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2-Chloro-N-pyridin-2-yl-acetamide

2-Chloro-N-pyridin-2-yl-acetamide Structure
2-Chloro-N-pyridin-2-yl-acetamide structure
CAS No.
5221-37-4
Chemical Name:
2-Chloro-N-pyridin-2-yl-acetamide
Synonyms
AKOS B015665;AKOS BBS-00004069;ART-CHEM-BB B015665;TIMTEC-BB SBB000164;2-(Chloroacetylamino)pyridine;N-(PYRID-2-YL)-CHLOROACETAMIDE;2-chloro-N-(2-pyridyl)acetamide;2-Chloro-N-pyridin-2-yl-acetamide;Acetamide, 2-chloro-N-2-pyridinyl-;2-chloro-N-pyridin-2-yl-ethanamide
CBNumber:
CB2224031
Molecular Formula:
C7H7ClN2O
Molecular Weight:
170.6
MDL Number:
MFCD00023426
MOL File:
5221-37-4.mol
MSDS File:
SDS
Last updated:2026-09-12 18:50:27
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2-Chloro-N-pyridin-2-yl-acetamide Properties

Melting point 110 °C
Boiling point 378.1±22.0 °C(Predicted)
Density 1.341±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 11.59±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2933399990

2-Chloro-N-pyridin-2-yl-acetamide price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR939010 2-Chloro-N-pyridin-2-ylacetamide 95% 5221-37-4 1g $245 2026-06-04 Buy
Apolloscientific OR939010 2-Chloro-N-pyridin-2-ylacetamide 95% 5221-37-4 5g $742 2026-06-04 Buy
Activate Scientific AS26491 2-Chloro-N-(2-pyridyl)acetamide 95% 5221-37-4 1g $284 2026-06-04 Buy
Activate Scientific AS26491 2-Chloro-N-(2-pyridyl)acetamide 95% 5221-37-4 5g $788 2026-06-04 Buy
aablocks AA00D8I5 2-Chloro-N-pyridin-2-ylacetamide 96% 5221-37-4 250mg $107 2026-05-28 Buy
Product number Packaging Price Buy
OR939010 1g $245 Buy
OR939010 5g $742 Buy
AS26491 1g $284 Buy
AS26491 5g $788 Buy
AA00D8I5 250mg $107 Buy

2-Chloro-N-pyridin-2-yl-acetamide Chemical Properties, Uses, Production

Synthesis

2-Aminopyridine

504-29-0

Chloroacetyl chloride

79-04-9

2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE

5221-37-4

1. Dissolve 2-aminopyridine (2.8 g, 30 mmol) in 50 mL of ethylene dichloride (25 mL) in a 50 mL glass container. 2. Slowly add chloroacetyl chloride dropwise to the above solution. 3. seal the glass vessel with a TFM Teflon lid and place it in the rotor of the microwave reactor. 4. Microwave irradiate the mixture for 5 minutes at 300 W power and 80 °C. 5. 5. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 9 with saturated aqueous sodium hydroxide solution. 6. The reaction mixture was extracted twice with dichloroethane. 7. The organic layers were combined and dried with anhydrous sodium sulfate. 8. The solvent was removed by rotary evaporator to give the crude product. 9. The crude product was recrystallized using acetonitrile to give 4.9 g (97% yield) of 2-chloro-N-pyridin-2-ylacetamide as a pink solid. 10. The melting point of the product is 110-115 °C. 11. The product was analyzed by IR (Kjeldahl). 11. The product was analyzed by IR (KBr) and showed characteristic absorption peaks at 3443, 3226, 1683, 1581, 1330, 1198, 775 cm-1. 12. 1H NMR (KBr) analysis showed the product to be in the range of 1H NMR (1H NMR, 1H NMR). 12. 1H NMR (CDCl3) data: δ 4.2 (2H, s), 7.1 (1H, d), 7.7 (1H, t), 8.2 (1H, d, J = 8.3 Hz), 8.4 (1H, d, J = 4.9 Hz), 8.95 (1H, bs). 13. 13C NMR (CDCl3) data: δ 43.2, 111.4, 121.0, 139.1, 148.2, 150.7, 164.9. 14. EIMS analysis showed a molecular ion peak m/z of 170.6 (M+).

References

[1] Patent: US2007/36715, 2007, A1. Location in patent: Page/Page column 4-5
[2] Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, vol. 31, p. 96 - 103
[3] Organic Letters, 2016, vol. 18, # 20, p. 5440 - 5443
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2060 - 2068
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 6, p. 2003 - 2010

2-Chloro-N-pyridin-2-yl-acetamide synthesis

504-29-0
79-04-9
5221-37-4
Synthesis of 2-Chloro-N-pyridin-2-yl-acetamide from 2-Aminopyridine and Chloroacetyl chloride

2-Chloro-N-pyridin-2-yl-acetamide Preparation Products And Raw materials

Raw materials

2-Aminopyridine Chloroacetyl chloride Chloroacetic acid 1,2-Dichloroethane

Preparation Products

Cyclohexanecarboxamide, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-, hydrochloride (1:3)

2-Chloro-N-pyridin-2-yl-acetamide Suppliers

Global Suppliers ( 72)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9656 58
Nanjing Chalf-Pharm Technology Co., Ltd. 025-57018978 18251899859 sales@chalf-pharm.com China 5855 50
Shanghai Tombiopharma Chemical Co. Ltd. 13391076197 tombiopharma@163.com China 4986 55
Wuhan Chemwish Technology Co.， Ltd 027-67849912 sales@chemwish.com China 9144 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Dalian lichuang Chemical Co., Ltd 0411-0411-00000000 13644282108 3500508746@qq.com China 2942 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sphchem Co., Ltd. 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Clearsynth Labs Limited 58
Nanjing Chalf-Pharm Technology Co., Ltd. 50
Shanghai Tombiopharma Chemical Co. Ltd. 55
Wuhan Chemwish Technology Co.， Ltd 60
Amadis Chemical Company Limited 58
Dalian lichuang Chemical Co., Ltd 55

View Latest Price from 2-Chloro-N-pyridin-2-yl-acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE pictures 2020-01-09 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE
5221-37-4
 $1.00 1KG 99% 200kg Career Henan Chemical Co

5221-37-4 (2-Chloro-N-pyridin-2-yl-acetamide) Related Search:

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N-(PYRID-2-YL)-CHLOROACETAMIDE TIMTEC-BB SBB000164 2-chloro-N-(2-pyridyl)acetamide 2-chloro-N-pyridin-2-yl-ethanamide AKOS B015665 AKOS BBS-00004069 ART-CHEM-BB B015665 Acetamide, 2-chloro-N-2-pyridinyl- 2-(Chloroacetylamino)pyridine 2-Chloro-N-pyridin-2-yl-acetamide 5221-37-4