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Pymetrozine

Pymetrozine Structure
Pymetrozine structure
CAS No.
123312-89-0
Chemical Name:
Pymetrozine
Synonyms
PYMETROZIN;PYMETHROZINE;6-Methyl-4-((pyridin-3-ylMethylene)aMino)-4,5-dihydro-1,2,4-triazin-3(2H)-one;CHESS;PLENUM;A 9364A;Fulfill;Endeavor;Hsdb 7054;pyrhexone
CBNumber:
CB2267731
Molecular Formula:
C10H11N5O
Molecular Weight:
217.23
MDL Number:
MFCD01632346
MOL File:
123312-89-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-31 15:25:14
Product description Number Pack Size Price
Pymetrozin PESTANAL?, analytical standard 46119 250mg $116
Pymetrozine P2107 1G $92
Pymetrozine P2107 5G $276
Pymetrozine FP27265 5g $900
Pymetrozine FP27265 2g $900
More product size
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Pymetrozine Properties

Melting point 234.4°
Density 1.36g/cm3 (20～25℃）
vapor pressure 0Pa at 25.03℃
Flash point >230 °C
storage temp. 0-6°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 12.90±0.40(Predicted)
color White to Light Beige
BRN 7814151
Henry's Law Constant 3.3×105 mol/(m3Pa) at 25℃, HSDB (2015)
Stability Hygroscopic
Major Application agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care
Cosmetics Ingredients Functions SKIN CONDITIONING
InChI 1S/C10H11N5O/c1-8-7-15(10(16)14-13-8)12-6-9-3-2-4-11-5-9/h2-6H,7H2,1H3,(H,14,16)/b12-6+
InChIKey QHMTXANCGGJZRX-WUXMJOGZSA-N
SMILES CC1=NNC(=O)N(C1)\N=C\c2cccnc2
LogP -0.18 at 25℃ and pH7.1
Surface tension 69.4-72.3mN/m at 10g/L and 20℃
Dissociation constant 0.19-4.07 at 20℃
CAS DataBase Reference 123312-89-0(CAS DataBase Reference)
EWG's Food Scores 2
FDA UNII F0G3V7874J
Proposition 65 List Pymetrozine
EPA Substance Registry System Pymetrozine (123312-89-0)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)Environment (GHS09)
GHS08,GHS09
Signal word  Warning
Hazard statements  H351-H361fd-H410
Precautionary statements  P202-P273-P280-P308+P313-P391-P405
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  Xn
Risk Statements  40-52/53-R52/53-R40
Safety Statements  36/37-61-S61-S36/37
WGK Germany  2
RTECS  XZ3018620
HS Code  29336990
Storage Class 13 - Non Combustible Solids
Hazard Classifications Aquatic Acute 1
Aquatic Chronic 1
Carc. 2
Repr. 2
Hazardous Substances Data 123312-89-0(Hazardous Substances Data)
Toxicity LD50 orally in rats: 5820 mg/kg (Flückiger)
REACH Registrations Active

Pymetrozine price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46119 Pymetrozin PESTANAL?, analytical standard 123312-89-0 250mg $116 2026-04-30 Buy
TCI Chemical P2107 Pymetrozine 123312-89-0 1G $92 2026-04-30 Buy
TCI Chemical P2107 Pymetrozine 123312-89-0 5G $276 2026-04-30 Buy
Biosynth FP27265 Pymetrozine 123312-89-0 5g $900 2026-06-04 Buy
Biosynth FP27265 Pymetrozine 123312-89-0 2g $900 2026-06-04 Buy
Product number Packaging Price Buy
46119 250mg $116 Buy
P2107 1G $92 Buy
P2107 5G $276 Buy
FP27265 5g $900 Buy
FP27265 2g $900 Buy

Pymetrozine Chemical Properties,Uses,Production

Descriptioin

Pymetrozine is a new neuroactive insecticide. It has a remarkable selectivity for sucking insect pests, such as aphids, whiteflies, and plant hoppers, due to its systemic action. Pymetrozine is the only representative of the pyridine azomethines, a new class of insecticides. Pymetrozine has been determined to be of low acute toxicity to humans, birds, aquatic organisms, mammals, and bees. It is also not mutagenic.

