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4-AMINO-2-FLUOROBENZOIC ACID

4-AMINO-2-FLUOROBENZOIC ACID structure

CAS No.: 446-31-1

Chemical Name:: 4-AMINO-2-FLUOROBENZOIC ACID

Synonyms: BUTTPARK 22\09-96;4-AMINO-2-FLUOROBENZ;4-Carboxy-3-fluoroaniline;2-FLUORO-4-AMINOBENZOIC ACID;4-AMINO-2-FLUOROBENZOIC ACID;4-azanyl-2-fluoro-benzoic acid;Benzoic acid, 4-amino-2-fluoro-;4-AMINO-2-FLUOROBENZENECARBOXYLIC ACID;4-AMINO-2-FLUOROBENZOIC ACID USP/EP/BP;4-Amino-2-Fluorobenzoic Acid 2-Fluoro-4-Aminobenzoic Acid

CBNumber:: CB2194129

Molecular Formula:: C7H6FNO2

Molecular Weight:: 155.13

MDL Number:: MFCD01569397

MOL File:: 446-31-1.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
4-Amino-2-fluorobenzoic acid 97%	650625	250mg	$73.7
4-Amino-2-fluorobenzoic acid 97%	650625	1g	$108
4-Amino-2-fluorobenzoic Acid >98.0%(GC)(T)	A3164	5g	$92
4-Amino-2-fluorobenzoic Acid >98.0%(GC)(T)	A3164	25g	$365
4-Amino-2-fluorobenzoic Acid	A634698	2.5g	$75
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4-AMINO-2-FLUOROBENZOIC ACID Properties

Melting point	210 °C (dec.)
Boiling point	336.1±27.0 °C(Predicted)
Density	1.430±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	powder to crystal
pka	3.93±0.10(Predicted)
color	White to Orange to Green
InChI	InChI=1S/C7H6FNO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,9H2,(H,10,11)
InChIKey	QHERSCUZBKDVOC-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC=C(N)C=C1F
CAS DataBase Reference	446-31-1(CAS DataBase Reference)
UNSPSC Code	12352106
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

Xn,Xi

Risk Statements

22-37/38-41

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

2922498590

NFPA 704

	0
2		0

4-AMINO-2-FLUOROBENZOIC ACID price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	650625	4-Amino-2-fluorobenzoic acid 97%	446-31-1	250mg	$73.7	2023-06-20	Buy
Sigma-Aldrich	650625	4-Amino-2-fluorobenzoic acid 97%	446-31-1	1g	$108	2023-06-20	Buy
TCI Chemical	A3164	4-Amino-2-fluorobenzoic Acid >98.0%(GC)(T)	446-31-1	5g	$92	2025-07-31	Buy
TCI Chemical	A3164	4-Amino-2-fluorobenzoic Acid >98.0%(GC)(T)	446-31-1	25g	$365	2025-07-31	Buy
TRC	A634698	4-Amino-2-fluorobenzoic Acid	446-31-1	2.5g	$75	2021-12-16	Buy

Product number	Packaging	Price	Buy
650625	250mg	$73.7	Buy
650625	1g	$108	Buy
A3164	5g	$92	Buy
A3164	25g	$365	Buy
A634698	2.5g	$75	Buy

4-AMINO-2-FLUOROBENZOIC ACID Chemical Properties,Uses,Production

Chemical Properties

mp 216- 216.5°C

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

403-24-7

446-31-1

2-Fluoro-4-nitrobenzoic acid (1.0 g, 5.4 mmol) was used as a raw material and dissolved in 20 mL of a solvent mixture of acetic acid and methanol (1:1, v/v). A catalytic amount of palladium carbon (25 mg) was added and the reaction was stirred overnight at room temperature under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. Subsequently, the solvent was removed by distillation under reduced pressure to afford 4-amino-2-fluorobenzoic acid (0.86 g, 100% yield) as a cream colored solid.

