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ChemicalBook >> CAS DataBase List >>α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol

α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol

α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Structure
α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol structure
CAS No.
176721-01-0
Chemical Name:
α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
Synonyms
Dexmedetomidine Impurity 28;α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methan;(2,3-diMethylphenyl)(1-trityl-1H-iMidazol-4-yl)Methanol;(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol;(2,3-Dimethylphenyl)-(3-trityl-3H-imidazol-4-yl)methanol;α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol;alpha-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol;alpha-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methano...;1-(2,3-dimethylphenyl)-1-(1H-imidazol-4-triphenylmethyl)methanol;α-(2,3-Dimethylphenyl)-1-(triphenylmethyl)-1H-imidazole-4-methanol
CBNumber:
CB22508434
Molecular Formula:
C31H28N2O
Molecular Weight:
444.57
MDL Number:
MFCD23135354
MOL File:
176721-01-0.mol
MSDS File:
SDS
Last updated:2026-05-28 00:01:02
Product description Number Pack Size Price
a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 272725 25mg $446
a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 272725 50mg $679
a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 272725 100mg $1044
a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 272725 250mg $1649
a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 272725 500mg $2697
Request For Quotation

α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Properties

Melting point 180 - 184°C
Boiling point 616.0±50.0 °C(Predicted)
Density 1.09±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated)
pka 13.08±0.20(Predicted)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)Skull and Crossbones (GHS06)
GHS08,GHS06
Signal word  Danger
Hazard statements  H362-H319-H361-H301
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P201-P202-P281-P308+P313-P405-P501-P201-P260-P263-P264-P270-P308+P313-P264-P270-P301+P310-P321-P330-P405-P501

α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 272725 a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 176721-01-0 25mg $446 2026-06-03 Buy
Usbiological 272725 a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 176721-01-0 50mg $679 2026-06-03 Buy
Usbiological 272725 a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 176721-01-0 100mg $1044 2026-06-03 Buy
Usbiological 272725 a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 176721-01-0 250mg $1649 2026-06-03 Buy
Usbiological 272725 a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Asreported 176721-01-0 500mg $2697 2026-06-03 Buy
Product number Packaging Price Buy
272725 25mg $446 Buy
272725 50mg $679 Buy
272725 100mg $1044 Buy
272725 250mg $1649 Buy
272725 500mg $2697 Buy

α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol is an Intermediate in the production of Medetomidine

Synthesis

2,3-Dimethylbromobenzene

576-23-8

1-Tritylimidazole-4-carboxaldehyde

33016-47-6

α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol

176721-01-0

1. 11.5 g (60.2 mmol) of 1-bromo-2,3-dimethylbenzene was dissolved in 200 mL of anhydrous tetrahydrofuran (THF) in a dry reaction flask. 2. a mixed system consisting of 1.5 g (61.7 mmol) of magnesium strips, 0.05 g of iodine, and 50 mL of anhydrous THF was slowly added dropwise to initiate the preparation of Grignard's reagent. 3. After dropwise addition, the reaction system was heated to reflux and maintained at reflux for 1 hour to ensure complete reaction. 4. After completion of the reaction, the system was cooled to room temperature to obtain a solution of 2,3-dimethylphenylmagnesium bromide Grignard reagent. 5. In another dry reaction flask, 17.5 g (50.2 mmol) of 1-tritylimidazole-4-carbaldehyde was dissolved in 225 mL of anhydrous THF and this solution was cooled to 0 °C. The reaction was carried out at 0 °C. 6. The Grignard reagent solution prepared in step 4 was slowly added to the aldehyde solution at 0 °C, with controlled drop acceleration to maintain the reaction temperature. 7. After the addition is complete, the reaction mixture is stirred at room temperature for 1.5 hours to complete the nucleophilic addition reaction. 8. The reaction was quenched using saturated aqueous ammonium chloride solution and then most of the THF was removed by concentration under reduced pressure. 9. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. 10. The crude product was dissolved in dichloromethane and after removing most of the solvent by concentration under reduced pressure, the residue was cooled to -5 °C and kept for 1 hour to promote crystallization. 11. The crystals were collected by filtration, washed with cold dichloromethane and dried to give 12.4 g of (2,3-dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol in 53.9% yield.

References

[1] Patent: CN108147999, 2018, A. Location in patent: Paragraph 0162; 0163
[2] Synthetic Communications, 1996, vol. 26, # 8, p. 1585 - 1593
[3] Journal of the Iranian Chemical Society, 2017, vol. 14, # 8, p. 1735 - 1739

α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Preparation Products And Raw materials

Raw materials

2,3-Dimethylbromobenzene 2,3-Dimethylbenzaldehyde 4-Iodo-1-tritylimidazole 1-Tritylimidazole-4-carboxaldehyde Magnesium
iodine Tetrahydrofuran

1of2

Preparation Products

5-[1-(2,3-DiMethylphenyl)ethenyl]iMidazole (2,3-Dimethylphenyl)[1-(trityl)-1H-imidazol-4-yl]methanone

α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Suppliers

Global( 68)Suppliers
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Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3004 60
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14320 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd 		029-81140587 sales@yutbon.com China 452 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29096 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +86-18949823763 sales@tnjchem.com China 25333 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +8619957148339 market18@leapchem.com China 24569 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49860 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +86-15965530500 nickzhang@hangyubiotech.com China 9937 58
Supplier Advantage
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Standardpharm Co. Ltd. 		58
career henan chemical co 		58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd 		58
Dideu Industries Group Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
GIHI CHEMICALS CO.,LIMITED 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58

View Lastest Price from α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol pictures 2020-02-23 α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
176721-01-0
 $3.00 1KG 98% 100KG Career Henan Chemical Co

176721-01-0(α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol)Related Search:

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Medetomidine Impurity 14 (2,3-Dimethylphenyl)[1-(trityl)-1H-imidazol-4-yl]methanone 2-(2,3-DIMETHYLPHENYL)ETHANOL Demiditraz racemate IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE
1-(2,3-Dimethylphenyl)ethyl chloride 2,3-DIMETHYLACETOPHENONE Medetomidine Impurity 3 3,4-Dimethylbromobenzene 2,3-Dimethylbenzyl chloride
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1-(2,3-dimethylphenyl)-1-(1H-imidazol-4-triphenylmethyl)methanol alpha-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol (2,3-diMethylphenyl)(1-trityl-1H-iMidazol-4-yl)Methanol 1H-IMidazole-4-Methanol, α-(2,3-diMethylphenyl)-1-(triphenylMethyl)- (2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol (2,3-Dimethylphenyl)-(3-trityl-3H-imidazol-4-yl)methanol Dexmedetomidine Impurity 28 α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methan alpha-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methano... α-(2,3-Dimethylphenyl)-1-(triphenylmethyl)-1H-imidazole-4-methanol alpha-(2,3-Dimethylphenyl)-1-(triphenylmethyl)-1H-imidazol-4-methanol α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol, CAS 176721-01-0 176721-01-0 Heterocycles Intermediates & Fine Chemicals Pharmaceuticals