1,4-ditosyl-1,4-diazepane
- CAS No.
- 5769-35-7
- Chemical Name:
- 1,4-ditosyl-1,4-diazepane
- Synonyms
- Fasudil Impurity B;1,4-ditosyl-1,4-diazepane;N,N'-di-p-toluenesulfonylhomopiperazine;1H-1,4-Diazepine, hexahydro-1,4-bis[(4-methylphenyl)sulfonyl]-
- CBNumber:
- CB22642817
- Molecular Formula:
- C19H24N2O4S2
- Molecular Weight:
- 408.53
- MDL Number:
- MFCD01871709
- MOL File:
- 5769-35-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1,4-ditosyl-1,4-diazepane price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 144032 | 1,4-Ditosyl-1,4-diazepane | 5769-35-7 | 1.00g | $1814 | 2026-05-18 | Buy |
| Matrix Scientific | 144032 | 1,4-Ditosyl-1,4-diazepane | 5769-35-7 | 5.00g | $3664 | 2026-05-18 | Buy |
| Synthonix | D59426 | 1,4-Ditosyl-1,4-diazepane 95+% | 5769-35-7 | 100mg | $70 | 2026-05-06 | Buy |
| Synthonix | D59426 | 1,4-Ditosyl-1,4-diazepane 95+% | 5769-35-7 | 250mg | $100 | 2026-05-06 | Buy |
| Synthonix | D59426 | 1,4-Ditosyl-1,4-diazepane 95+% | 5769-35-7 | 1g | $180 | 2026-05-06 | Buy |
1,4-ditosyl-1,4-diazepane Chemical Properties, Uses, Production
Uses
1,4-Ditosyl-1,4-diazepane is a derivative Fasudil(F150023). Fasudil is a protein kinase A inhibitor and may be used in medicinal combinations for hepatitis treatment.
Synthesis
107-15-3
109-70-6
98-59-9
5769-35-7
General procedure: 25 kg of ethylenediamine and 80 kg of n-butanol were added to a 500 L enameled reaction tank and stirred at 25°C. The reaction system was then purified by adding 180 kg of toluene sulfonyl chloride and 90 kg of 50% sodium hydroxide solution. Subsequently, 180 kg of p-toluenesulfonyl chloride and 90 kg of 50% sodium hydroxide solution were added to the reaction system with continuous stirring for 20 minutes. The reaction mixture was heated to reflux and then 70 kg of 1-bromo-3-chloropropane and 90 kg of 50% sodium hydroxide solution were added slowly, maintaining the pH of the reaction system at 12. The reaction was continued to be heated and refluxed for 2.5 hours. After the reaction was completed, the solid product was obtained by centrifugation, and after drying, 141 kg of N,N'-bis(p-toluenesulfonyl)homopiperazine was obtained, with a yield of 88.1% and a product purity of 99.0%.
References
[1] Patent: CN104744382, 2017, B. Location in patent: Paragraph 0029; 0032; 0037; 0040; 0042; 0047; 0052
1,4-ditosyl-1,4-diazepane Preparation Products And Raw materials
Raw materials
Preparation Products
1,4-ditosyl-1,4-diazepane Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Hunan HuaTeng Pharmaceutical Co., Ltd., | 400-8592883 15367835770 | sales@huatengsci.com | China | 5869 | 58 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9883 | 50 |
| Nanjing XiZe Biotechnology CO., Ltd. | 025-66023220 15250997978 | 1511893459@qq.com | China | 4777 | 55 |
| Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd | 18210788515; 18210788515 | zhuzixin999@163.c0m | China | 4999 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| XinYao(Shenzhen) Biological Technology Co., Ltd. | 0755-89880280 | 3004662104@qq.com | China | 1826 | 58 |
