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3-Fluoro-4-hydroxybenzaldehyde

3-Fluoro-4-hydroxybenzaldehyde structure

CAS No.: 405-05-0

Chemical Name:: 3-Fluoro-4-hydroxybenzaldehyde

Synonyms: uoro-4-hydroxybenzaL;2-Fluoro-4-formylphenol;4-HYDROXY-3-FLUOROBENZALDEHYDE;3-FLUORO-4-HYDROXYBENZALDEHYDE;3-Fluoro-4-hydroxybenzaldehyde>Benzaldehyde, 3-fluoro-4-hydroxy-;3-Fluoro-4-hydroxybenzaldehyde ,98%

CBNumber:: CB2179108

Molecular Formula:: C7H5FO2

Molecular Weight:: 140.11

MDL Number:: MFCD00016626

MOL File:: 405-05-0.mol

Last updated:2025-07-24 18:13:52

Product description	Number	Pack Size	Price
3-Fluoro-4-hydroxybenzaldehyde Aldrich^CPR	CDS003043	250 mg	$73.1
3-Fluoro-4-hydroxybenzaldehyde >98.0%(GC)	F0725	1g	$84
3-Fluoro-4-hydroxybenzaldehyde >98.0%(GC)	F0725	5g	$206
3-Fluoro-4-hydroxybenzaldehyde	F591905	5g	$85
3-Fluoro-4-hydroxybenzaldehyde	J54168	25g	$105
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3-Fluoro-4-hydroxybenzaldehyde Properties

Melting point	121-124°C
Boiling point	225.6±20.0 °C(Predicted)
Density	1.4710 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	powder to crystal
pka	6.52±0.18(Predicted)
color	Light yellow to Yellow to Orange
Sensitive	Air Sensitive
BRN	3234259
InChI	InChI=1S/C7H5FO2/c8-6-3-5(4-9)1-2-7(6)10/h1-4,10H
InChIKey	QSBHJTCAPWOIIE-UHFFFAOYSA-N
SMILES	C(=O)C1=CC=C(O)C(F)=C1
CAS DataBase Reference	405-05-0(CAS DataBase Reference)
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38-52-41-37/38

Safety Statements

26-36-36/37/39-27-39

HazardClass

IRRITANT

HS Code

29145090

NFPA 704

	1
2		0

3-Fluoro-4-hydroxybenzaldehyde price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS003043	3-Fluoro-4-hydroxybenzaldehyde Aldrich^CPR		250 mg	$73.1	2025-07-31	Buy
TCI Chemical	F0725	3-Fluoro-4-hydroxybenzaldehyde >98.0%(GC)	405-05-0	1g	$84	2025-07-31	Buy
TCI Chemical	F0725	3-Fluoro-4-hydroxybenzaldehyde >98.0%(GC)	405-05-0	5g	$206	2025-07-31	Buy
TRC	F591905	3-Fluoro-4-hydroxybenzaldehyde	405-05-0	5g	$85	2021-12-16	Buy
AK Scientific	J54168	3-Fluoro-4-hydroxybenzaldehyde	405-05-0	25g	$105	2021-12-16	Buy

Product number	Packaging	Price	Buy
CDS003043	250 mg	$73.1	Buy
F0725	1g	$84	Buy
F0725	5g	$206	Buy
F591905	5g	$85	Buy
J54168	25g	$105	Buy

3-Fluoro-4-hydroxybenzaldehyde Chemical Properties,Uses,Production

Uses

3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid, which is an impurity and intermediate in the preparation of Roflumilast.

Chemical Properties

White crystalline powder

Uses

3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid (C988720), which is an impurity and intermediate in the preparation of Roflumilast (R639700).