Reference

[1] J. Ausborn, H. Wolf, W. Mader, H. Kayser, The insecticide pymetrozine selectively against affects chordotonal mechanoreceptors, Journal of Experimental Biology, 2005, vol. 208, pp. 4451-4466.
[2] D. Fuog, S. J. Fergusson, C. Flückiger, Pymetrozine: A Novel Insecticide Affecting Aphids and Whiteflies, Insecticides with Novel Modes of Action, 1998, ISBN 978-3-642-08314-3
[3] Yu, Jixin et al. “Acute Toxicity of an Emerging Insecticide Pymetrozine to Procambarus clarkii Associated with Rice-Crayfish Culture (RCIS).” International journal of environmental research and public health vol. 15,5 984. 14 May. 2018, doi:10.3390/ijerph15050984

Uses

Pymetrozine is a pyridine azomethine antifeedant. Pymetrozine is used as insecticide.

Production Methods

Pymetrozine is commercially produced via a multi-step process starting from nicotinic acid, which is converted to 3-pyridinecarboxaldehyde through reduction (e.g., via Rosenmund or DIBAL-H) or from 3-picoline via oxidation and selective reduction. This aldehyde undergoes condensation with hydrazine hydrate in ethanol to form the hydrazone, which is then cyclised with triazine precursor 3-amino-1,2,4-triazine under acidic conditions to construct the 1,2,4-triazolo[1,5-a]pyridine core. Final N-methylation using dimethyl sulphate or methyl iodide with potassium carbonate in DMF yields pymetrozine.

Definition

ChEBI: A member of the class of 1,2,4-triazines that is 4,5-dihydro-1,2,4-triazin-3(2H)-one substituted by a methyl group at position 6 and a (pyridin-3-ylmethylidene)amino group at position 4.

Mode of action

Pymetrozine, 6-methyl-4-[(E)-(pyridin-3-ylmethylene) amino]-4,5-dihydro-2H-[1-3]-triazin-3 one, is a pyridine azomethine compound, which represents an emerging insecticide for plant-sucking insects, such as aphids, whiteflies and plant hoppers. In addition, pymetrozine has been reported to have effects on neuro regulation or nerve-muscle interaction in sucking insects, thus preventing the insertion of their style into the plant tissue. It has been widely applied on rice and other crops in China as a substitute for organophosphorus pesticides since approximately 2006 and is rated as a Class 1 pesticide (i.e., harmless according to the International Organization for Biological and Integrated Control Scale). Pymetrozine affects the behaviour of homopterous insects and causes them to stop feeding, eventually leading to their death[3].

Pesticide Type

Insecticide

Pymetrozine synthesis

500-22-1
123313-07-5
123312-89-0
Synthesis of Pymetrozine from 3-Pyridinecarboxaldehyde and 1,2,4-Triazin-3(2H)-one, 4-amino-4,5-dihydro-6-methyl-

Pymetrozine Preparation Products And Raw materials

Raw materials

1,2,4-Triazin-3(2H)-one, 4-amino-4,5-dihydro-6-methyl-

Preparation Products

Pymetrozine Suppliers

Global( 299)Suppliers
Supplier Tel Email Country ProdList Advantage
NANJING ACE CHEMICAL CO.,LTD 		18268053070 e.wen@ace-chemical.com China 8 58
Shijiazhuang Tongyang Import and Export Co., LTD
admin@sjztongyang.com China 971 58
AS WATER CO., LTD.
+86-18994963526 1346073549@qq.com United Kingdom 176 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8737 58
Hebei Yanxi Chemical Co., Ltd. 		+86-17531190177 faithe@yan-xi.com China 5838 58
Qingdao Trust Agri Chemical Co.,Ltd 		+86-008615963231493 +86-008613573296305 trustagri@hotmail.com China 298 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-17732866630 mina@chuanghaibio.com China 18114 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
Shanxi Naipu Import and Export Co.,Ltd 		+86-13734021967 13734021967 kaia@neputrading.com China 991 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Supplier Advantage
NANJING ACE CHEMICAL CO.,LTD 		58
Shijiazhuang Tongyang Import and Export Co., LTD
58
AS WATER CO., LTD.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Qingdao Trust Agri Chemical Co.,Ltd 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanxi Naipu Import and Export Co.,Ltd 		58
career henan chemical co 		58

