4,6-dichloro-3-nitropyridin-2-aMine
- CAS No.
- 37660-64-3
- Chemical Name:
- 4,6-dichloro-3-nitropyridin-2-aMine
- Synonyms
- 4,6-Dichloro-3-nitro-2-pyridinamine;4,6-dichloro-3-nitropyridin-2-aMine;2-Pyridinamine, 4,6-dichloro-3-nitro-;2-AMino-4,6-dichloro-3-nitro-pyridine;11. 2-Amino-3-nitro-4,6-diChloroPyridine
- CBNumber:
- CB22606095
- Molecular Formula:
- C5H3Cl2N3O2
- Molecular Weight:
- 208
- MDL Number:
- MFCD26383593
- MOL File:
- 37660-64-3.mol
- MSDS File:
- SDS
| Boiling point | 366.1±37.0 °C(Predicted) |
|---|---|
| Density | 1.723±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -2.71±0.50(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C5H3Cl2N3O2/c6-2-1-3(7)9-5(8)4(2)10(11)12/h1H,(H2,8,9) |
| InChIKey | JHRWWIQRZCVYJZ-UHFFFAOYSA-N |
| SMILES | C1(N)=NC(Cl)=CC(Cl)=C1[N+]([O-])=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4,6-dichloro-3-nitropyridin-2-aMine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 298195 | 4,6-Dichloro-3-nitropyridin-2-amine | 37660-64-3 | 1.00g | $71 | 2026-05-19 | Buy |
| Matrix Scientific | 298195 | 4,6-Dichloro-3-nitropyridin-2-amine | 37660-64-3 | 5.00g | $298 | 2026-05-19 | Buy |
| Matrix Scientific | 298195 | 4,6-Dichloro-3-nitropyridin-2-amine | 37660-64-3 | 25.00g | $1138 | 2026-05-19 | Buy |
| Synthonix | D36809 | 4,6-Dichloro-3-nitropyridin-2-amine | 37660-64-3 | 100mg | $20 | 2026-05-06 | Buy |
| Synthonix | D36809 | 4,6-Dichloro-3-nitropyridin-2-amine | 37660-64-3 | 250mg | $30 | 2026-05-06 | Buy |
4,6-dichloro-3-nitropyridin-2-aMine Chemical Properties, Uses, Production
Uses
4,6-Dichloro-3-nitropyridin-2-amine is a reagent used in the preparation of mTOR inhibitors.
Uses
4,6-Dichloro-3-nitropyridin-2-amine is a reagent used in the preparation of mTOR inhibitors.
Synthesis
116632-24-7
37660-64-3
General procedure for the synthesis of 4,6-dichloro-3-nitro-2-pyridinamine from 2-amino-4,6-dichloropyridine: 2-amino-4,6-dichloropyridine (4.48 g, 27.48 mmol) was added in batches to concentrated sulfuric acid (6 mL) and fuming nitric acid (1.2 mL) was added slowly and dropwise at 5 °C. The reaction mixture was stirred continuously for 10 h at 5 °C. After completion of the reaction, the reaction was quenched with ice water and the pH was adjusted to 7 to give 3.55 g of yellow solid 4,6-dichloro-3-nitro-2-pyridinamine washed with methanol (yield: 62.1%). Melting point: 208°C. 1H-NMR (300MHz, CDCl3), δ (ppm): 6.84 (s, 1H), 6.25 (br, 2H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3395 - 3398
[2] Patent: WO2014/128465, 2014, A1. Location in patent: Page/Page column 102
[3] Patent: WO2018/75937, 2018, A1. Location in patent: Paragraph 00317; 00318; 00588
4,6-dichloro-3-nitropyridin-2-aMine Preparation Products And Raw materials
4,6-dichloro-3-nitropyridin-2-aMine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 987 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3995 | 55 |
| ShangHai Zexin Chemical Technology Co., Ltd. | 021-60136491 15901897992 | China | 453 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd. | 19943855286 | 94644163@qq.com | China | 1934 | 56 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 87240 | 60 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
View Latest Price from 4,6-dichloro-3-nitropyridin-2-aMine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-17 | 4,6-dichloro-3-nitropyridin-2-aMine
37660-64-3
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 4,6-dichloro-3-nitropyridin-2-aMine
37660-64-3
- $7.00
- 99%
- Career Henan Chemical Co
