Acolbifene
- CAS No.
- 151533-34-5
- Chemical Name:
- Acolbifene
- Synonyms
- Acolbifene;(Rac)-EM-652;rac-Acolbifene;(Rac)-Acolbifene, 10 mM in DMSO;2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-;2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran
- CBNumber:
- CB22451259
- Molecular Formula:
- C29H31NO4
- Molecular Weight:
- 457.56
- MDL Number:
- MFCD09837712
- MOL File:
- 151533-34-5.mol
- MSDS File:
- SDS
| Boiling point | 651.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.217±0.06 g/cm3(Predicted) |
| solubility | DMSO: 100 mg/mL (218.55 mM) |
| pka | 9.70±0.40(Predicted) |
| form | Crystal |
| color | Purple to purplish red |
| FDA UNII | 815LJ9X0D1 |
Acolbifene price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BGA53334 | rac-Acolbifene | 151533-34-5 | 5mg | $250 | 2026-06-04 | Buy |
| Biosynth | BGA53334 | rac-Acolbifene | 151533-34-5 | 10mg | $323.9 | 2026-06-04 | Buy |
| Biosynth | BGA53334 | rac-Acolbifene | 151533-34-5 | 25mg | $607 | 2026-06-04 | Buy |
| Biosynth | BGA53334 | rac-Acolbifene | 151533-34-5 | 50mg | $971.5 | 2026-06-04 | Buy |
| Biosynth | BGA53334 | rac-Acolbifene | 151533-34-5 | 100mg | $1555 | 2026-06-04 | Buy |
Acolbifene Chemical Properties, Uses, Production
Description
The prodrug EM-800 is an orally active nonsteroidal anties trogen and is a triphenylethylene rigid analogue. EM-800 undergoes ester hydrolysis to the active m etabolite acolbifene. This fourth-generation antiestrogen is 200-fold more potent than tam oxifen in breast and uterine cancer cells and is effective in patients for whom tamoxifen therapy has failed. The mechanistic rationale for the effectiveness of acolbifene in tamoxifen-resistant tumors is based on the fact that it inhibits both the AF-1 and AF-2 activation pathways and does not poss ess any intrinsic estrogenic action. Acolbifene enjoys a 60% breast cancer cure rate. Structurally, acolbifene resembles raloxifene, with a benzopyran ring substituted for the benz othiophene ring. An additional benefit observed with acolbifene is its protective effect on bone loss. Adverse effects include nausea and vomiting.
Uses
rac-Acolbifene is a reacemic compound of Acolbifene (A190230) which is a selective estrogen receptor modulator (SERM) acting as pure antiestrogen. Acolbifene is also the orally active antiestrogen which is the most potent of the known antiestrogens and exerts pure antiestrogenic activity in the mammary gland and endometrium.
in vivo
(Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice)[1].
Acolbifene Preparation Products And Raw materials
Raw materials
Preparation Products
Acolbifene Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
View Latest Price from Acolbifene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | (Rac)-Acolbifene
151533-34-5
|
$43.00-78.00 | 99.70% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | (Rac)-Acolbifene
151533-34-5
|
$43.00-78.00 | 99.70% | 10g | TargetMol Chemicals Inc. |
-
- (Rac)-Acolbifene
151533-34-5
- $43.00-78.00
- 99.70%
- TargetMol Chemicals Inc.
-
- (Rac)-Acolbifene
151533-34-5
- $43.00-78.00
- 99.70%
- TargetMol Chemicals Inc.
