vanillyl ethyl ether;4-[ETHOXYMETHYL]-2-METHOXYPHENOL;Phenol, 4-(ethoxymethyl)-2-methoxy-
- CBNumber:
- CB2183240
- Molecular Formula:
- C10H14O3
- Molecular Weight:
- 182.22
- MDL Number:
- MFCD06409999
- MOL File:
- 13184-86-6.mol
- MSDS File:
- SDS
| Boiling point | 125°C/4mmHg(lit.) |
|---|---|
| Density | 1.087±0.06 g/cm3(Predicted) |
| refractive index | 1.5280 to 1.5320 |
| FEMA | 3815 | VANILLYL ETHYL ETHER |
| FLAVIS Number | 04.094 | Ethyl 4-hydroxy-3-methoxybenzyl ether |
| storage temp. | Inert atmosphere,Room Temperature |
| form | clear liquid |
| pka | 9.73±0.20(Predicted) |
| color | Colorless to Almost colorless |
| Odor | at 20.00 % in ethyl alcohol. alcoholic rum sweet chocolate creamy vanilla spicy nutmeg smoky |
| Odor Type | chocolate |
| JECFA Number | 887 |
| Henry's Law Constant | 4.1×102 mol/(m3Pa) at 25℃, McFall et al. (2020) |
| Major Application | flavors and fragrances |
| InChI | 1S/C10H14O3/c1-3-13-7-8-4-5-9(11)10(6-8)12-2/h4-6,11H,3,7H2,1-2H3 |
| InChIKey | KOCVACNWDMSLBM-UHFFFAOYSA-N |
| SMILES | OC1=C(OC)C=C(COCC)C=C1 |
| LogP | 1.46 |
| CAS DataBase Reference | 13184-86-6 |
| Substances Added to Food (formerly EAFUS) | VANILLYL ETHYL ETHER |
| EWG's Food Scores | 1 |
| FDA UNII | 1423UFT5P6 |
| NIST Chemistry Reference | Phenol, 4-(ethoxymethyl)-2-methoxy-(13184-86-6) |
| EPA Substance Registry System | Phenol, 4-(ethoxymethyl)-2-methoxy- (13184-86-6) |
| UNSPSC Code | 12164502 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2909500090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
Vanillyl ethyl ether price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1028 | 4-(Ethoxymethyl)-2-methoxyphenol >98.0%(GC) | 13184-86-6 | 5g | $98 | 2026-04-30 | Buy |
| Apolloscientific | OR950811 | 4-(Ethoxymethyl)-2-methoxyphenol >98% | 13184-86-6 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR950811 | 4-(Ethoxymethyl)-2-methoxyphenol >98% | 13184-86-6 | 25g | $54 | 2026-06-04 | Buy |
| Apolloscientific | OR950811 | 4-(Ethoxymethyl)-2-methoxyphenol >98% | 13184-86-6 | 100g | $172 | 2026-06-04 | Buy |
| Apolloscientific | OR950811 | 4-(Ethoxymethyl)-2-methoxyphenol >98% | 13184-86-6 | 500g | $840 | 2026-06-04 | Buy |
Vanillyl ethyl ether Chemical Properties, Uses, Production
Chemical Properties
Vanillyl ethyl ether has a phenolic, smoky odor and a strong, pungent taste.
Occurrence
Reportedly present in grape brandy (cognac), rum, whiskey and vanilla.
Uses
flavors and fragrances
Definition
ChEBI: 4-(Ethoxymethyl)-2-methoxyphenol is a member of phenols and a member of methoxybenzenes.
Preparation
In a patented process, prepared by the reaction of cyclodextrin or branched-cyclodextrin with vanillyl alcohol.
Synthesis
121-33-5
122-51-0
13184-86-6
General procedure for the synthesis of vanillyl ethyl ether from vanillin and triethyl orthoformate: 3.04 g (20.0 mmol) of vanillin, 5.93 g (40.0 mmol) of triethyl orthoformate, 15.0 mg of p-toluenesulphonic acid monohydrate, and 15.0 mg 5% palladium-carbon catalyst were added to a 100 ml autoclave (equipped with an inner tube). After displacing the internal gas of the system under nitrogen protection, it was replaced with hydrogen and filled with hydrogen at 3.0 MPa. The autoclave temperature was controlled at 130°C and the reaction was continuously stirred for 1 hour. Upon completion of the reaction, the reaction mixture was cooled and the hydrogen pressure was subsequently released. The palladium carbon catalyst was removed by filtration and the unreacted triethyl orthoformate was recovered by distillation under reduced pressure, resulting in 3.60 g of vanillyl ethyl ether (97.4% purity and 96.2% yield as determined by internal standard method). The structure of the product was confirmed by 1H-NMR (CDCl3): δ=1.37 (3H, t), 3.42 (1H, q), 3.86 (3H, s), 4.44 (2H, s), 5.92 (1H, s), 6.88 (3H, m).
References
[1] Patent: EP2813482, 2014, A1. Location in patent: Paragraph 0139; 0140
Vanillyl ethyl ether Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Ninxia Xindachang Technology Limited Company | 13832371507 | 515712684@qq.com | China | 36 | 58 |
| Jinan Ruitong Biotechnology Co., LTD | 1856-3757959 18563757959 | info@ritonbio.com | China | 72 | 58 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| jiliang chemicals | 21-62165282 | bidingchem@163.com | China | 1395 | 60 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 |
View Latest Price from Vanillyl ethyl ether manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | Vanillyl ethyl ether
13184-86-6
|
1kg | 98% | 1 | Jinan Ruitong Biotech Co., Ltd. | ||
 |
2025-05-23 | Vanillyl ethyl ether
13184-86-6
|
$50.00 | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2024-07-20 | Vanillyl ethyl ether
13184-86-6
|
1kg | 99% | 10ton | JINING XINHE CHEMICAL CO., LTD |
-
- Vanillyl ethyl ether
13184-86-6
- 98%
- Jinan Ruitong Biotech Co., Ltd.
-
- Vanillyl ethyl ether
13184-86-6
- $50.00
- 99
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- Vanillyl ethyl ether
13184-86-6
- 99%
- JINING XINHE CHEMICAL CO., LTD
