4-(Chloromethyl)-2-methylpyridine
- CAS No.
- 75523-42-1
- Chemical Name:
- 4-(Chloromethyl)-2-methylpyridine
- Synonyms
- 4-(Chloromethyl)-2-picoline;2-Methyl-4-(chloromethyl)pyridine;4-(Chloromethyl)-2-methylpyridine;4-Chloromethyl-2-methyl-pyridine.HCL;2-methyl-pyridin-4-ylmethyl chloride;pyridine, 4-(chloroMethyl)-2-Methyl-;2-Methyl-4-(chloromethyl)pyridine (HCl)
- CBNumber:
- CB22454432
- Molecular Formula:
- C7H8ClN
- Molecular Weight:
- 141.6
- MDL Number:
- MFCD10697557
- MOL File:
- 75523-42-1.mol
- MSDS File:
- SDS
4-(Chloromethyl)-2-methylpyridine price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00G57C | 4-Chloromethyl-2-methylpyridine | 75523-42-1 | 500mg | $764 | 2026-05-28 | Buy |
| ACHEMBLOCK | S74219 | 4-(chloromethyl)-2-methylpyridine 97% | 75523-42-1 | 250MG | $220 | 2026-05-27 | Buy |
| ACHEMBLOCK | S74219 | 4-(chloromethyl)-2-methylpyridine 97% | 75523-42-1 | 1G | $660 | 2026-05-27 | Buy |
| ACHEMBLOCK | S74219 | 4-(chloromethyl)-2-methylpyridine 97% | 75523-42-1 | 5G | $1715 | 2026-05-27 | Buy |
| AccelPharmtech | D2223 | 4-(chloromethyl)-2-methyl-Pyridine 97.00% | 75523-42-1 | 1G | $2100 | 2026-05-21 | Buy |
4-(Chloromethyl)-2-methylpyridine Chemical Properties,Uses,Production
Uses
4-Chloromethyl-2-methylpyridine is used in the preparation of HIV-1 protease inhibitors.
Synthesis
4-(Chloromethyl)-2-methylpyridine is synthesised using (2-Methylpyridin-4-yl)methanol as a raw material by chemical reaction. The specific synthesis steps are as follows:
5-[(2-Chlorophenyl)acetylamino]-3-(4-fluorophenyl)-4-[4-(2-methylpyridyl)]isoxazole a) 4-Chloromethyl-2-methylpyridine; Into 100 mL of methylene chloride solution containing 2. 1-6 g of 4-(2-methylpyridyl)methanol (cf. PCT International Publication WO98/2120 Pamphlet), 23 mL of thionyl chloride was dropped at room temperature, followed by 20 hours' stirring at room temperature. The solvent was distilled off from the reaction solution under reduced pressure, and the residue was extracted with methylene chloride, after addition of saturated aqueous NaHCO3 solution. The methylene chloride extract was dried over anhydrous magnesium sulfate, and from which the solvent was distilled off under reduced pressure to provide 2.46 g (yield: 100%) of brown crystalline title compound. 1H-NMR(CDCl3)delta:8.45(d,J=5.0Hz,1H),7.31(s,1H), 7.25(d,J=5.0Hz,1H),4.74(s,2H),2.48(s,3H) Mass,m/e:141 (M+,base).
4-(Chloromethyl)-2-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Jiaxing Deyi Chemical Co., Ltd. | 86-0573-85866609 18367600069 | 945717149@qq.com | China | 9507 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6736 | 58 |
| Jinan chemkey pharmaceutical Co., Ltd. | 15610156652 | baimingshi@163.com | China | 973 | 58 |
| Nanjing SynTitan Pharmaceutical Co., Ltd. | 025-57027686 17372956142 | li_lan@syntitan.com | China | 9999 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
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