Ethyl 6-chloronicotinate
- CAS No.
- 49608-01-7
- Chemical Name:
- Ethyl 6-chloronicotinate
- Synonyms
- Ethyl 6-chloropyridine-3-carboxylate;6-chloro ethyl sMoke;Ethyl 6-chloronicoti;6-Chloronictinic Acid;Ethyl 6-chloronicotite;thyl 6-chloronicotinate;ETHYL 6-CHLORONICOTINATE;Ethyl6-Chloronicotinate>Ethyl6-chloronicotinate,97%;Ethyl 6-Chloro-3-nicotinate
- CBNumber:
- CB2236371
- Molecular Formula:
- C8H8ClNO2
- Molecular Weight:
- 185.61
- MDL Number:
- MFCD00082739
- MOL File:
- 49608-01-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 26-30 °C(lit.) |
|---|---|
| Boiling point | 98 °C |
| Density | 1.245±0.06 g/cm3(Predicted) |
| refractive index | 1.522 |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -1.95±0.10(Predicted) |
| color | Colourless to Off-White Oil |
| BRN | 4742175 |
| InChI | 1S/C8H8ClNO2/c1-2-12-8(11)6-3-4-7(9)10-5-6/h3-5H,2H2,1H3 |
| InChIKey | ILDJJTQWIZLGPO-UHFFFAOYSA-N |
| SMILES | CCOC(=O)c1ccc(Cl)nc1 |
| CAS DataBase Reference | 49608-01-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
Ethyl 6-chloronicotinate price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 531197 | Ethyl 6-chloropyridine-3-carboxylate 97% | 49608-01-7 | 25g | $45.6 | 2026-04-30 | Buy |
| TCI Chemical | E0852 | Ethyl 6-Chloronicotinate >97.0%(GC) | 49608-01-7 | 5g | $57 | 2026-04-30 | Buy |
| TCI Chemical | E0852 | Ethyl 6-Chloronicotinate >97.0%(GC) | 49608-01-7 | 25g | $181 | 2026-04-30 | Buy |
| TRC | TRC-C373680-50G | 6-Chloronicotinic Acid Ethyl Ester | 49608-01-7 | 50g | $302 | 2026-06-03 | Buy |
| TRC | TRC-C373680-25G | 6-Chloronicotinic Acid Ethyl Ester | 49608-01-7 | 25g | $176 | 2026-06-03 | Buy |
Ethyl 6-chloronicotinate Chemical Properties, Uses, Production
Synthesis
50 g (0.317 mol) of 6-chloronicotinic acid, 500 ml of acetonitrile, and 56.6 g (0.35 mol) of carbonyl diimidazole were stirred at room temperature for 2 h. Then, 52 ml (0.8 mol) of ethanol was added to the solution, and stirring continued for 2 h. The reaction progress was monitored by TLC. After the reaction was complete, the solvent was removed under vacuum. The residue was dissolved in 1 L of dichloromethane. The resulting dichloromethane layer was washed with water and then with a saturated sodium bicarbonate aqueous solution. The organic layer was dried over anhydrous sodium sulfate, and the sodium sulfate solid was removed by filtration. The filtrate was concentrated under reduced pressure to obtain the target compound.
Chemical Properties
White to light yellow solid or colorless to yellow liquid
Uses
Ethyl 6-chloronicotinate is a nicotinic acid derivative used in the preparation of potent H3 receptor antagonists.
Uses
Ethyl 6-chloropyridine-3-carboxylate (Ethyl 6-chloronicotinate) may be used in the preparation of ethyl 5-{[5-(1H-benzimidazol-2-yl)pyridin-2-yl]ethynyl}pyridine-2-carboxylate by reacting with 2-[6-(ethynyl)pyridin-3-yl]-1H-benzimidazole under microwave irradiation.
General Description
Ethyl 6-chloropyridine-3-carboxylate (Ethyl-6-chloronicotinate, E-6-ClN) undergoes direct amidation on reacting with benzylamine in the presence lanthanum trifluoromethanesulfonate La(OTf)3. The structural and physicochemical properties of E-6-ClN have been investigated based on its spectroscopic data, time-dependent density functional theory and density of state diagrams.
Ethyl 6-chloronicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from Ethyl 6-chloronicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Ethyl 6-chloronicotinate
49608-01-7
|
$1.00 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-04 | Ethyl 6-chloronicotinate
49608-01-7
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | Ethyl 6-chloronicotinate
49608-01-7
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Ethyl 6-chloronicotinate
49608-01-7
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethyl 6-chloronicotinate
49608-01-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Ethyl 6-chloronicotinate
49608-01-7
- $1.00
- 99%
- Career Henan Chemical Co
