3-Fluoro-4-hydroxybenzaldehyde
- CAS No.
- 405-05-0
- Chemical Name:
- 3-Fluoro-4-hydroxybenzaldehyde
- Synonyms
- uoro-4-hydroxybenzaL;2-Fluoro-4-formylphenol;4-HYDROXY-3-FLUOROBENZALDEHYDE;3-FLUORO-4-HYDROXYBENZALDEHYDE;3-Fluoro-4-hydroxybenzaldehyde>Benzaldehyde, 3-fluoro-4-hydroxy-;3-Fluoro-4-hydroxybenzaldehyde ,98%
- CBNumber:
- CB2179108
- Molecular Formula:
- C7H5FO2
- Molecular Weight:
- 140.11
- MDL Number:
- MFCD00016626
- MOL File:
- 405-05-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 121-124°C |
|---|---|
| Boiling point | 225.6±20.0 °C(Predicted) |
| Density | 1.4710 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| pka | 6.52±0.18(Predicted) |
| color | Light yellow to Yellow to Orange |
| Sensitive | Air Sensitive |
| BRN | 3234259 |
| InChI | InChI=1S/C7H5FO2/c8-6-3-5(4-9)1-2-7(6)10/h1-4,10H |
| InChIKey | QSBHJTCAPWOIIE-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC=C(O)C(F)=C1 |
| CAS DataBase Reference | 405-05-0(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-52-41-37/38 | |||||||||
| Safety Statements | 26-36-36/37/39-27-39 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29145090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3-Fluoro-4-hydroxybenzaldehyde price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS003043 | 3-Fluoro-4-hydroxybenzaldehyde AldrichCPR | 250 mg | $77.9 | 2026-04-30 | Buy | |
| TCI Chemical | F0725 | 3-Fluoro-4-hydroxybenzaldehyde >98.0%(GC) | 405-05-0 | 1g | $67 | 2026-04-30 | Buy |
| TCI Chemical | F0725 | 3-Fluoro-4-hydroxybenzaldehyde >98.0%(GC) | 405-05-0 | 5g | $165 | 2026-04-30 | Buy |
| Usbiological | 425631 | 3-Fluoro-4-hydroxybenzaldehyde | 405-05-0 | 1g | $326 | 2026-06-03 | Buy |
| Usbiological | 425631 | 3-Fluoro-4-hydroxybenzaldehyde | 405-05-0 | 5g | $439 | 2026-06-03 | Buy |
3-Fluoro-4-hydroxybenzaldehyde Chemical Properties, Uses, Production
Uses
3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid, which is an impurity and intermediate in the preparation of Roflumilast.
Chemical Properties
White crystalline powder
Uses
3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid (C988720), which is an impurity and intermediate in the preparation of Roflumilast (R639700).
Synthesis
351-54-2
405-05-0
The general procedure for the synthesis of 3-fluoro-4-hydroxybenzaldehyde from 3-fluoro-4-methoxybenzaldehyde was as follows: 3-fluoro-4-methoxybenzaldehyde (1 g, 6.5 mmol) was mixed with boron tribromide (1 M solution in dichloromethane, 19.5 mmol) in dichloromethane, and the reaction was stirred for 24 hours under ice bath conditions. Upon completion of the reaction, an excess of anhydrous methanol was added to the reaction system, followed by removal of the solvent and the resulting trimethyl borate by distillation under reduced pressure. The residue was dissolved in methanol and again subjected to reduced pressure distillation to completely remove the residual trimethyl borate. The resulting solid residue was dissolved in ethyl acetate, the organic phase was washed with water (3 x 100 ml) and dried with anhydrous sodium sulfate. The organic solvent was removed by concentration under reduced pressure, and the crude product obtained was purified by silica gel column chromatography (eluent ratio of petroleum ether:ethyl ether=8:2) to finally obtain the pure 3-fluoro-4-hydroxybenzaldehyde. The yield was 91%; the melting point was 120-123 °C; the 1H NMR (CDCl3) data were as follows: δ 6.04 (s, exchangeable with D2O, 1H, OH); 7.16 (m, 1H, aromatic hydrogen); 7.62-7.67 (m, 2H, aromatic hydrogen); 9.86 (s, 1H, CHO). Elemental analysis results (C7H5FO2) Calculated values: C 60.01, H 3.60; measured values: C 59.93, H 3.77.
References
[1] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 112 - 127
[2] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 88-89
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 4, p. 690 - 705
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 14, p. 5032 - 5038
3-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from 3-Fluoro-4-hydroxybenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-17 | 3-Fluoro-4-hydroxybenzaldehyde
405-05-0
|
$25.00 | 1KG | 99% | 300 Tons/ year | Speranza Chemical Co., Ltd.
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2026-03-20 | 3-Fluoro-4-hydroxybenzaldehyde
405-05-0
|
$9.90 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
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2026-02-02 | 3-Fluoro-4-hydroxybenzaldehyde
405-05-0
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-Fluoro-4-hydroxybenzaldehyde
405-05-0
- $25.00
- 99%
- Speranza Chemical Co., Ltd.
-
- 3-Fluoro-4-hydroxybenzaldehyde
405-05-0
- $9.90
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Fluoro-4-hydroxybenzaldehyde
405-05-0
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
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