Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>S-EMCA

S-EMCA

S-EMCA Structure
S-EMCA structure
CAS No.
1199796-29-6
Chemical Name:
S-EMCA
Synonyms
INT-777;S-EMCA;CS-1212;INT777,INT 777;INT-777, S-EMCA;INT-777, 10 mM in DMSO;INT-777 (Synonyms: S-EMCA);6α-Ethyl-23(S)-Methylcholic acid;6a-Ethyl-23(S)-methylcholic acid;6alpha-Ethyl-23(S)-methylcholic acid
CBNumber:
CB22667494
Molecular Formula:
C27H46O5
Molecular Weight:
450.65
MDL Number:
MFCD18837028
MOL File:
1199796-29-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-22 15:57:46
Request For Quotation

S-EMCA Properties

Melting point 150-152℃
Boiling point 602.8±55.0 °C(Predicted)
Density 1.128±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF:30.0(Max Conc. mg/mL);66.57(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);56.58(Max Conc. mM)
Ethanol:37.5(Max Conc. mg/mL);83.21(Max Conc. mM)
pka 4.80±0.21(Predicted)
form Powder
color White to yellow
FDA UNII UTD8BCW6B8

S-EMCA price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17678 INT-777 ≥95% 1199796-29-6 500μg $134 2026-04-30 Buy
Cayman Chemical 17678 INT-777 ≥95% 1199796-29-6 1mg $253 2026-04-30 Buy
Biosynth ZXB79629 6A-Ethyl-23(S)-methylcholic acid 1199796-29-6 5mg $900 2026-06-05 Buy
Biosynth ZXB79629 6A-Ethyl-23(S)-methylcholic acid 1199796-29-6 10mg $1300.1 2026-06-05 Buy
Biosynth ZXB79629 6A-Ethyl-23(S)-methylcholic acid 1199796-29-6 25mg $2119.5 2026-06-05 Buy
Product number Packaging Price Buy
17678 500μg $134 Buy
17678 1mg $253 Buy
ZXB79629 5mg $900 Buy
ZXB79629 10mg $1300.1 Buy
ZXB79629 25mg $2119.5 Buy

S-EMCA Chemical Properties, Uses, Production

Uses

INT 777 is an inhibitor of TGR5 receptor, which is a transmembrane G protein-coupled receptor expressed in brown adipose tissue and muscle and activated by bile acid.

in vivo

INT-777 (1 μM/min/kg, p.o.) has a potent choleretic effect, prevents carboxyl CoA activation and subsequent conjugation, thereby favoring its chole-hepatic shunt pathway with a ductular absorption and a potent choleretic effect in HF-fed TGR5-Tg male mice[1]. INT-777 (30 mg/kg/day, p.o.) increases energy expenditure and reduces hepatic steatosis and obesity upon high-fat feeding in TGR5-Tg mice[2].

S-EMCA synthesis

1227639-47-5
74-88-4
1199796-29-6
Synthesis of S-EMCA from Cholan-24-oic acid, 6-ethyl-3,7,12-tris(methoxymethoxy)-, methyl ester, (3α,5β,6α,7α,12α)- and Iodomethane

S-EMCA Preparation Products And Raw materials

Raw materials

Cholan-24-oic acid, 6-ethyl-3,7,12-tris(methoxymethoxy)-, methyl ester, (3α,5β,6α,7α,12α)- INT-777 (R-enantiomer) Iodomethane

Preparation Products

S-EMCA Suppliers

Global Suppliers ( 75)
Supplier Tel Email Country ProdList Advantage
Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd 19066311943 815989315@qq.com China 925 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3853 58
Supplier Advantage
Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd 58
BOC Sciences 65
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
LETOPHARM LIMITED 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
Guangzhou QiYun Biotechnology Co., Ltd. 58

View Latest Price from S-EMCA manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
INT-777 pictures 2026-07-21 INT-777
1199796-29-6
 $139.00-496.00 99.38% 10g TargetMol Chemicals Inc.
INT-777 pictures 2026-07-21 INT-777
1199796-29-6
 $139.00-496.00 99.38% 10g TargetMol Chemicals Inc.
  • INT-777 pictures
  • INT-777
    1199796-29-6
  • $139.00-496.00
  • 99.38%
  • TargetMol Chemicals Inc.
  • INT-777 pictures
  • INT-777
    1199796-29-6
  • $139.00-496.00
  • 99.38%
  • TargetMol Chemicals Inc.

S-EMCA Spectrum

S-EMCA(1199796-29-6)1HNMR

1199796-29-6 (S-EMCA) Related Search:

3-Hydroxy-bicyclo[3.1.0]hexane-6-carboxylic acid 1-Cyclopentylcyclohexane-1-carboxylic acid (4R)-4-[(3S,5S,7S,8S,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid Bicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, (endo,endo)- HETLZOWCLHWFER-UHFFFAOYSA-N
octahydro-1H-indene-3a-carboxylic acid

1of2

6α-Ethyl-23(S)-Methylcholic acid S-EMCA 6alpha-Ethyl-23(S)-methylcholic acid 6a-Ethyl-23(S)-methylcholic acid CS-1212 INT-777, S-EMCA Cholane-23-carboxylic acid, 6-ethyl-3,7,12-trihydroxy-, (3α,5β,6α,7α,12α,23S)- INT777,INT 777 (2S,4R)-4-((3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-Ethyl-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylpentanoic acid (2S,4R)-4-[(1R,3aS,3bR,4R,5R,5aS,7R,9aS,9bS,11S,11aR)-5-ethyl-4,7,11-trihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2-methylpentanoic acid Acetylcysteine Impurity 49(D-Cysteine) Obeticholic Acid Impurity 49(S-EMCA) INT-777, 10 mM in DMSO INT-777 (Synonyms: S-EMCA) INT-777 1199796-29-6