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 27, p. 6730 - 6739
[2] Patent: WO2004/11460, 2004, A2. Location in patent: Page 57
[3] Patent: WO2010/132615, 2010, A1. Location in patent: Page/Page column 133
[4] Journal of the American Chemical Society, 1944, vol. 66, p. 1631
[5] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2697 - 2706

4-AMINO-2-FLUOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

2-Fluoro-4-nitrobenzoic acid Methanol Hydrogen Acetic acid

Preparation Products

methyl 4-amino-2-fluorobenzoate hydrochloride 4-[(1-Carboxy-1-methylethyl)amino]-2-fluorobenzoic acid

4-AMINO-2-FLUOROBENZOIC ACID Suppliers

Global( 293)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2953	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2176	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58
Changzhou Ditong Chemical Co.,Ltd	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 4-AMINO-2-FLUOROBENZOIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-17	4-AMINO-2-FLUOROBENZOIC ACID 446-31-1	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-08-08	4-Amino-2-fluorobenzoic acid 446-31-1	US $100.00 / kg	1kg	99%	50000KG/month	Sichuan Zhuoyu Yantang Technology Co., Ltd.
2020-01-01	4-AMINO-2-FLUOROBENZOIC ACID 446-31-1	US $1.00 / KG	1KG	99%	10000KGS	Career Henan Chemical Co

4-AMINO-2-FLUOROBENZOIC ACID
446-31-1
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Amino-2-fluorobenzoic acid
446-31-1
US $100.00 / kg
99%
Sichuan Zhuoyu Yantang Technology Co., Ltd.

4-AMINO-2-FLUOROBENZOIC ACID
446-31-1
US $1.00 / KG
99%
Career Henan Chemical Co

4-AMINO-2-FLUOROBENZOIC ACID Spectrum

4-AMINO-2-FLUOROBENZOIC ACID(446-31-1)¹HNMR

446-31-1(4-AMINO-2-FLUOROBENZOIC ACID)Related Search:

2-Fluoro-4-nitrobenzoic acid 2-Fluorobenzoic acid 4-Bromo-2-fluoro-N-methylbenzamide 4-BROMO-2-FLUOROBENZAMIDE 4-amino-2-fluoro-N-methylbenzamide

4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- Enzalutamide Impurity 7 Benzoic acid, 4-isothiocyanato-2-(trifluoromethyl)- 2-FLUORO-N-METHYL-4-NITROBENZAMIDE 4-Amino-2-(trifluoromethyl)benzamide

4-NITRO-2-(TRIFLUOROMETHYL)BENZONITRILE 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 1 Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-5,5-dimethyl-4-oxo-1-imidazolidinyl]-2-fluoro-N-methyl- Benzamide, 4-amino-2-fluoro- (9CI)

4-Amino-2-fluoro-N,N-dimethylbenzamide 4-AMINO-2-TRIFLUOROMETHYLBENZOIC ACID METHYL 2-FLUORO-4-NITROBENZENECARBOXYLATE

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2-FLUORO-4-AMINOBENZOIC ACID BUTTPARK 22\09-96 4-AMINO-2-FLUOROBENZENECARBOXYLIC ACID 4-AMINO-2-FLUOROBENZOIC ACID 4-azanyl-2-fluoro-benzoic acid 4-AMINO-2-FLUOROBENZ 4-Carboxy-3-fluoroaniline Benzoic acid, 4-amino-2-fluoro- 4-Amino-2-Fluorobenzoic Acid 2-Fluoro-4-Aminobenzoic Acid 4-AMINO-2-FLUOROBENZOIC ACID USP/EP/BP 446-31-1 Aromatic Amino Acids Specialty Synthesis Unnatural Amino Acid Derivatives Peptide Synthesis Fluorine series Fluorin-contained Benzoic acid series Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Aromatic Amino Acids Peptide Synthesis Unnatural Amino Acid Derivatives intermediate