View Lastest Price from Pymetrozine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
pymetrozine pictures 2026-07-14 pymetrozine
123312-89-0
 10kg 50% 200 Qingdao Trust Agri Chemical Co.,Ltd
Pymetrozine pictures 2026-06-02 Pymetrozine
123312-89-0
 $37.00 99.56% 10g TargetMol Chemicals Inc.
Pymetrozine pictures 2026-03-26 Pymetrozine
123312-89-0
 1KG 98% 50 TONS NANJING ACE CHEMICAL CO.,LTD
  • pymetrozine pictures
  • pymetrozine
    123312-89-0
  • $0.00
  • 50%
  • Qingdao Trust Agri Chemical Co.,Ltd
  • Pymetrozine pictures
  • Pymetrozine
    123312-89-0
  • $37.00
  • 99.56%
  • TargetMol Chemicals Inc.
  • Pymetrozine pictures
  • Pymetrozine
    123312-89-0
  • $0.00
  • 98%
  • NANJING ACE CHEMICAL CO.,LTD

Pymetrozine Spectrum

Pymetrozine(123312-89-0)1HNMR

123312-89-0(Pymetrozine)Related Search:

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Buprofezin DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Sulfachoropyrazine sodium Methyl salicylate METSULFURON METHYL
Methyl acetate 2-Aminopyridine 4-Dimethylaminopyridine Kresoxim-methyl Metribuzin
Thiophanate-methyl Methyl Methyl bromide

1of4

Hsdb 7054 6-Methyl-4-((pyridin-3-ylMethylene)aMino)-4,5-dihydro-1,2,4-triazin-3(2H)-one (E)-4,5-dihydro-6-Methyl-4-[(3-pyridinylMethylene)aMino]-1,2,4-triazin-3(2H)-one 4,5-Dihydro-6-Methyl-4-[(E)-(3-pyridinylMethylene)aMino]-1,2,4-triazin-3(2H)-one A 9364A (E)-6-Methyl-4-((pyridin-3-ylMethylene)aMino)-4,5-dihydro-1,2,4-triazin-3(2H)-one Pymetrozine 0 Pymetrozin Solution, 100ppm CHESS (e)-4,5-fihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2h)-one PLENUM PYMETROZINE pymetrozine (ISO) (E)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-1,2,4-triazin-3(2H)-one 1,2,4-Triazin-3(2H)-one, 4,5-dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-, (E)- Cga 215944 Einecs annex I index 613-202-00-4 Endeavor Fulfill 1,2,4-Triazin-3(2H)-one, 4,5-dihydro-6-methyl-4-(E)-(3-pyridinylmethylene)amino- pymetrozine (bsi, pa e-iso) (E)-4,5-Dihydro-6-methyl-4(3-pyridylmethyleneamino)-1,2,4-triazin-3(2H)-one PYMETROZIN PESTANAL, 250 MG 6-Methyl-4-(pyridin-3-ylmethylideneamino)-2,5-dihydro-1,2,4-triazin-3-one Agkistrodon Halys Antivenin-1109 Venom of Agkistrodon Pallas Viper venom 6-methyl-4-[(E)-3-pyridinylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one 100 μg/mL in AcCN Pymetrozine Standard Pyrazole ketone of aphid pyrhexone Pymetrozin Solution in Methanol Pymetrozine TC L16587000MEPymetrozinE10μg/mLin Methanol Pymetrozine 10.0 μg/ml Acetonitrile Pymetrozine in Methanol pymetrozine (ISO) Pymetrozine, 10 mM in DMSO CAS:123312-89-0 Pymetrozine 10 μg/mL in Methanol 50%Pymetrozine WDG 60%Pymetrozine WDG 70%Pymetrozine WDG 25%Pymetrozine EV 50%Pymetrozine WP 25%Pymetrozine WP PYMETROZIN PYMETHROZINE 123312-89-0 23312-89-0 C10H11N5O C10H11N50 Alpha sort N-PPesticides&Metabolites OthersAlphabetic P Pesticides Pesticides&Metabolites