Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate
- CAS No.
- 323176-93-8
- Chemical Name:
- Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate
- Synonyms
- Venlafaxine EP IMpurity B;Venlafaxine IMpurity B;Venlafaxine EP Impurity B HCl;Ethyl (2RS)-3-(Dimethylamino)-2-(4-;ethyl 3-(dimethylamino)-2-(4-methoxyphenyl);ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate;Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate;Ethyl 3-Dimethylamino-2-(4-methoxy-phenyl)-propionate;Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate;Venlafaxine EP Impurity B (Venlafaxine Ester Impurity)
- CBNumber:
- CB22508656
- Molecular Formula:
- C14H21NO3
- Molecular Weight:
- 251.32
- MDL Number:
- MFCD16293840
- MOL File:
- 323176-93-8.mol
- MSDS File:
- SDS
| Boiling point | 337.9±42.0 °C(Predicted) |
|---|---|
| Density | 1.045±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 8.61±0.28(Predicted) |
| color | Pale Brown to Light Brown |
| FDA UNII | 20A3002JTT |
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-E925055-50MG | Ethyl alpha-(p-Methoxyphenyl)-beta-(dimethylamino)propionate >95%(HPLC) | 323176-93-8 | 50mg | $278 | 2026-06-03 | Buy |
| TRC | TRC-E925055-500MG | Ethyl alpha-(p-Methoxyphenyl)-beta-(dimethylamino)propionate >95%(HPLC) | 323176-93-8 | 500mg | $1983 | 2026-06-03 | Buy |
| Biosynth | IE63864 | Ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate | 323176-93-8 | 5mg | $178.5 | 2026-06-04 | Buy |
| Biosynth | IE63864 | Ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate | 323176-93-8 | 10mg | $290.3 | 2026-06-04 | Buy |
| Biosynth | IE63864 | Ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate | 323176-93-8 | 25mg | $453.75 | 2026-06-04 | Buy |
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Chemical Properties, Uses, Production
Synthesis
A mixture of ethyl p-methoxyphenylacetate (4 g, 20.62 mmol), paraformaldehyde (1.05 g, 35.0 mmol) and TBAI (0.381 g, 1.03 mmol) was heated in PhMe (16 ml) at 80-85 ºC for 3.5 hours. The reaction mixture was allowed to cool. Then, a solution of Me2NH in THF was added to the reaction mixture at 0 ºC in the presence of catalytic FeCl3 (0.160 g, 0.001 mol) and stirred for 45 minutes. After completion of the reaction, 100 ml water was added to the reaction mixture and aqueous layer was acidified with conc. HCl (pH = 2). Aqueous layer was washed with DCM (3x 50 ml) and made alkaline (pH = 8) using 5% NaOH solution, extracted with DCM (3x 50 ml), washed with water, brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Column chromatographic purification over silca gel (0.5% MeOH in CHCl3) furnished aminoester 65 as a thick colourless oil (3.08 g). When the reaction was carried out without catalyst, it took 48 hours for completetion.
Uses
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate (Venlafaxine EP Impurity B) is an impurity of Venlafaxine (impurity B).
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Tonichem Pharmaceutical Technology Co., Ltd. | +86 (0752) 222-7171, +86 15815821171 | China | 1117 | 58 | |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-0371-55629727 13323845623 | 2885676761@qq.com | China | 9957 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
| Shanghai XunTang Chemical Technology Co., Ltd. | 15900811974 | 546264981@qq.com | China | 97 | 58 |
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