D-Leucine methyl ester hydrochloride
- CAS No.
- 5845-53-4
- Chemical Name:
- D-Leucine methyl ester hydrochloride
- Synonyms
- H-D-Leu-OMe;eu-OMe·HCL;H-D-LEU-OME HCL;D-LEUCINE-OME HCL;N-METHYL-D-LEUCINE HCL;D-leucinate hydrochloride.;METHYL D-LEUCINATE HYDROCHLORIDE;D-leucine Methy ester hydrochloride;D-LEUCINE METHYL ESTER HYDROCHLORIDE;D-LeucineMethylEsterHydrochloride>
- CBNumber:
- CB3721335
- Molecular Formula:
- C7H15NO2.ClH
- Molecular Weight:
- 181.66
- MDL Number:
- MFCD00066115
- MOL File:
- 5845-53-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| D-Leucine Methyl Ester Hydrochloride >98.0%(N)(T) | L0198 | 1g | $22 |
| D-Leucine Methyl Ester Hydrochloride >98.0%(N)(T) | L0198 | 5g | $71 |
| D-Leucine methyl ester hydrochloride Asreported | 281369 | 5g | $475 |
| D-Leucine methyl ester hydrochloride Asreported | 281369 | 10g | $681 |
| D-Leucine methyl ester hydrochloride Asreported | 281369 | 25g | $970 |
| More product size | |||
| Melting point | 150 °C |
|---|---|
| alpha | -13.5 º (c=5, H2O) |
| refractive index | -14 ° (C=2, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-white to white |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| InChI | InChI=1/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t6-;/s3 |
| InChIKey | DODCBMODXGJOKD-FYZOBXCZSA-N |
| SMILES | [C@@H](N)(CC(C)C)C(=O)OC.Cl |&1:0,r| |
| CAS DataBase Reference | 5845-53-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H319-H413-H372 |
| Precautionary statements | P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Safety Statements | 24/25 |
| HS Code | 29224999 |
D-Leucine methyl ester hydrochloride price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | L0198 | D-Leucine Methyl Ester Hydrochloride >98.0%(N)(T) | 5845-53-4 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | L0198 | D-Leucine Methyl Ester Hydrochloride >98.0%(N)(T) | 5845-53-4 | 5g | $71 | 2026-04-30 | Buy |
| Usbiological | 281369 | D-Leucine methyl ester hydrochloride Asreported | 5845-53-4 | 5g | $475 | 2026-06-03 | Buy |
| Usbiological | 281369 | D-Leucine methyl ester hydrochloride Asreported | 5845-53-4 | 10g | $681 | 2026-06-03 | Buy |
| Usbiological | 281369 | D-Leucine methyl ester hydrochloride Asreported | 5845-53-4 | 25g | $970 | 2026-06-03 | Buy |
D-Leucine methyl ester hydrochloride Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
D-Leucine methyl ester hydrochloride is a protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci in culture. D-Leucine causes analgesia in humans and also exhibits inhibitory activity in bacterial cell cultures.
Synthesis
67-56-1
328-38-1
5845-53-4
The general procedure for the synthesis of methyl (R)-2-amino-4-methylpentanoate hydrochloride from methanol and D-leucine was as follows: according to the method of SG Davies, HJ Sanganee, P. Szolcsányi in Tetrahedron 55 (1999) 3337, the procedure was as follows: D-leucine (60.24 mmol) was was suspended in anhydrous methanol (100 mL) and cooled to 0°C in an ice/salt bath. Thionyl chloride (SOCl2, 5.1 mL, 70.24 mmol) was added slowly and dropwise over 30 min. After removing the cooling bath, the reaction mixture was warmed to room temperature and stirred for 4 hours. Subsequently, the reaction mixture was concentrated under reduced pressure. The resulting white product was suspended in dichloromethane (DCM, 3 x 100 mL) and the solvent was removed by distillation under reduced pressure, a process repeated three times. The white crystalline compound was suspended in ethyl acetate (100 mL), filtered and the solid was washed with ethyl acetate (3 x 20 mL). The white product was dried to constant weight to give white powdered (R)-2-amino-4-methylpentanoic acid methyl ester hydrochloride in 92% yield. The product was characterized as follows: white solid; 92% yield; melting point 149.8-151.5 °C; [αD20] = -12.9° (c 1 , H2O).IR (ATR): 2957, 2921, 2842, 2632, 1731, 1588, 1506, 1451, 1248, 1225, 1040 cm-1.1H NMR ( 400 MHz, D2O): δ 4.10 (1H, t, J = 8 Hz, NH-CH-CH2- CH-(CH3)2), 3.79 (3H, s, O-CH3), 1.85-1.75 (1H, m, NH-CH-CH2- CH-(CH3)2), 1.75-1.62 (2H, m, NH-CH-CH2-CH -(CH3)2, NH-CH-CH2-CH-(CH3)2), 0.96-0.87 (6H, m, CH3-CH-CH3).13C NMR (100.79 MHz, D2O): δ 171.5, 53.6, 51.6, 38.9, 24.1, 21.6, 21.1.Elemental analysis: of C7H15N3O2 Calculated values (181.66): C, 46.28; H, 8.88; N, 7.71; Measured values: C, 45.99±0.03; H, 8.74±0.02; N, 7.69±0.02. HRMS: m/z Calculated values for C7H15N3O2: 146.11756 [M + H]+; Measured values: 146.11762 [M + H H]+.
References
[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 34, p. 10113 - 10117
[2] Angew. Chem., 2016, vol. 128, p. 10267 - 10271,5
[3] Synlett, 2009, # 15, p. 2487 - 2491
[4] Liebigs Annalen der Chemie, 1985, vol. 1985, # 11, p. 2285 - 2300
[5] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 142 - 158
D-Leucine methyl ester hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-15680023009 | ni@enlaibio.com | China | 1103 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3004 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
View Lastest Price from D-Leucine methyl ester hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | D-Leu-Ome.Hcl
5845-53-4
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2020-01-08 | D-Leucine methyl ester hydrochloride
5845-53-4
|
$2.00 | 1KG | 98% | 100g , 1kg, 5kg , 50kg | Career Henan Chemical Co |
-
- D-Leu-Ome.Hcl
5845-53-4
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- D-Leucine methyl ester hydrochloride
5845-53-4
- $2.00
- 98%
- Career Henan Chemical Co
