3-broMo-5-fluoro-4-hydroxybenzaldehyde
- CAS No.
- 185345-46-4
- Chemical Name:
- 3-broMo-5-fluoro-4-hydroxybenzaldehyde
- Synonyms
- 3-fluoro-4-hydroxy-5-bromobenzaldehyde;3-broMo-5-fluoro-4-hydroxybenzaldehyde;Benzaldehyde, 3-bromo-5-fluoro-4-hydroxy-
- CBNumber:
- CB22565572
- Molecular Formula:
- C7H4BrFO2
- Molecular Weight:
- 219.01
- MDL Number:
- MFCD21606586
- MOL File:
- 185345-46-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2913000090 |
3-broMo-5-fluoro-4-hydroxybenzaldehyde price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC905038 | 3-Bromo-5-fluoro-4-hydroxybenzaldehyde 95% | 185345-46-4 | 1g | $25 | 2026-06-04 | Buy |
| Apolloscientific | PC905038 | 3-Bromo-5-fluoro-4-hydroxybenzaldehyde 95% | 185345-46-4 | 5g | $113 | 2026-06-04 | Buy |
| Activate Scientific | AS40737 | 3-Bromo-5-fluoro-4-hydroxybenzaldehyde 95% | 185345-46-4 | 1g | $51 | 2026-06-04 | Buy |
| Activate Scientific | AS40737 | 3-Bromo-5-fluoro-4-hydroxybenzaldehyde 95% | 185345-46-4 | 5g | $155 | 2026-06-04 | Buy |
| Activate Scientific | AS40737 | 3-Bromo-5-fluoro-4-hydroxybenzaldehyde 95% | 185345-46-4 | 25g | $554 | 2026-06-04 | Buy |
3-broMo-5-fluoro-4-hydroxybenzaldehyde Chemical Properties, Uses, Production
Uses
3-Bromo-5-fluoro-4-hydroxybenzaldehyde can be used to prepare derivatives to treat malignant tumor, as well as, CRTH2 receptor inhibitors to treat inflammatory disorders.
Synthesis
405-05-0
185345-46-4
Synthesis of 3-bromo-5-fluoro-4-hydroxybenzaldehyde (26): 3-fluoro-4-hydroxybenzaldehyde (2 g, 14.3 mmol, 1 eq.) was dissolved in acetic acid (60 mL) and bromine (2.7 g, 17.0 mmol, 1.2 eq.) was added slowly to a solution of acetic acid (10 mL). The reaction mixture was stirred at 45°C for 26 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure and saturated saline (50 mL) was added to the residue and extracted with ethyl acetate (3 x 80 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by reversed-phase semi-preparative high-performance liquid chromatography (HPLC) to afford the target product 3-bromo-5-fluoro-4-hydroxybenzaldehyde (26) 1.5 g in 48% yield.
References
[1] Patent: WO2010/102154, 2010, A2. Location in patent: Page/Page column 56
[2] Patent: WO2011/2814, 2011, A2. Location in patent: Page/Page column 48
3-broMo-5-fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials
3-broMo-5-fluoro-4-hydroxybenzaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| SanoChem (Chengdu) Tech. Co., Ltd. | 28-87999436 02887999436 | sales@sano-chem.com | China | 3792 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6746 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 400821072 | malulu@leyan.com | China | 24933 | 58 |
