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3,4-(Methylenedioxy)cinnamic acid

3,4-(Methylenedioxy)cinnamic acid structure

CAS No.: 2373-80-0

Chemical Name:: 3,4-(Methylenedioxy)cinnamic acid

Synonyms: AKOS B004102;AKOS AUF01566;AKOS BBS-00006476;RARECHEM BK HC S236;Piperonylideneacetic;PIPERONYL ACRYLIC ACID;3-PIPERONYLACRYLIC ACID;3,4-Methoxy cinnaMic acid;Piperonylideneacetic acid.;Acetic acid, piperonylidene-

CBNumber:: CB2257147

Molecular Formula:: C10H8O4

Molecular Weight:: 192.17

MDL Number:: MFCD00005837

MOL File:: 2373-80-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:01:49

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3,4-(Methylenedioxy)cinnamic acid Properties

Melting point	242-244 °C (dec.)(lit.)
Boiling point	248.14°C (rough estimate)
Density	1.0825 (rough estimate)
refractive index	1.4440 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	very faint turbidity in Pyridine
form	powder to crystal
pka	4.37±0.10(Predicted)
color	White to Light yellow
BRN	84599
InChI	InChI=1S/C10H8O4/c11-10(12)4-2-7-1-3-8-9(5-7)14-6-13-8/h1-5H,6H2,(H,11,12)
InChIKey	QFQYZMGOKIROEC-DUXPYHPUSA-N
SMILES	C(O)(=O)C=CC1=CC=C2OCOC2=C1
CAS DataBase Reference	2373-80-0(CAS DataBase Reference)
FDA UNII	X8H0WPJ08Y
NIST Chemistry Reference	3,4-Methylenedioxycinnamic acid(2373-80-0)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

38-36/37/38

Safety Statements

36-24/25-37-26

WGK Germany

HazardClass

IRRITANT

HS Code

29329990

Storage Class

11 - Combustible Solids

REACH Registrations

Active

NFPA 704

	0
2		0

3,4-(Methylenedioxy)cinnamic acid price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	146242	3,4-(Methylenedioxy)cinnamic acid, predominantly trans 99%	2373-80-0	5g	$65.4	2026-04-30	Buy
Sigma-Aldrich	146242	3,4-(Methylenedioxy)cinnamic acid, predominantly trans 99%	2373-80-0	25g	$256	2026-04-30	Buy
TCI Chemical	M0634	3,4-Methylenedioxycinnamic Acid >98.0%(HPLC)(T)	2373-80-0	25g	$121	2026-04-30	Buy
Biosynth	FM71196	3,4-Methylenedioxycinnamic acid	2373-80-0	0.25kg	$150	2026-06-04	Buy
Biosynth	FM71196	3,4-Methylenedioxycinnamic acid	2373-80-0	0.1kg	$150	2026-06-04	Buy

Product number	Packaging	Price	Buy
146242	5g	$65.4	Buy
146242	25g	$256	Buy
M0634	25g	$121	Buy
FM71196	0.25kg	$150	Buy
FM71196	0.1kg	$150	Buy

3,4-(Methylenedioxy)cinnamic acid Chemical Properties, Uses, Production

Chemical Properties

white to light yellow granular powder

Uses

3,4-(Methylenedioxy)cinnamic acid, predominantly trans is an inhibitor of the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase.

Definition

ChEBI: Methylenedioxycinnamic acid is a hydroxycinnamic acid.

General Description

3,4-(Methylenedioxy)cinnamic acid is an inhibitor of the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase. It undergoes electron transfer reaction with trichloromethylperoxyl radical and reaction has been studied by pulse radiolysis.

Purification Methods

Crystallise the acid from glacial AcOH, EtOH (m 247o) or aqueous EtOH (m 240-242o), and it has m 242o after sublimation. [Beilstein 19 H 278, 19 II 299, 19 III/IV 3548.]

3,4-(Methylenedioxy)cinnamic acid synthesis

Synthesis of 3,4-(Methylenedioxy)cinnamic acid from (E)-methyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate

3,4-(Methylenedioxy)cinnamic acid Preparation Products And Raw materials

Raw materials

Piperonyl aldehyde Piperidine Potassium Acetate

Preparation Products

3-(1,3-Benzodioxol-5-yl)-2-propenoyl chloride savinin 5-Hydroxy-1-indanone Ilepcimide

3,4-(Methylenedioxy)cinnamic acid Suppliers

Global Suppliers ( 212)

Supplier	Tel	Email	Country	ProdList	Advantage
NANJING DAOGE BIOPHARMA CO.,LTD.	025-58227606 18021503536	sale@daogepharm.com	China	65	58
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
NANJING DAOGE BIOPHARMA CO.,LTD.	58
Nanjing Chemlin Chemical Co., Ltd	64
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Ark Pharm, Inc.	56
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56

View Latest Price from 3,4-(Methylenedioxy)cinnamic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	3,4-(Methylenedioxy)cinnamic acid 2373-80-0	$1.00	1kg	95%-99%		Career Henan Chemical Co

