3-Chloro-2,4,5,6-tetrafluoropyridine

Uses

3-Chloro-2,4,5,6-Tetrafluoropyridine is an organic intermediate.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

3-Chloro-2,4,5,6-tetrafluoropyridine (3-chlorotetrafluoropyridine) is a fluoropyridine derivative. Its quantum mechanical calculations of energies, geometries and vibrational wave numbers have been performed by DFT level of theory. The interpretation of its FT-IR and FT-Raman spectra have been reported. It forms corresponding organo-zinc compound by reacting with zinc. 3-Chlorotetrafluoropyridine reacts with tris(diethylamino)phosphine (P(NEt)₃) in the presence of a proton donor to form product with fluorine replaced by hydrogen at position 4.

General Description

3-Chloro-2,4,5,6-tetrafluoropyridine (3-chlorotetrafluoropyridine) is a fluoropyridine derivative. Its quantum mechanical calculations of energies, geometries and vibrational wave numbers have been performed by DFT level of theory. The interpretation of its FT-IR and FT-Raman spectra have been reported. It forms corresponding organo-zinc compound by reacting with zinc. 3-Chlorotetrafluoropyridine reacts with tris(diethylamino)phosphine (P(NEt)₃) in the presence of a proton donor to form product with fluorine replaced by hydrogen at position 4.

Synthesis

3-Chloro-2,4,5,6-tetrafluoropyridine can be prepared from 3,5-dichloro-2,4,6-trifluoropyridine.

70g of 3,5-dichloro-2,4,6-trifluoropyridine, 22g of anhydrous potassium fluoride were mixed with 150mL of cyclobutanesulfone, and the reaction was stirred at 180C for 2.5h, lowered to room temperature, and samples were taken to monitor the complete conversion of the raw materials, and the reaction solution was decanted into 1L of ice water, and extracted with dichloromethane. The organic phase was washed with water and saturated sodium chloride solution in turn, dried with anhydrous sodium sulfate, concentrated under reduced pressure, the crude product obtained was purified by distillation to obtain 46.5g of colorless liquid, 3-chloro-2,4,5,6-tetrafluoropyridine, GC content of 98.3%, yield 72%.