3-Acetylthiophene
- CAS No.
- 1468-83-3
- Chemical Name:
- 3-Acetylthiophene
- Synonyms
- 1-(thiophen-3-yl)ethan-1-one;Acetylthiophene;3-Acetyl;3-Acetylthioph;Acetylthio[hene;3-Acetylthiophen;3-ACETYLTHIOPHENE;Acetylthiophene,97%;Acetylthiophene,95%;3-Acetylthiophene99%
- CBNumber:
- CB4434894
- Molecular Formula:
- C6H6OS
- Molecular Weight:
- 126.18
- MDL Number:
- MFCD00005468
- MOL File:
- 1468-83-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 57-62 °C (lit.) |
|---|---|
| Boiling point | 208-210 °C/748 mmHg (lit.) |
| Density | 1.176 (estimate) |
| refractive index | 1.5667 (estimate) |
| Flash point | 208-210°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Hexane (Slightly) |
| form | Adhering Crystals |
| color | Beige to light brown |
| Sensitive | Light Sensitive |
| BRN | 107241 |
| InChI | 1S/C6H6OS/c1-5(7)6-2-3-8-4-6/h2-4H,1H3 |
| InChIKey | RNIDWJDZNNVFDY-UHFFFAOYSA-N |
| SMILES | CC(=O)c1ccsc1 |
| LogP | 1.240 |
| CAS DataBase Reference | 1468-83-3(CAS DataBase Reference) |
| FDA UNII | XB5SQX2RBW |
| NIST Chemistry Reference | Ethanone, 1-(3-thienyl)-(1468-83-3) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H302-H312-H331 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P501-P280h-P304+P340-P311a-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36/37-36-26 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3-Acetylthiophene price More Price(94)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 196320 | 3-Acetylthiophene 98% | 1468-83-3 | 10g | $137 | 2026-04-30 | Buy |
| TCI Chemical | A1006 | 3-Acetylthiophene >95.0%(GC) | 1468-83-3 | 10g | $95 | 2026-04-30 | Buy |
| TCI Chemical | A1006 | 3-Acetylthiophene >95.0%(GC) | 1468-83-3 | 25g | $166 | 2023-01-07 | Buy |
| Usbiological | 258125 | 3-Acetylthiophene Asreported | 1468-83-3 | 5g | $337 | 2026-06-03 | Buy |
| Usbiological | 258125 | 3-Acetylthiophene Asreported | 1468-83-3 | 10g | $482 | 2026-06-03 | Buy |
3-Acetylthiophene Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Acetylthiophene was used in the preparation of 1-(methylthiophenylidine)-8-naphthylamine(Schiff′s base) and 1-(thiophen-3-yl)ethanone.
Definition
ChEBI: 3-Acetylthiophene is an aromatic ketone.
General Description
3-Acetylthiophene modified glassy carbon electrode has been used in voltammetric determination of uric acid in urine samples.
Synthesis
67237-53-0
1468-83-3
The general procedure for the synthesis of 3-acetylthiophene from 3-ethynylthiophene was as follows: a mixture of 3-ethynylthiophene (232 mg, 2.0 mmol) and S-COPNA (NP) resin (59 mg, 0.2 mmol) in H2O (4 mL) was subjected to refluxing conditions (bath temperature of 120°C) and the reaction was stirred for 8 h at 600 rpm. After completion of the reaction, the catalyst was removed by filtration and washed sequentially with H2O and heptane. A drop of saturated NaHCO3 solution was added to the organic layer, followed by evaporation of the organic solvent under reduced pressure. The residue was purified by column chromatography using heptane-acetone (20:1) as eluent to give finally 3-acetylthiophene (225 mg, 84% yield).
Purification Methods
Recrystallise the thiophene from pet ether (b 30-60o) or EtOH. The 2,4-dinitrophenylhydrazone crystallises from CHCl3, m 265o, and the semicarbazone crystallises from EtOH, m 174-175o. [Campaigne & Le Suer J Am Chem Soc 70 1555 1948, Beilstein 17/9 V 399.]
References
[1] Applied Organometallic Chemistry, 2012, vol. 26, # 12, p. 722 - 726
[2] Tetrahedron Letters, 2017, vol. 58, # 10, p. 955 - 958
[3] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1444 - 1447
[4] ChemSusChem, 2013, vol. 6, # 3, p. 430 - 432
3-Acetylthiophene Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 726 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Lastest Price from 3-Acetylthiophene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 3-Acetylthiophene
1468-83-3
|
$1.00 | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | 3-Acetylthiophene
1468-83-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-10-14 | 3-Acetylthiophene
1468-83-3
|
$10.00 | 1KG | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- 3-Acetylthiophene
1468-83-3
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Acetylthiophene
1468-83-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-Acetylthiophene
1468-83-3
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
