SENEGENIN
- CAS No.
- 2469-34-3
- Chemical Name:
- SENEGENIN
- Synonyms
- SENEGIN;Tenuigenin;SENEGENIN;Tenuifgenin;Senegenin-RM;Tenuifolic acid;Senegenin (6CI);Senegenin, >=98%;Tenuigenin (Standard);Tenuigenin (Senegenin)
- CBNumber:
- CB2222527
- Molecular Formula:
- C30H45ClO6
- Molecular Weight:
- 537.13
- MDL Number:
- MFCD00466906
- MOL File:
- 2469-34-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Senegenin ≥98% (HPLC) | SML1001 | 5mg | $76.4 |
| Senegenin ≥98% (HPLC) | SML1001 | 25mg | $464 |
| Tenuigenin ≥98% | 28824 | 5mg | $61 |
| Tenuigenin ≥98% | 28824 | 10mg | $109 |
| Tenuigenin ≥98% | 28824 | 25mg | $258 |
| More product size | |||
| Melting point | 290-292℃ |
|---|---|
| alpha | D +19° (c = 0.70 in ethanol) |
| Boiling point | 674.1±55.0 °C(Predicted) |
| Density | 1.28 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 4.27±0.70(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | CWHJIJJSDGEHNS-JEKQWPLRNA-N |
| SMILES | C[C@]12C[C@H](O)[C@H](O)[C@@](C)(C(=O)O)[C@]1([H])CC[C@]1(C3CC[C@]4(CCC(C)(C)C[C@@]4([H])C=3[C@@H](CCl)C[C@]21[H])C(=O)O)C |&1:1,3,5,7,12,16,20,27,30,34,r| |
| FDA UNII | 06S1QH951L |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC8815000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 3mg/kg | |||||||||
| NFPA 704 |
|
SENEGENIN price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1001 | Senegenin ≥98% (HPLC) | 2469-34-3 | 5mg | $76.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1001 | Senegenin ≥98% (HPLC) | 2469-34-3 | 25mg | $464 | 2023-06-20 | Buy |
| Cayman Chemical | 28824 | Tenuigenin ≥98% | 2469-34-3 | 5mg | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 28824 | Tenuigenin ≥98% | 2469-34-3 | 10mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 28824 | Tenuigenin ≥98% | 2469-34-3 | 25mg | $258 | 2026-04-30 | Buy |
SENEGENIN Chemical Properties,Uses,Production
Description
Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Polygala tenuifolia.
Uses
Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.
Definition
ChEBI: Senegenin is a 12alpha-hydroxy steroid.
in vivo
Tenuigenin (2, 4, 8 mg/kg) significantly attenuates S.aureus-induced lung histopathological changes. Tenuigenin also inhibits lung wet/dry (W/D) ratio, and inflammatory cytokines TNF-α and IL-1β production in Male BALB/c mice[1].
IC 50
NF-κB
References
[1] J. J. DUGAN A S P Mayo. TERPENOIDS: V. SENEGENIN: FUNCTIONAL GROUPS AND PART STRUCTURE[J]. Canadian Journal of Chemistry, 1964, 143 1: 491-501. DOI: 10.1139/v64-073
[2] ZHENG FAN. Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia.[J]. Journal of Neuroinflammation, 2017: 256. DOI: 10.1186/s12974-017-1036-x
[3] BIN YU . Protective effects of tenuigenin on Staphylococcus aureus-induced pneumonia in mice[J]. Microbial pathogenesis, 2017, 110: Pages 385-389. DOI: 10.1016/j.micpath.2017.07.023
SENEGENIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 4616 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
View Lastest Price from SENEGENIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | SENEGENIN
2469-34-3
|
1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
 |
2023-02-24 | Senegenin
2469-34-3
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2023-02-24 | Senegenin
2469-34-3
|
5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |
