PF-03654746 (free base)
- CAS No.
- 935840-31-6
- Chemical Name:
- PF-03654746 (free base)
- Synonyms
- PF-03654746;PF-03654746 (free base);SXMBKHYDZOCBMT-PPUGGXLSSA-N;PF 03654746,PF-03654746,Inhibitor,PF03654746,inhibit,Histamine Receptor;Cyclobutanecarboxamide, N-ethyl-3-fluoro-3-[3-fluoro-4-(1-pyrrolidinylmethyl)phenyl]-, trans-
- CBNumber:
- CB22628237
- Molecular Formula:
- C18H24F2N2O
- Molecular Weight:
- 322.39
- MDL Number:
- MOL File:
- 935840-31-6.mol
- MSDS File:
- SDS
| Boiling point | 460.5±45.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 15.89±0.40(Predicted) |
| FDA UNII | G3QE979K1X |
PF-03654746 (free base) Chemical Properties,Uses,Production
Uses
PF-03654746 is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 reduces allergen-induced nasal symptoms, might be a novel therapeutic strategy to further explore allergic rhinitis[1]. PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].
References
[1] Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. DOI:10.1016/j.jaci.2011.11.026
[2] Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46. DOI:10.1124/jpet.110.166876
PF-03654746 (free base) Preparation Products And Raw materials
Raw materials
Preparation Products
PF-03654746 (free base) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Shanghai Shanyuan pharmaceutical technology co., LTD | 021-31761238 13167072949 | 3146446224@qq.com | China | 1377 | 55 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29545 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12000 | 58 |
View Lastest Price from PF-03654746 (free base) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-22 | PF-03654746
935840-31-6
|
US $253.00-882.00 / mg | 98.85% | 10g | TargetMol Chemicals Inc. |
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- PF-03654746
935840-31-6
- US $253.00-882.00 / mg
- 98.85%
- TargetMol Chemicals Inc.
