ChemicalBook >> CAS DataBase List >>1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide structure

CAS No.: 301326-22-7

Chemical Name:: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

Synonyms: CS-2720;CH 223191;NSC264495;NSC 264495;NSC-264495;AhR Antagonist;C8124 CH-223191;CH223191;CH 223191;CH-223191 301326-22-7;CH-223191, 10 mM in DMSO

CBNumber:: CB22518866

Molecular Formula:: C19H19N5O

Molecular Weight:: 333.39

MDL Number:: MFCD00377884

MOL File:: 301326-22-7.mol

MSDS File:: SDS

Last updated:2025-10-17 20:33:23

Product description	Number	Pack Size	Price
CH-223191	C8124	5mg	$114.95
AhR Antagonist	182705	10mg	$233
CH-223191	C4042	10MG	$157
CH-223191	C4042	50MG	$471
CH 223191 ≥95%	16154	5mg	$60
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1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide Properties

Melting point	>164°C (dec.)
Boiling point	469.4±45.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥20mg/mL
form	powder
pka	12.98±0.70(Predicted)
color	orange-brown
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey	LKTNEXPODAWWFM-GHVJWSGMSA-N
FDA UNII	HYE7315Z4C
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

NFPA 704

	0
2		0

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C8124	CH-223191	301326-22-7	5mg	$114.95	2025-07-31	Buy
Sigma-Aldrich	182705	AhR Antagonist	301326-22-7	10mg	$233	2025-07-31	Buy
TCI Chemical	C4042	CH-223191	301326-22-7	10MG	$157	2025-07-31	Buy
TCI Chemical	C4042	CH-223191	301326-22-7	50MG	$471	2025-07-31	Buy
Cayman Chemical	16154	CH 223191 ≥95%	301326-22-7	5mg	$60	2024-03-01	Buy

Product number	Packaging	Price	Buy
C8124	5mg	$114.95	Buy
182705	10mg	$233	Buy
C4042	10MG	$157	Buy
C4042	50MG	$471	Buy
16154	5mg	$60	Buy

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide Chemical Properties,Uses,Production

Description

CH-221391 (CAS 301326-22-7) is an arylhydrocarbon (AhR) receptor antagonist, IC50=30 nM.1 Blocks endogenous AhR agonist-induced differentiation of Th17 cells.2?? Promotes expansion of human hematopoietic stem cells.3 Mitigates cytokine-mediated inflammatory signaling in human fibroblast-like synoviocytes.4 An important tool for probing the involvement of AhR in the toxicity of various environmental toxins such as TCDD and other dioxins.5

Uses

CH-223191 has been used as aryl hydrocarbon receptor (AHR) antagonist in HepaRG cells, TH17-IL-10+ cells and organoids.

Definition

ChEBI: 2-methyl-N-[2-methyl-4-(2-methylphenyl)azophenyl]-3-pyrazolecarboxamide is an aromatic amide.

Biochem/physiol Actions

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It inhibited TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibited TCDD-induced luciferase activity with an IC50 of 30nM. Unlike some other AhR antagonists which display agonist activity at high concentrations, CH-223191 did not stimulate AhR-dependent transcription even at 100 micromolar. It is also specific for AhR, displaying no affinity for the estrogen receptor, as some other antagonists do.

storage

Store at +4°C

References

[1] SUN-HEE KIM. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.[J]. Molecular Pharmacology, 2006, 69 6: 1871-1878. DOI:10.1124/mol.105.021832
[2] MARC VELDHOEN. Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells.[J]. ACS Chemical Health & Safety, 2009: 43-49. DOI:10.1084/jem.20081438
[3] STEPHEN M. CARLIN John J M David D Ma. T-cell potential of human adult and cord blood hemopoietic stem cells expanded with the use of aryl hydrocarbon receptor antagonists[J]. Cytotherapy, 2013, 15 2: Pages 224-230. DOI:10.1016/j.jcyt.2012.10.014
[4] TEJAS S LAHOTI. Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes.[J]. Annals of the Rheumatic Diseases, 2013, 72 10: 1708-1716. DOI:10.1136/annrheumdis-2012-202639
[5] BRIAN K. PETROFF . The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) alters early embryonic development in a rat IVF exposure model[J]. Reproductive toxicology, 2011, 32 3: Pages 286-292. DOI:10.1016/j.reprotox.2011.07.005

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide Suppliers

Global( 164)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12247	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32434	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20342	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58

Supplier	Advantage
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei Jusheng Technology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
CD Chemical Group Limited	58

View Lastest Price from 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-17	CH-223191 301326-22-7	US $56.00-178.00 / mg		99.71%	10g	TargetMol Chemicals Inc.
2025-09-12	1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide 301326-22-7	US $0.00 / KG	1KG	99%	50000KG/month	Sichuan Zhuoyu Yantang Technology Co., Ltd.
2025-06-27	CH-223191 301326-22-7	US $0.00 / G	1G	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

CH-223191
301326-22-7
US $56.00-178.00 / mg
99.71%
TargetMol Chemicals Inc.

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide
301326-22-7
US $0.00 / KG
99%
Sichuan Zhuoyu Yantang Technology Co., Ltd.

CH-223191
301326-22-7
US $0.00 / G
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide Spectrum

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide(301326-22-7)¹HNMR

301326-22-7(1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide)Related Search:

CIGLITAZONE Rosiglitazone maleate L-KYNURENINE KL001

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide CH 223191 1-Methyl-N-[2-methyl-4-[(2-methylphenyl)azo]phenyl]-1H-pyrazole-5-carboxamide CH223191;CH 223191 CS-2720 AhR Antagonist 2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide 2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (E)-1-methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamide 2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-c AhR Antagonist - CAS 301326-22-7 - Calbiochem 1H-Pyrazole-5-carboxamide, 1-methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]- 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide USP/EP/BP 1-Methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamide NSC 264495 NSC264495 NSC-264495 CH-223191 301326-22-7 CH-223191, 10 mM in DMSO C8124 CH-223191 301326-22-7 Inhibitors