N-[2-(4-Isobutyl-phenyl)-propionyl]-methane sulfonamide
![N-[2-(4-Isobutyl-phenyl)-propionyl]-methane sulfonamide Structure](CAS/20150408/GIF/957407-64-6.gif)
- CAS No.
- 957407-64-6
- Chemical Name:
- N-[2-(4-Isobutyl-phenyl)-propionyl]-methane sulfonamide
- Synonyms
- (Rac)-Reparixin;Reparixin racemate;Reparixin Impurity 1;2-(4-isobutylphenyl)-N-(methylsulfonyl)propanamide;N-[2-(4-Isobutyl-phenyl)-propionyl]-methane sulfonamide;2-[4-(2-methylpropyl)phenyl]-N-methylsulfonylpropanamide;α-Methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide;BenzeneacetaMide,α-Methyl-4-(2-Methylpropyl)-N-(Methylsulfonyl)-
- CBNumber:
- CB22654339
- Molecular Formula:
- C14H21NO3S
- Molecular Weight:
- 283.39
- MDL Number:
- MFCD16621248
- MOL File:
- 957407-64-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
N-[2-(4-Isobutyl-phenyl)-propionyl]-methane sulfonamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0007894 | (Rac)-Reparixin 99.75% | 957407-64-6 | 2mg | $54 | 2026-06-04 | Buy |
| ChemScene | CS-0007894 | (Rac)-Reparixin 99.75% | 957407-64-6 | 5mg | $97 | 2026-06-04 | Buy |
| ChemScene | CS-0007894 | (Rac)-Reparixin 99.75% | 957407-64-6 | 10mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0007894 | (Rac)-Reparixin 99.75% | 957407-64-6 | 25mg | $303 | 2026-06-04 | Buy |
| ChemScene | CS-0007894 | (Rac)-Reparixin 99.75% | 957407-64-6 | 50mg | $487 | 2026-06-04 | Buy |
N-[2-(4-Isobutyl-phenyl)-propionyl]-methane sulfonamide Chemical Properties, Uses, Production
Uses
(Rac)-Reparixin is the isomer of Reparixin (HY-15251), and can be used as an experimental control. Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM, respectively.
References
[1] Sousa LF, et al. Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice. Clinics (Sao Paulo). 2013;68(3):391-4. DOI:10.6061/clinics/2013(03)oa17
[2] Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. DOI:10.1073/pnas.0402090101
[3] Krishnamurthy A, et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis. 2016 Apr;75(4):721-9. DOI:10.1136/annrheumdis-2015-208093
[4] Crespo J, et al. Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol. 2018 Jul 15;201(2):814-820. DOI:10.4049/jimmunol.1700755
[5] Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50(17):3984-4002. DOI:10.1021/jm061469t
[6] Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165(2):436-54. DOI:10.1111/j.1476-5381.2011.01566.x
[7] Kim HY, et al. Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34(1):120-7. DOI:10.1248/bpb.34.120
N-[2-(4-Isobutyl-phenyl)-propionyl]-methane sulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[2-(4-Isobutyl-phenyl)-propionyl]-methane sulfonamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
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| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 10000 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49299 | 58 |
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| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | Gsiyu@solarbio.com | China | 50460 | 58 |
| Shaoyuan Technology (Shanghai) Co., Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9831 | 58 |
| Hefei Mokai Pharmaceutical Technology Co., Ltd | 18130062233 | 690231469@qq.com | China | 7999 | 58 |
| Hubei YoungXin Pharmaceutical Tech Co.,Ltd. | 0714-3999001 19171453112 | 2881391661@qq.com | China | 10000 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
