3-Thiophenecarboxaldehyde, 5-chloro-
- CAS No.
- 36155-85-8
- Chemical Name:
- 3-Thiophenecarboxaldehyde, 5-chloro-
- Synonyms
- 5-chlorothiophene-3-carbaldehyde;5-Chlorothiophene-3-carbo...;5-Chlorothiophene-3-carboxaldehyde;3-Thiophenecarboxaldehyde, 5-chloro-
- CBNumber:
- CB22552846
- Molecular Formula:
- C5H3ClOS
- Molecular Weight:
- 146.59
- MDL Number:
- MFCD17016115
- MOL File:
- 36155-85-8.mol
- MSDS File:
- SDS
| Boiling point | 208.8±20.0 °C(Predicted) |
|---|---|
| Density | 1.429±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| Appearance | light yellow liquid |
| InChI | InChI=1S/C5H3ClOS/c6-5-1-4(2-7)3-8-5/h1-3H |
| InChIKey | BGOGYRKWKJGOHZ-UHFFFAOYSA-N |
| SMILES | C1SC(Cl)=CC=1C=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312-P362+P364 |
| HS Code | 2934999090 |
3-Thiophenecarboxaldehyde, 5-chloro- price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR928325 | 5-Chlorothiophene-3-carboxaldehyde 98% | 36155-85-8 | 100mg | $62 | 2026-06-04 | Buy |
| Apolloscientific | OR928325 | 5-Chlorothiophene-3-carboxaldehyde 98% | 36155-85-8 | 250mg | $74 | 2026-06-04 | Buy |
| Apolloscientific | OR928325 | 5-Chlorothiophene-3-carboxaldehyde 98% | 36155-85-8 | 1g | $184 | 2026-06-04 | Buy |
| Apolloscientific | OR928325 | 5-Chlorothiophene-3-carboxaldehyde 98% | 36155-85-8 | 5g | $551 | 2026-06-04 | Buy |
| Activate Scientific | AS17523 | 5-Chlorothiophene-3-carboxaldehyde 95% | 36155-85-8 | 1g | $227 | 2026-06-04 | Buy |
3-Thiophenecarboxaldehyde, 5-chloro- Chemical Properties, Uses, Production
Uses
5-Chloro-3-thiophenecarboxaldehyde is a useful reagent in the preparation of 2,4-Diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.
Synthesis
498-62-4
36155-85-8
General procedure for the synthesis of 5-chlorothiophene-3-carbaldehyde from 3-thiophenecarboxaldehyde: The reaction was carried out to a solution of thiophene-3-carbaldehyde (20.0 g, 178.3 mmol) and N-chlorosuccinimide (23.8 g, 178.3 mmol) in acetic acid (180 mL) with stirring for 4 hours at 110 °C. After completion of the reaction, the reaction solution was cooled to room temperature, then diluted with ethyl acetate (120 mL), washed sequentially with water (100 mL x 3), saturated sodium bicarbonate solution (50 mL x 2) and brine, and the organic phase was dried with anhydrous sodium sulfate. After concentration under reduced pressure, 5-chlorothiophene-3-carbaldehyde (8.0 g, 54.6 mmol, 31% yield) was obtained as a yellow solid, which could be used for subsequent reactions without further purification.
References
[1] Patent: WO2015/140133, 2015, A1. Location in patent: Page/Page column 110
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 8, p. 2568 - 2578
[3] Patent: WO2015/142903, 2015, A2. Location in patent: Page/Page column 98
3-Thiophenecarboxaldehyde, 5-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
3-Thiophenecarboxaldehyde, 5-chloro- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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