Senegenin
- CAS No.
- 2469-34-3
- Chemical Name:
- Senegenin
- Synonyms
- SENEGIN;Tenuigenin;Senegenin;Tenuifgenin;Senegenin-RM;Tenuifolic acid;Senegenin (6CI);Senegenin, >=98%;Tenuigenin (Standard);Tenuigenin (Senegenin)
- CBNumber:
- CB2222527
- Molecular Formula:
- C30H45ClO6
- Molecular Weight:
- 537.13
- MDL Number:
- MFCD00466906
- MOL File:
- 2469-34-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 290-292℃ |
|---|---|
| alpha | D +19° (c = 0.70 in ethanol) |
| Boiling point | 674.1±55.0 °C(Predicted) |
| Density | 1.28 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 4.27±0.70(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | CWHJIJJSDGEHNS-JEKQWPLRNA-N |
| SMILES | C[C@]12C[C@H](O)[C@H](O)[C@@](C)(C(=O)O)[C@]1([H])CC[C@]1(C3CC[C@]4(CCC(C)(C)C[C@@]4([H])C=3[C@@H](CCl)C[C@]21[H])C(=O)O)C |&1:1,3,5,7,12,16,20,27,30,34,r| |
| FDA UNII | 06S1QH951L |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC8815000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 3mg/kg | |||||||||
| NFPA 704 |
|
Senegenin price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1001 | Senegenin ≥98% (HPLC) | 2469-34-3 | 5mg | $76.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1001 | Senegenin ≥98% (HPLC) | 2469-34-3 | 25mg | $464 | 2023-06-20 | Buy |
| Cayman Chemical | 28824 | Tenuigenin ≥98% | 2469-34-3 | 5mg | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 28824 | Tenuigenin ≥98% | 2469-34-3 | 10mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 28824 | Tenuigenin ≥98% | 2469-34-3 | 25mg | $258 | 2026-04-30 | Buy |
Senegenin Chemical Properties, Uses, Production
Description
Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Polygala tenuifolia.
Uses
Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.
Definition
ChEBI: Senegenin is a 12alpha-hydroxy steroid.
in vivo
Tenuigenin (2, 4, 8 mg/kg) significantly attenuates S.aureus-induced lung histopathological changes. Tenuigenin also inhibits lung wet/dry (W/D) ratio, and inflammatory cytokines TNF-α and IL-1β production in Male BALB/c mice[1].
IC 50
NF-κB
References
[1] J. J. DUGAN A S P Mayo. TERPENOIDS: V. SENEGENIN: FUNCTIONAL GROUPS AND PART STRUCTURE[J]. Canadian Journal of Chemistry, 1964, 143 1: 491-501. DOI: 10.1139/v64-073
[2] ZHENG FAN. Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia.[J]. Journal of Neuroinflammation, 2017: 256. DOI: 10.1186/s12974-017-1036-x
[3] BIN YU . Protective effects of tenuigenin on Staphylococcus aureus-induced pneumonia in mice[J]. Microbial pathogenesis, 2017, 110: Pages 385-389. DOI: 10.1016/j.micpath.2017.07.023
Senegenin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Aktin Chemicals, Inc. | 86-28-85159085 | info@aktinchem.com | China | 297 | 62 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Chengdu Climax Biotech Co., Ltd. | 028-83311324 1278112614 | climaxbiotech@gmail.com | China | 925 | 58 |
| Shanghai Winherb Medical Technology Co., Ltd. | 17301719108 13341702378 | winherb@126.com | China | 1245 | 58 |
View Latest Price from Senegenin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-04-12 | SENEGENIN
2469-34-3
|
1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
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2023-02-24 | Senegenin
2469-34-3
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
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2023-02-24 | Senegenin
2469-34-3
|
5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |
