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2-BroMo-4-(trifluoroMethyl)thiazole

2-BroMo-4-(trifluoroMethyl)thiazole structure

CAS No.: 41731-39-9

Chemical Name:: 2-BroMo-4-(trifluoroMethyl)thiazole

Synonyms: 2-Bromo-4-(trifluoromethyl)thiazol;2-BroMo-4-(trifluoroMethyl)thiazole;Thiazole, 2-broMo-4-(trifluoroMethyl)-;2-bromo-4-(trifluoromethyl)-1,3-thiazole

CBNumber:: CB22550170

Molecular Formula:: C4HBrF3NS

Molecular Weight:: 232.02

MDL Number:: MFCD14702712

MOL File:: 41731-39-9.mol

Last updated:2026-05-28 00:04:41

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2-BroMo-4-(trifluoroMethyl)thiazole Properties

Boiling point	182.8±35.0 °C(Predicted)
Density	1.904±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-2.20±0.10(Predicted)
Appearance	Colorless to light yellow Liquid
InChI	InChI=1S/C4HBrF3NS/c5-3-9-2(1-10-3)4(6,7)8/h1H
InChIKey	NZNVGMVYUYNBOM-UHFFFAOYSA-N
SMILES	S1C=C(C(F)(F)F)N=C1Br

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H335-H319-H302
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362
HS Code	2934100090

2-BroMo-4-(trifluoroMethyl)thiazole price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC201251	2-Bromo-4-(trifluoromethyl)thiazole >97%	41731-39-9	250mg	$21	2026-06-04	Buy
Apolloscientific	PC201251	2-Bromo-4-(trifluoromethyl)thiazole >97%	41731-39-9	1g	$22	2026-06-04	Buy
Apolloscientific	PC201251	2-Bromo-4-(trifluoromethyl)thiazole >97%	41731-39-9	5g	$108	2026-06-04	Buy
Apolloscientific	PC201251	2-Bromo-4-(trifluoromethyl)thiazole >97%	41731-39-9	25g	$521	2026-06-04	Buy
Apolloscientific	PC201251	2-Bromo-4-(trifluoromethyl)thiazole >97%	41731-39-9	100g	$2043	2026-06-04	Buy

Product number	Packaging	Price	Buy
PC201251	250mg	$21	Buy
PC201251	1g	$22	Buy
PC201251	5g	$108	Buy
PC201251	25g	$521	Buy
PC201251	100g	$2043	Buy

2-BroMo-4-(trifluoroMethyl)thiazole Chemical Properties, Uses, Production

Synthesis

349-49-5

41731-39-9

General procedure for the synthesis of 2-bromo-4-(trifluoromethyl)thiazole from 2-amino-4-(trifluoromethyl)thiazole: 2-amino-4-(trifluoromethyl)thiazole (500 mg, purchased from Wako Pure Chemical Industries, Ltd.) was dissolved in a 48% aqueous hydrogen bromide solution (6 mL), and sodium nitrite (266) was added slowly and dropwise, under the cooling of an ice bath. mg) in aqueous sodium nitrite (1 mL) was slowly added dropwise under cooling in an ice bath. The reaction mixture was stirred at 0°C for 1 hour. Subsequently, the reaction was quenched by the addition of aqueous sodium bisulfite, then the pH was adjusted with aqueous sodium hydroxide and finally extracted with ether. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with ethyl acetate-hexane (1:9, v/v) as eluent to give 2-bromo-4-(trifluoromethyl)thiazole (167 mg, 24% yield).1H-NMR (300 MHz, DMSO-d6) δ: 8.55 (s, 1H). Referring to the operation of Example 17 of the starting material synthesis, 1-[4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine hydrochloride (194 mg, 53% yield) was prepared by the reaction of 2-bromo-4-(trifluoromethyl)thiazole (309 mg) with 1-(tert-butoxycarbonyl)piperazine (300 mg).1H-NMR (300 MHz, DMSO-d6) δ: 3.19-3.24 (m, 4H), 3.66-3.75 (m, 4H), 7.68 (s, 1H), 9.57 (brs, 2H).

References

[1] Patent: EP1714961, 2006, A1. Location in patent: Page/Page column 17

2-BroMo-4-(trifluoroMethyl)thiazole Preparation Products And Raw materials

Raw materials

4-Trifluoromethyl-thiazol-2-ylamine Sodium nitrite Hydrogen bromide

Preparation Products

4-Methyl-2-(tributylstannyl)thiazole

2-BroMo-4-(trifluoroMethyl)thiazole Suppliers

Global Suppliers ( 88)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai YuYuan Pharmaceutical Co., Ltd.	13052276172	product@yuyuanpharm.com	China	401	55
Xinyi Kaiwu Chemical Technology Co., Ltd.	0516-0516-88997009 18651776937	4164357@qq.com	China	3204	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	6206333 13167063860	anhua.mao@aladdin-e.com	China	43553	58
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Shanghai yirong biology science and technology co., ltd	18049974220	3060526242@qq.com	China	999	60
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9509	58
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	sales@norris-pharm.com	China	8869	55

Supplier	Advantage
Shanghai YuYuan Pharmaceutical Co., Ltd.	55
Xinyi Kaiwu Chemical Technology Co., Ltd.	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shandong Xiya Chemical Co., Ltd	57
Shanghai yirong biology science and technology co., ltd	60
Shanghai Topbiochem Technology Co., Ltd	58
Nanjing Norris-Pharm Technology Co., Ltd	55

View Latest Price from 2-BroMo-4-(trifluoroMethyl)thiazole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-08	2-BroMo-4-(trifluoroMethyl)thiazole 41731-39-9	$6.60	1KG	98%-99%	1kg-100kg	Career Henan Chemical Co

2-BroMo-4-(trifluoroMethyl)thiazole
41731-39-9
$6.60
98%-99%
Career Henan Chemical Co

2-BroMo-4-(trifluoroMethyl)thiazole Spectrum

2-BroMo-4-(trifluoroMethyl)thiazole(41731-39-9)¹HNMR

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2-BroMo-4-(trifluoroMethyl)thiazole Thiazole, 2-broMo-4-(trifluoroMethyl)- 2-bromo-4-(trifluoromethyl)-1,3-thiazole 2-Bromo-4-(trifluoromethyl)thiazol 41731-39-9 C4HBrF3NS