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ChemicalBook >> CAS DataBase List >>2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2)

2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2)

2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) Structure
2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) structure
CAS No.
912444-01-0
Chemical Name:
2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2)
Synonyms
PARP-2/1-IN-2;2-[(2S)-2-methylpyrrolidin-2-yl]-3H-benzimidazole-4-carboxamide;1H-Benzimidazole-7-carboxamide, 2-[(2S)-2-methyl-2-pyrrolidinyl]-;2- (2S)-2-Methylpyrrolidin-2-yl -1H-benimidazole-4- carboxamide hydrochloride (1;(S)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride;2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2)
CBNumber:
CB22684080
Molecular Formula:
C13H16N4O
Molecular Weight:
244.29
MDL Number:
MFCD26954827
MOL File:
912444-01-0.mol
MSDS File:
SDS
Last updated:2026-05-11 16:31:51
Request For Quotation

2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0025512 PARP-2/1-IN-2 ≥98% 912444-01-0 100mg $833 2026-06-04 Buy
aablocks AA00H122 (S)-2-(2-Methylpyrrolidin-2-yl)-1h-benimidazole-4-carboxamide dihydrochloride 95% 912444-01-0 1g $4267 2026-05-28 Buy
ACHEMBLOCK X188860 (S)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide 95% 912444-01-0 25MG $445 2026-05-27 Buy
ACHEMBLOCK X188860 (S)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide 95% 912444-01-0 100MG $840 2026-05-27 Buy
ACHEMBLOCK X188860 (S)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide 95% 912444-01-0 1G $5065 2026-05-27 Buy
Product number Packaging Price Buy
CS-0025512 100mg $833 Buy
AA00H122 1g $4267 Buy
X188860 25MG $445 Buy
X188860 100MG $840 Buy
X188860 1G $5065 Buy

2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) Chemical Properties, Uses, Production

Uses

PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity[1].

in vivo

PARP-2/1-IN-2 (Compound 4a) (25 or 50 mg/kg; i.p.) attenuates pain in Cisplatin (HY-17394) and Oxaliplatin (HY-17371)-induced neuropathy in mice[1].

Animal Model:Male C57BL6J mice, Cisplatin (HY-17394) and Oxaliplatin (HY-17371)-induced painful neuropathy models[1]
Dosage:25 mg/kg or 50 mg/kg
Administration:Intraperitoneal injection, two days prior to treatment with Cisplatin or oxaliplatin, with administration continuing by i.p. injection along with the Cisplatin or oxaliplatin regimen (5 days, followed by 5 days of rest, for two weekly cycles)
Result:Does not attenuate Cisplatin and Oxaliplatin-induced body weight loss. Does not Affect the decline in exploratory behavior associated with Cisplatin and Oxaliplatin Treatment. Attenuates mechanical allodynia in Cisplatin and Oxaliplatin-induced neuropathy. Attenuates thermal hyperalgesia in Cisplatin-induced neuropathy. Attenuates cold hyperalgesia associated with Oxaliplatin-induced neuropathy.

IC 50

PARP2: 2 nM (Ki); PARP1: 5 nM (Ki)

References

[1] Ta LE, et al. A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy. PLoS One. 2013;8(1):e54161. DOI:10.1371/journal.pone.0054161

2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) Preparation Products And Raw materials

Raw materials

Preparation Products

2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) Suppliers

Global Suppliers ( 8)
Supplier Tel Email Country ProdList Advantage
Nantong MYBio-pharm. Co., Ltd. 0513-85921823 18662920231 sales@ntminyanmedical.com China 4561 58
ShangHai Wisacheam Pharmaceutical Co., Ltd. 13817485796 tim@wisacheampharm.com China 3698 58
Shanghai zhigan biotechnology co., LTD zhiqianbio@126.com China 19765 58
Nantong puyue biomedical Co., Ltd 0513-0513-0513-89158300 18014392889 sales@puyerbiopharma.com China 4956 58
JW & Y Pharmlab Co., Ltd. 021-64340559 13651849907 xinyu_shi@jwypharmlab.com.cn China 9898 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 13761987713; 13761987713 hxzheng@sunwaypharm.cn China 9905 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Nantong MYBio-pharm. Co., Ltd. 58
ShangHai Wisacheam Pharmaceutical Co., Ltd. 58
Shanghai zhigan biotechnology co., LTD 58
Nantong puyue biomedical Co., Ltd 58
JW & Y Pharmlab Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from 2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PARP-2/1-IN-2 pictures 2026-05-11 PARP-2/1-IN-2
912444-01-0
 10g TargetMol Chemicals Inc.

912444-01-0 (2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2)) Related Search:

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2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) 2- (2S)-2-Methylpyrrolidin-2-yl -1H-benimidazole-4- carboxamide hydrochloride (1 1H-Benzimidazole-7-carboxamide, 2-[(2S)-2-methyl-2-pyrrolidinyl]- 2-[(2S)-2-methylpyrrolidin-2-yl]-3H-benzimidazole-4-carboxamide PARP-2/1-IN-2 (S)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride 912444-01-0