1-(5-bromothiophen-3-yl)ethanone
- CAS No.
- 59227-67-7
- Chemical Name:
- 1-(5-bromothiophen-3-yl)ethanone
- Synonyms
- 1-(5-Bromothiophen-3-yl);4-Acetyl-2-bromothiophene;3-Acetyl-5-bromothiophene;1-(5-bromo-3-thienyl)ethanone;Ethanone, 1-(5-bromo-3-thienyl)-;1-(5-bromothiophen-3-yl)ethanone;1-(5-broMothiophen-3-yl)ethan-1-one;1-(5-Bromothiophen-3-yl)ethanone - [B71010]
- CBNumber:
- CB22484471
- Molecular Formula:
- C6H5BrOS
- Molecular Weight:
- 205.07
- MDL Number:
- MFCD16659624
- MOL File:
- 59227-67-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H319-H335 |
| Precautionary statements | P261-P301+P310-P305+P351+P338 |
1-(5-bromothiophen-3-yl)ethanone price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS32425 | 1-(5-Bromothiophen-3-yl)ethanone 95% | 59227-67-7 | 1g | $190 | 2026-06-04 | Buy |
| Activate Scientific | AS32425 | 1-(5-Bromothiophen-3-yl)ethanone 95% | 59227-67-7 | 5g | $694 | 2026-06-04 | Buy |
| Matrix Scientific | 074324 | 1-(5-Bromothiophen-3-yl)ethanone | 59227-67-7 | 250.00mg | $324 | 2026-05-18 | Buy |
| Matrix Scientific | 074324 | 1-(5-Bromothiophen-3-yl)ethanone | 59227-67-7 | 1.00g | $700 | 2026-05-18 | Buy |
| Matrix Scientific | 074324 | 1-(5-Bromothiophen-3-yl)ethanone | 59227-67-7 | 5.00g | $1750 | 2026-05-18 | Buy |
1-(5-bromothiophen-3-yl)ethanone Chemical Properties,Uses,Production
Uses
1-(5-Bromothiophen-3-yl)ethanone is a useful research chemical for the preparation of acifran analogs as agonists of niacin receptors, GPR109a and GPR109b for the treatment of atherosclerosis.
Synthesis
1468-83-3
59227-67-7
The general procedure for the synthesis of 1-(5-bromothiophen-3-yl)ethanone from 3-acetylthiophene is as follows: to a solution of acetic acid (50 mL) containing 3-acetylthiophene (2.52 g, 20 mmol, 1.0 eq.), sodium acetate (2.46 g, 30 mmol, 1.5 eq.) and bromine (3.2 g, 20 mmol, 1.0 eq.) are added sequentially, the bromine The addition of bromine was controlled to be completed within 30 minutes. The reaction mixture was stirred at room temperature overnight. Subsequently, water (150 mL) was added to the reaction system and stirring was continued for 2 hours. The resulting solid product was collected by filtration, washed sequentially with water (10 mL) and petroleum ether (20 mL), and dried to afford the target compound 1-(5-bromothiophen-3-yl)ethanone (8i-2) as a brown solid (1.52 g, 37% yield).
References
[1] Synthetic Communications, 1981, vol. 11, # 1, p. 29 - 34
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 19, p. 5849 - 5853
[3] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 296
[4] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 11, p. 897 - 902
[5] Patent: US2003/114666, 2003, A1
1-(5-bromothiophen-3-yl)ethanone Preparation Products And Raw materials
1-(5-bromothiophen-3-yl)ethanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 | |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai Boyners Pharm-Tech Co., Ltd. | 13817873692 | mkt@boynerspharm.com | China | 1707 | 55 |
| DebyeTec.com Inc. | 18086626237 18086626237 | 2693528373@qq.com | China | 2937 | 56 |
| Shanghai RenYue Chemical Technology Co., Ltd. | 021-62219190; 18321139117 | 316441092@qq.com | China | 3000 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
