4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
- CAS No.
- 906673-45-8
- Chemical Name:
- 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
- Synonyms
- Crisaborole-003;Crisaborole Impurity 31;Crisaborole Impurity 55;Crisaborole Intermediate 1;4-(4-bromo-3-(hydroxymethyl;2-bromo-5-(4-cyanophenoxy)benzyl alcohol;2-Bromo-5-(4-cyanophenoxyl)benzyl alcohol;4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile;4,4'-Dibromo-3-(hydroxymethyl)phenoxy]benzaldehyde;Benzonitrile, 4-[4-bromo-3-(hydroxymethyl)phenoxy]-
- CBNumber:
- CB22716062
- Molecular Formula:
- C14H10BrNO2
- Molecular Weight:
- 304.14
- MDL Number:
- MFCD12165918
- MOL File:
- 906673-45-8.mol
- MSDS File:
- SDS
| Boiling point | 447.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.57±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 13.96±0.10(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C14H10BrNO2/c15-14-6-5-13(7-11(14)9-17)18-12-3-1-10(8-16)2-4-12/h1-7,17H,9H2 |
| InChIKey | DAMOSKSUIVLOJT-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(OC2=CC=C(Br)C(CO)=C2)C=C1 |
| FDA UNII | SJ3Z4JSE6C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | GLB67345 | 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile | 906673-45-8 | 500mg | $900 | 2026-06-04 | Buy |
| Biosynth | GLB67345 | 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile | 906673-45-8 | 250mg | $900 | 2026-06-04 | Buy |
| Biosynth | GLB67345 | 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile | 906673-45-8 | 2000mg | $900 | 2026-06-04 | Buy |
| Biosynth | GLB67345 | 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile | 906673-45-8 | 100mg | $900 | 2026-06-04 | Buy |
| Biosynth | GLB67345 | 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile | 906673-45-8 | 1000mg | $900 | 2026-06-04 | Buy |
4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile Chemical Properties, Uses, Production
Uses
4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile is a useful research chemical.
Chemical Properties
Class white powder
Synthesis
906673-54-9
906673-45-8
The general procedure for the synthesis of 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile from 4-(4-bromo-3-formylphenoxy)benzonitrile was as follows: 100 g of 4-(4-bromo-3-formylphenoxy)benzonitrile (VI) was dissolved in 500 mL of methanol at 25-30 °C, and subsequently cooled to 10-15 °C. While maintaining 10-15 °C, 6.2 g of sodium borohydride was slowly added for 60-90 min. After the addition was completed, the temperature of the reaction system was slowly increased to 15-20°C. Upon completion of the reaction, 1000 mL of water was added to the reaction mixture and stirred at 25-30 °C for 1 hour. The resulting solid product was collected by vacuum filtration, washed with water and dried under vacuum at not more than 55 °C to obtain 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile (V). Yield: 99.0%; purity: 99.02%.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 8, p. 2129 - 2132
[2] Patent: WO2018/207216, 2018, A1. Location in patent: Page/Page column 10
[3] Patent: CN108659024, 2018, A. Location in patent: Paragraph 0038-0039
[4] Patent: WO2018/115362, 2018, A1. Location in patent: Paragraph 0121
[5] Patent: US2007/293457, 2007, A1. Location in patent: Page/Page column 39-40
4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Welltzpharm Inc. | 028-028-85182370 | info@welltzpharm.com | China | 40 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 18080455027 | info@aktin.com | China | 2069 | 58 |
| Hangzhou Chemtrue Bio-Tech Co.,Ltd. | 19967494293 | sales@chemtrue-bio.com | China | 303 | 58 |
| Nanjing Lift Pharmaceutical Technology Co., Ltd. | 18951933883 | leo.feng@liftpharm.com | China | 312 | 58 |
| Shanghai Binma Technology Co., Ltd. | 15262241608 | yzxiajie@163.com | China | 861 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Jinan Chenghui Shuangda biological Co., LTD | 053158897070 15550412551 | market@jnchsd.com | China | 224 | 62 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-4000505016 13380397412 | 3001272453@qq.com | China | 5000 | 50 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
View Latest Price from 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
906673-45-8
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
906673-45-8
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-12-25 | 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
906673-45-8
|
1kg | 0.99 | 800kg | Wuhan Biocar Pharmacy CO.,Ltd. |
-
- 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
906673-45-8
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
906673-45-8
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
906673-45-8
- 0.99
- Wuhan Biocar Pharmacy CO.,Ltd.
