1-Naphthylamine-4,6,8-trisulfonic acid
- CAS No.
- 17894-99-4
- Chemical Name:
- 1-Naphthylamine-4,6,8-trisulfonic acid
- Synonyms
- 1-NAPHTHYLAMINE-4,6,8-TRISULFONIC ACID;8-aminonaphthalene-1,3,5-trisulfonicaci;8-AMINO-1,3,5-NAPHTHALENETRISULFONIC ACID;8-azanylnaphthalene-1,3,5-trisulfonic acid;8-aminonaphthalene-1,3,5-trisulphonic acid;8-AMINO-NAPHTHALENE-1,3,5-TRISULFONIC ACID;1,3,5-Naphthalenetrisulfonic acid, 8-amino-
- CBNumber:
- CB2201236
- Molecular Formula:
- C10H9NO9S3
- Molecular Weight:
- 383.37
- MDL Number:
- MFCD00035848
- MOL File:
- 17894-99-4.mol
- MSDS File:
- SDS
| Density | 1.974±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| pka | -1.75±0.40(Predicted) |
| InChI | InChI=1S/C10H9NO9S3/c11-7-1-2-8(22(15,16)17)6-3-5(21(12,13)14)4-9(10(6)7)23(18,19)20/h1-4H,11H2,(H,12,13,14)(H,15,16,17)(H,18,19,20) |
| InChIKey | RQVVDWMOCSOAJS-UHFFFAOYSA-N |
| SMILES | C1(S(O)(=O)=O)=C2C(C(S(O)(=O)=O)=CC=C2N)=CC(S(O)(=O)=O)=C1 |
1-Naphthylamine-4,6,8-trisulfonic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA0026G3 | 8-Aminonaphthalene-1,3,5-trisulfonic acid 95+% | 17894-99-4 | 1g | $1925 | 2026-05-28 | Buy |
| Crysdot | CD12131218 | 8-Aminonaphthalene-1,3,5-trisulfonic acid 95+% | 17894-99-4 | 5g | $823 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | CHM0006894 | 1-NAPHTHYLAMINE-4,6,8-TRISULFONIC ACID 95.00% | 17894-99-4 | 5G | $1127.86 | 2021-12-16 | Buy |
| Alichem | 17894994 | 8-Aminonaphthalene-1,3,5-trisulfonicacid | 17894-99-4 | 1g | $1246 | 2021-12-16 | Buy |
| Alichem | 17894994 | 8-Aminonaphthalene-1,3,5-trisulfonicacid | 17894-99-4 | 5g | $1917 | 2021-12-16 | Buy |
1-Naphthylamine-4,6,8-trisulfonic acid Chemical Properties, Uses, Production
Chemical Properties
1-Aminonaphthalene-4,6,8-trisulfonic acid [17894-99-4]. (8-aminonaphthalene1,3,5-trisulfonic acid), B acid, C10H9NO9S3, Mr 383.36, is reduced with zinc and alkali to 1- aminonaphthalene-4,6-disulfonic acid. Heating with aqueous sulfuric acid causes desulfonation to form 1-aminonaphthalene-6,8-disulfonic acid. Sulfonation (25 % oleum, 90℃) gives the sultam of 1-aminonaphthalene-2,4,6,8-tetrasulfonic acid.
Uses
Alkali fusion of B acid yields K acid. A special outlet for purified B acid is in the synthesis of the drug suramin sodium (Bayer 205) . 1-Aminonaphthalene-4,6,8-trisulfonic acid is acylated with 2-nitrotoluyl chloride, and this product is reduced and acylated with mnitrobenzoyl chloride. This intermediate is reduced and finally phosgenated to give suramin sodium, which has been used to treat trypanosomiasis and onchocerciasis.
Production Methods
Naphthalene is sulfonated under conditions that maximize formation of the 1,3,5-trisulfonic acid, followed by nitration with H2SO4– HNO3 in situ at 35℃. After quenching, neutralization with calcium carbonate, and reduction of the nitro-derivative with iron under acid conditions, the byproduct 1- aminonaphthalene-3,6,8-trisulfonic acid (18 % yield) is selectively precipitated by acidification. The desired isomer is then precipitated by further acidification and salting of the filtrates, and finally purified by reprecipitation. Overall yield is 25 – 30 %.
1-Naphthylamine-4,6,8-trisulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Suzhou Hengning Pharmaceutical Technology Co., Ltd. | 0512-65649061 17365378613; | hengningpharma@163.com | China | 150 | 58 |
| Jinan Guoding Pharmaceutical Technology Co., Ltd. | 053167801621 15665775653 | sales@guodingpharma.com | China | 479 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Wuhan Ruilida Biomedical Technology Co., Ltd. | 18201884268 | magean83@163.com | China | 2510 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
View Latest Price from 1-Naphthylamine-4,6,8-trisulfonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 1-Naphthylamine-4,6,8-trisulfonic acid
17894-99-4
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
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- 1-Naphthylamine-4,6,8-trisulfonic acid
17894-99-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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