O-Desmethylvenlafaxine
- CAS No.
- 93413-62-8
- Chemical Name:
- O-Desmethylvenlafaxine
- Synonyms
- desvenlafaxine;DVS 233;Wy-45233;Desvenlafaxine Base;Effexor Impurity 36;Desmethylvenlafaxine;O-desMethylvenlafaxin;O-Desmethylvenlafaxine;Venlafxine-O-Desmethyl;Venlafaxine Impurity 36
- CBNumber:
- CB8496834
- Molecular Formula:
- C16H25NO2
- Molecular Weight:
- 263.38
- MDL Number:
- MFCD00871934
- MOL File:
- 93413-62-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 208-213°C |
|---|---|
| Boiling point | 403.8±25.0 °C(Predicted) |
| Density | 1.115±0.06 g/cm3(Predicted) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH |
| pka | 10.04±0.26(Predicted) |
| form | Solid |
| color | White to off-white |
| Major Application | clinical testing |
| InChI | 1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3 |
| InChIKey | KYYIDSXMWOZKMP-UHFFFAOYSA-N |
| SMILES | N(CC(C2(CCCCC2)O)c1ccc(cc1)O)(C)C |
| LogP | 0.33 at 25℃ and pH6 |
| FDA UNII | NG99554ANW |
| ATC code | N06AX23 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | F,T,Xi | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25-36 | |||||||||
| Safety Statements | 7-16-36/37-45-26 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GV8872620 | |||||||||
| HS Code | 29225090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| Hazardous Substances Data | 93413-62-8(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
O-Desmethylvenlafaxine price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V-045 | O-Desmethylvenlafaxine solution 1.0?mg/mL in methanol, certified reference material, Cerilliant? | 93413-62-8 | 1mL | $456 | 2026-04-30 | Buy |
| Sigma-Aldrich | V-007 | O-Desmethylvenlafaxine solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 93413-62-8 | 1mL | $101 | 2026-04-30 | Buy |
| TCI Chemical | D5598 | O-Desmethylvenlafaxine | 93413-62-8 | 1G | $97 | 2026-04-30 | Buy |
| TCI Chemical | D5598 | O-Desmethylvenlafaxine | 93413-62-8 | 5G | $292 | 2026-04-30 | Buy |
| Cayman Chemical | 9001881 | (±)-O-Desmethyl Venlafaxine ≥98% | 93413-62-8 | 5mg | $80 | 2026-04-30 | Buy |
O-Desmethylvenlafaxine Chemical Properties, Uses, Production
Description
Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.
Chemical Properties
White Solid
Originator
Wyeth (United States)
Uses
A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant
Uses
A metabolite of Venlafaxine (V120000), a selective serotonin noradrenaline reuptake inhibitor (SNRI). Used as an antidepressant.
Uses
a metabolite of Venlafaxine .;Labeled Venlafaxine, intended for use as an internal standard for the quantification of Venlafaxine by GC- or LC-mass spectrometry.
Definition
ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.
brand name
Pristiq
General Description
An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.
Synthesis
Desvenlafaxine is chemically derived from 4-benzyloxyphenylacetic acid, by first converting to the acid chloride with oxalyl chloride and then condensing with dimethylamine to produce the corresponding N,N-dimethyl amide. Deprotonation of the amide with butyllithium, followed by condensation with cyclohexanone gives a b-hydroxyamide intermediate, which is reduced with alane, and debenzylated by using palladium on carbon and 1,4-cyclohexadiene to produce desvenlafaxine.
O-Desmethylvenlafaxine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from O-Desmethylvenlafaxine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Desvenlafaxine
93413-62-8
|
$40.00-73.00 | 99.81% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-02-02 | O-Desmethylvenlafaxine
93413-62-8
|
5mg | 99% HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | O-Desmethylvenlafaxine
93413-62-8
|
$2.00 | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- Desvenlafaxine
93413-62-8
- $40.00-73.00
- 99.81%
- TargetMol Chemicals Inc.
-
- O-Desmethylvenlafaxine
93413-62-8
- 99% HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- O-Desmethylvenlafaxine
93413-62-8
- $2.00
- 99%
- Career Henan Chemical Co
