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ARC Polyclonal Antibody

CAS No.
Chemical Name:
ARC Polyclonal Antibody
Synonyms
ARC Polyclonal Antibody
CBNumber:
CB22590288
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2025-08-20 16:56:12

ARC Polyclonal Antibody price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 160737 ARC Polyclonal Antibody 1ea $382 2026-04-30 Buy
Product number Packaging Price Buy
160737 1ea $382 Buy

ARC Polyclonal Antibody Chemical Properties, Uses, Production

Description

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain-containing cell death regulators included RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The mRNA for ARC is expressed primarily in skeletal muscle and cardiac tissues.

References

[1] T KOSEKI. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95 9: 5156-5160. DOI: 10.1073/pnas.95.9.5156
[2] GIORGIO GAGLIA  Galit L. Constant rate of p53 tetramerization in response to DNA damage controls the p53 response.[J]. Molecular Systems Biology, 2014, 10: 753. DOI: 10.15252/msb.20145168
[3] SHEILA JEUDY. Bcl-2 inhibits the innate immune response during early pathogenesis of murine congenital muscular dystrophy.[J]. PLoS ONE, 2011: e22369. DOI: 10.1371/journal.pone.0022369

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ARC Polyclonal Antibody