3,4-(Methylenedioxy)cinnamic acid
2373-80-0
$1.00
95%-99%
Career Henan Chemical Co

3,4-(Methylenedioxy)cinnamic acid Spectrum

3,4-(Methylenedioxy)cinnamic acid(2373-80-0)¹HNMR 3,4-(Methylenedioxy)cinnamic acid(2373-80-0)IR 3,4-(Methylenedioxy)cinnamic acid(2373-80-0)FT-IR 3,4-(Methylenedioxy)cinnamic acid(2373-80-0)Raman

2373-80-0 (3,4-(Methylenedioxy)cinnamic acid) Related Search:

Methyl cinnamate Ethyl 4-methoxycinnamate Ethyl cinnamate Octyl 4-methoxycinnamate 4-Bromocinnamic acid

trans-Cinnamic acid Cinnamic acid 4-Methoxycinnamic acid Acrylic acid 2-Bromo-4,5-methylenedioxycinnamic acid

4,5-Methylenedioxy-2-nitrocinnamic acid 2-Phenyl-4-piperonylidene-2-oxazolin-5-one Ethyl 3-(1,3-benzodioxol-5-yl)-2-cyanoacrylate 3-(1,3-Benzodioxol-5-yl)-2-cyanoacrylic acid Methyl (E)-3-(1,3-benzodioxol-5-yl)-2-propenoate

Isobutyl alpha-cyano-3,4-methylenedioxycinnamate (2E)-3-(2,2-Difluoro-1,3-benzodioxol-5-yl)propenoicacid 4-Methoxyphenyl (E)-3-(6-bromo-1,3-benzodioxol-5-yl)-2-propenoate

1of4

3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid 3-(3,4-Methylene-dioxphenyl)acrylicacid 3-(3,4-Methylenedioxyphenyl)propenoic acid 3-(3,4-Methylenedioxyphenyl)propenoicacid (2E)-3-(1,3-benzodioxol-5-yl)prop-2-enoic acid 3,4-Methylenedioxybenzene-3-acrylic acid Acetic acid, piperonylidene- Cinnamic acid, 3,4-(methylenebis(oxy))- Cinnamic acid, 3,4-(methylenedioxy)- Piperonylideneacetic (E)-3-BENZO[1,3]DIOXOL-5-YL-ACRYLIC ACID 3-BENZO[1,3]DIOXOL-5-YL-ACRYLIC ACID 3-PIPERONYLACRYLIC ACID AKOS B004102 AKOS AUF01566 AKOS BBS-00006476 3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOIC ACID 3-(1,3-BENZODIOXOL-5-YL)ACRYLIC ACID 3,4-(METHYLENEDIOXY)CINNAMIC ACID 3-(3,4-METHYLENE DIOXO-PHENYL)-ACROLEIC ACID 3-(3,4-METHYLENEDIOXYPHENYL) ACRYLIC ACID (2E)-3-(1,3-BENZODIOXOL-5-YL)ACRYLIC ACID 3,4-(Methylenedioxy)cinnamic acid, predominantly trans 99% trans-3,4-(Methylenedioxy)cinnamic acid 2-Propenoic acid, 3-(1,3-benzodioxol-5-yl)- 3-(1,3-Benzodioxyl-5-yl)-2-propenoicacid 3-(1,3-Benzodioxol-5-yl)propenoic acid PIPERONYL ACRYLIC ACID RARECHEM BK HC S236 3,4-(METHYLENEDIOXY)CINNAMIC ACID, 99%, PREDOMINANTLY TRANS 3,4-(Methylenedioxy)cinnamic acid, predominantly trans, 99% Piperonylideneacetic acid. 1,3-Benzodioxole-5-acrylic acid 1,3-Benzodioxole-5-propenoic acid 3-(1,3-Benzodioxole-5-yl)propenoic acid 3,4-(Methylenebisoxy)benzeneacrylic acid 2-propenoic acid, 3-(1,3-benzodioxol-5-yl)-, (2E)- (2E)-3-(2H-1,3-benzodioxol-5-yl)prop-2-enoic acid (3,4-Methylendioxy)cinnamic acid 3-(1,3-Benzodioxol-5-yl)acrylic Acid 3-Piperonylacrylic Acid 3,4-Methoxy cinnaMic acid 3,4-MethylenedioxycinnamicAcid> 3,4-(Methylenedioxy)cinnamicaci 3,4-(Methylenedioxy)cinnamic acid USP/EP/BP 3,4-(Methylenedioxy)cinnamic acid-99% (E)-3-(1,3-benzodioxol-5-yl)prop-2-enoic acid 3',4'-Methylenedioxycinnamic acid 3,4-(Methylenedioxy)cinnamic acid, 10 mM in DMSO 3,4-(Methylenedioxy)cinnamic acid, predominantly trans 3,4-Methylenedioxycinnamic acid 97%min 3,4-(Methylenedioxy)cinnamic acid, predominantly trans 2373-80-0 C10H8O4 Organic Building Blocks Building Blocks Carboxylic Acids Carbonyl Compounds C10