H-D-ALLO-THR-OME HCL
- CAS No.
- 60538-18-3
- Chemical Name:
- H-D-ALLO-THR-OME HCL
- Synonyms
- H-D-allo-Thr-OMe;H-D-ALLO-THR-OME HCL;hydrochloride - [M87065];H-D-Allo-Thr-Ome Hydrochloride;D(-)-allo-Threonine Methyl ester HCl;Methyl D-allo-threoninate hydrochloride;methyl (2R,3R)-2-amino-3-hydroxybutanoate;H-D-allo-Threonine Methyl Ester Hydrochloride;D(-)-allo-Threonine methyl ester hydrochloride;D-allothreonine methyl ester hydrochloride salt
- CBNumber:
- CB2237853
- Molecular Formula:
- C5H12ClNO3
- Molecular Weight:
- 169.61
- MDL Number:
- MFCD08458597
- MOL File:
- 60538-18-3.mol
| Product description | Number | Pack Size | Price |
| H-D-allo-Threonine methyl ester hydrochloride | 260808 | 250mg | $350 |
| H-D-allo-ThreonineMethylEsterHydrochloride | A548560 | 5g | $825 |
| H-D-allo-Threoninemethylesterhydrochloride | X4361 | 10g | $885 |
| H-D-ALLO-THR-OME HYDROCHLORIDE 95.00% | AAA0010092 | 1G | $896 |
| H-D-allo-Thr-OMe?·HCl | 37616 | 1g | $410 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P302+P352-P304+P340-P305+P351+P338 |
H-D-ALLO-THR-OME HCL price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 260808 | H-D-allo-Threonine methyl ester hydrochloride | 60538-18-3 | 250mg | $350 | 2021-12-16 | Buy |
| TRC | A548560 | H-D-allo-ThreonineMethylEsterHydrochloride | 60538-18-3 | 5g | $825 | 2021-12-16 | Buy |
| AK Scientific | X4361 | H-D-allo-Threoninemethylesterhydrochloride | 60538-18-3 | 10g | $885 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0010092 | H-D-ALLO-THR-OME HYDROCHLORIDE 95.00% | 60538-18-3 | 1G | $896 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 37616 | H-D-allo-Thr-OMe?·HCl | 60538-18-3 | 1g | $410 | 2021-12-16 | Buy |
H-D-ALLO-THR-OME HCL Chemical Properties,Uses,Production
Uses
H-D-allo-Threonine Methyl Ester Hydrochloride is used to prepare inhibitors of hepatitis A virus 3C cysteine proteinase.
Synthesis
67-56-1
28954-12-3
39994-75-7
General procedure for the synthesis of L-threonine methyl ester hydrochloride from methanol and (2S,3S)-2-amino-3-hydroxybutanoic acid: a mixture of (2S,3S)-2-amino-3-hydroxybutanoic acid (5.4 g, 24.6 mmol) and 6N HCl (60 mL) was refluxed for 5 hours. After completion of the reaction, it was cooled to room temperature and extracted with ether (3 x 70 mL) to remove the by-product benzoic acid. The aqueous phase was concentrated to dryness under reduced pressure and the residue was dried overnight under high vacuum to give crude allo-L-threonine. Methanol (25 mL) was cooled to 0 °C and thionyl chloride (1.80 mL, 25.2 mmol) was added slowly and dropwise. Crude allo-L-threonine was added to the above prepared HCl methanol solution and the reaction mixture was heated to reflux for 1 hour. After removing the solvent under reduced pressure, another batch of HCl methanol solution prepared by the same method was added and heated and refluxed again for 1 hour. The solvent was finally removed under reduced pressure to give allo-L-threonine methyl ester hydrochloride (4.15 g, 98% overall yield in two steps) as a red solid. The product was identified by 1H NMR (300 MHz, CD3OD): δ1.27 (d, J=6.6 Hz, 3H), 4.03 (d, J=3.3 Hz, 1H), 4.27-4.33 (m, 1H); 13C NMR (75 MHz, CD3OD): δ17.13,58.17,65.11,167.62; MS ( ESI, positive): m/z 134 [M+H]+.
References
[1] Journal of Organic Chemistry, 2002, vol. 67, # 5, p. 1536 - 1547
[2] Helvetica Chimica Acta, 1957, vol. 40, p. 1531,1544
[3] Journal of Organic Chemistry, 1997, vol. 62, # 21, p. 7364 - 7375
[4] Journal of Organic Chemistry, 2003, vol. 68, # 26, p. 10046 - 10057
[5] Journal of the American Chemical Society, 2007, vol. 129, # 18, p. 6017 - 6021
H-D-ALLO-THR-OME HCL Preparation Products And Raw materials
H-D-ALLO-THR-OME HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Nanjing Fred Technology Co., Ltd. | +86-02584696168 15380713688 | Austin@fredchem.cn | CHINA | 865 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 12830 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
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