4-Amino-2-fluorobenzoic acid
- CAS No.
- 446-31-1
- Chemical Name:
- 4-Amino-2-fluorobenzoic acid
- Synonyms
- BUTTPARK 22\09-96;4-AMINO-2-FLUOROBENZ;4-Carboxy-3-fluoroaniline;4-Amino-2-fluorobenzoic acid;2-FLUORO-4-AMINOBENZOIC ACID;4-azanyl-2-fluoro-benzoic acid;Benzoic acid, 4-amino-2-fluoro-;4-AMINO-2-FLUOROBENZENECARBOXYLIC ACID;4-AMINO-2-FLUOROBENZOIC ACID USP/EP/BP;4-Amino-2-Fluorobenzoic Acid 2-Fluoro-4-Aminobenzoic Acid
- CBNumber:
- CB2194129
- Molecular Formula:
- C7H6FNO2
- Molecular Weight:
- 155.13
- MDL Number:
- MFCD01569397
- MOL File:
- 446-31-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 210 °C (dec.) |
|---|---|
| Boiling point | 336.1±27.0 °C(Predicted) |
| Density | 1.430±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 3.93±0.10(Predicted) |
| color | White to Orange to Green |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C7H6FNO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,9H2,(H,10,11) |
| InChIKey | QHERSCUZBKDVOC-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(N)C=C1F |
| CAS DataBase Reference | 446-31-1(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2922498590 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Amino-2-fluorobenzoic acid price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 650625 | 4-Amino-2-fluorobenzoic acid 97% | 446-31-1 | 250mg | $73.7 | 2023-06-20 | Buy |
| Sigma-Aldrich | 650625 | 4-Amino-2-fluorobenzoic acid 97% | 446-31-1 | 1g | $108 | 2023-06-20 | Buy |
| TCI Chemical | A3164 | 4-Amino-2-fluorobenzoic Acid >98.0%(GC)(T) | 446-31-1 | 5g | $109 | 2026-04-30 | Buy |
| TCI Chemical | A3164 | 4-Amino-2-fluorobenzoic Acid >98.0%(GC)(T) | 446-31-1 | 25g | $434 | 2026-04-30 | Buy |
| Usbiological | 232760 | 4-Amino-2-fluorobenzoic acid 99+% ≥99%(Assay) | 446-31-1 | 1g | $163 | 2026-06-03 | Buy |
4-Amino-2-fluorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
mp 216- 216.5°C
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
403-24-7
446-31-1
2-Fluoro-4-nitrobenzoic acid (1.0 g, 5.4 mmol) was used as a raw material and dissolved in 20 mL of a solvent mixture of acetic acid and methanol (1:1, v/v). A catalytic amount of palladium carbon (25 mg) was added and the reaction was stirred overnight at room temperature under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. Subsequently, the solvent was removed by distillation under reduced pressure to afford 4-amino-2-fluorobenzoic acid (0.86 g, 100% yield) as a cream colored solid.
References
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 27, p. 6730 - 6739
[2] Patent: WO2004/11460, 2004, A2. Location in patent: Page 57
[3] Patent: WO2010/132615, 2010, A1. Location in patent: Page/Page column 133
[4] Journal of the American Chemical Society, 1944, vol. 66, p. 1631
[5] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2697 - 2706
4-Amino-2-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Ruide Famo Technology Co., Ltd | 13821803402 | RD_PHARM@163.com | China | 842 | 58 |
| Changzhou Jiezhan Chemical Technology Co., Ltd | 15861130028 | 956912955@qq.com | China | 300 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Lastest Price from 4-Amino-2-fluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-AMINO-2-FLUOROBENZOIC ACID
446-31-1
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2020-01-01 | 4-AMINO-2-FLUOROBENZOIC ACID
446-31-1
|
$1.00 | 1KG | 99% | 10000KGS | Career Henan Chemical Co |
-
- 4-AMINO-2-FLUOROBENZOIC ACID
446-31-1
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-AMINO-2-FLUOROBENZOIC ACID
446-31-1
- $1.00
- 99%
- Career Henan Chemical Co
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