Synthesis

351-54-2

405-05-0

The general procedure for the synthesis of 3-fluoro-4-hydroxybenzaldehyde from 3-fluoro-4-methoxybenzaldehyde was as follows: 3-fluoro-4-methoxybenzaldehyde (1 g, 6.5 mmol) was mixed with boron tribromide (1 M solution in dichloromethane, 19.5 mmol) in dichloromethane, and the reaction was stirred for 24 hours under ice bath conditions. Upon completion of the reaction, an excess of anhydrous methanol was added to the reaction system, followed by removal of the solvent and the resulting trimethyl borate by distillation under reduced pressure. The residue was dissolved in methanol and again subjected to reduced pressure distillation to completely remove the residual trimethyl borate. The resulting solid residue was dissolved in ethyl acetate, the organic phase was washed with water (3 x 100 ml) and dried with anhydrous sodium sulfate. The organic solvent was removed by concentration under reduced pressure, and the crude product obtained was purified by silica gel column chromatography (eluent ratio of petroleum ether:ethyl ether=8:2) to finally obtain the pure 3-fluoro-4-hydroxybenzaldehyde. The yield was 91%; the melting point was 120-123 °C; the 1H NMR (CDCl3) data were as follows: δ 6.04 (s, exchangeable with D2O, 1H, OH); 7.16 (m, 1H, aromatic hydrogen); 7.62-7.67 (m, 2H, aromatic hydrogen); 9.86 (s, 1H, CHO). Elemental analysis results (C7H5FO2) Calculated values: C 60.01, H 3.60; measured values: C 59.93, H 3.77.

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 112 - 127
[2] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 88-89
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 4, p. 690 - 705
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 14, p. 5032 - 5038

3-Fluoro-4-hydroxybenzaldehyde synthesis

Synthesis of 3-Fluoro-4-hydroxybenzaldehyde from 3-Fluoro-4-methoxybenzaldehyde

3-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

2-Fluorophenol Chloroform Sodium hydroxide 3-Fluoro-4-methoxybenzaldehyde Trifluoroacetic acid

Dichloromethane Boron tribromide

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Preparation Products

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE 3-broMo-5-fluoro-4-hydroxybenzaldehyde 3-fluoro-4-(2-hydroxyethoxy)benzaldehyde 3-Fluoro-4-hydroxy-5-nitrobenzaldehyde, 95% 3-(3-fluoro-4-hydroxyphenyl)acrylic acid

4-ETHOXY-3-FLUOROBENZALDEHYDE

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3-Fluoro-4-hydroxybenzaldehyde Suppliers

Global( 293)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12247	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58

View Lastest Price from 3-Fluoro-4-hydroxybenzaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-17	3-Fluoro-4-hydroxybenzaldehyde 405-05-0	US $25.00 / KG	1KG	99%	300 Tons/ year	Speranza Chemical Co., Ltd.
2025-10-17	3-Fluoro-4-hydroxybenzaldehyde 405-05-0	US $9.90 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-08-08	TRANS-2-HEXENAL 405-05-0	US $0.00 / KG	1KG	99%	50000KG/month	Sichuan Zhuoyu Yantang Technology Co., Ltd.

3-Fluoro-4-hydroxybenzaldehyde
405-05-0
US $25.00 / KG
99%
Speranza Chemical Co., Ltd.

3-Fluoro-4-hydroxybenzaldehyde
405-05-0
US $9.90 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

TRANS-2-HEXENAL
405-05-0
US $0.00 / KG
99%
Sichuan Zhuoyu Yantang Technology Co., Ltd.

3-Fluoro-4-hydroxybenzaldehyde Spectrum

3-Fluoro-4-hydroxybenzaldehyde(405-05-0)¹HNMR

405-05-0(3-Fluoro-4-hydroxybenzaldehyde)Related Search:

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3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER 2,3,5,6-Tetrafluoro-4-hydroxy-benzoic acid 3-Fluoro-4-methoxyacetophenone 3-Fluoro-4-hydroxybenzoic acid 3-(3-FLUORO-4-METHOXYBENZOYL)PROPIONIC ACID

3',5'-DIFLUORO-4'-HYDROXYPROPIOPHENONE 3-Fluoro-4-methoxybenzaldehyde Fluorine

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3-FLUORO-4-HYDROXYBENZALDEHYDE 4-HYDROXY-3-FLUOROBENZALDEHYDE 3-Fluoro-4-hydroxybenzaldehyde ,98% 2-Fluoro-4-formylphenol Benzaldehyde, 3-fluoro-4-hydroxy- uoro-4-hydroxybenzaL 3-Fluoro-4-hydroxybenzaldehyde> 405-05-0 405-05-8 405-05-5 Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde Fluorine series