7-Amino-1,8-naphthyridin-2(8H)-one
- CAS No.
- 1931-44-8
- Chemical Name:
- 7-Amino-1,8-naphthyridin-2(8H)-one
- Synonyms
- 7-AMINO-1,8-NAPHTHYRIDIN-2-OL;SURI-002;2-AMino-1,8-naphthyridin-7-ol;7-AMino-1,8-naphthyridin-2-one;7-Amino-1,8-naphthyridine-2-ol;7-Amino-8H-1,8-naphthyridin-2-one;7-Amino-1H-[1,8]naphthyridin-2-one;7-amino-1,8-naphthyridin-2(1H)-one;7-Amino-1,8-naphthyridin-2(8H)-one;2-AMINO-7-HYDROXY-1,8-NAPHTHYRIDINE
- CBNumber:
- CB2272496
- Molecular Formula:
- C8H7N3O
- Molecular Weight:
- 161.16
- MDL Number:
- MFCD08234797
- MOL File:
- 1931-44-8.mol
- MSDS File:
- SDS
| Melting point | >335°C (dec.) |
|---|---|
| Boiling point | 415.6±38.0 °C(Predicted) |
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Methanol (Slightly, Heated) |
| form | Solid |
| pka | 3.39±0.20(Predicted) |
| color | Dark Yellow to Yellow-Brown |
| InChI | InChI=1S/C8H7N3O/c9-6-3-1-5-2-4-7(12)11-8(5)10-6/h1-4H,(H3,9,10,11,12) |
| InChIKey | NSPQTGOJGZXAJM-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC=C(N)N=2)C=CC1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H335-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
7-Amino-1,8-naphthyridin-2(8H)-one price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-A611635-5G | 2-Amino-7-hydroxy-1,8-naphthridine | 1931-44-8 | 5g | $810 | 2026-06-03 | Buy |
| AstaTech | 31042 | 7-AMINO-1H-[1,8]NAPHTHYRIDIN-2-ONE 97% | 1931-44-8 | 1G | $68 | 2026-04-30 | Buy |
| AstaTech | 31042 | 7-AMINO-1H-[1,8]NAPHTHYRIDIN-2-ONE 97% | 1931-44-8 | 5G | $205 | 2026-04-30 | Buy |
| Matrix Scientific | 202484 | 7-Amino-8H-1,8-naphthyridin-2-one | 1931-44-8 | 1.00g | $568 | 2026-05-18 | Buy |
| Synthonix | A48399 | 7-Amino-1,8-naphthyridin-2(8H)-one 97% | 1931-44-8 | 100mg | $45 | 2026-05-06 | Buy |
7-Amino-1,8-naphthyridin-2(8H)-one Chemical Properties, Uses, Production
Uses
2-Amino-7-hydroxy-1,8-naphthidine is used as a research compound and in organic synthesis, etc.
Chemical Properties
Yellow-Brown Solid
Synthesis
141-86-6
617-48-1
1931-44-8
2,6-diaminopyridine (20 g, 0.18 mol) and DL-malic acid (27 g, 0.2 mol) were used as raw materials in a 500 mL three-necked round-bottomed flask equipped with a dosing funnel, thermometer and mechanical stirrer. The mixture was cooled in an ice-water bath, and concentrated sulfuric acid (100 mL) was added slowly dropwise, with the rate of dropwise acceleration controlled to keep the reaction temperature from exceeding 45 °C. Subsequently, the addition funnel was replaced with a reflux condenser and the reaction mixture was heated to 110°C and maintained for 3 hours. Upon completion of the reaction, the solution was transferred to a 1 L beaker, cooled to 0 °C via an ice-water bath, and adjusted to pH=8 by slowly adding aqueous NH4OH (300 mL).The crude product was collected by vacuum filtration and the filter cake was washed with 2 L of water. The solid product was ground with a 1:9 (v:v) water:methanol mixture and collected again by vacuum filtration to afford 7-amino-2-hydroxy-1,8-diazanaphthalene as a tan powder in 25 g (86% yield). The product was structurally confirmed by 1H NMR (500 MHz, DMSO-d6) and 13C NMR (126 MHz, DMSO-d6) as well as mass spectrometry (ESI, CH3OH).
References
[1] Journal of Organic Chemistry, 1981, vol. 46, # 5, p. 833 - 839
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 13, p. 2578 - 2589
[3] Organic and Biomolecular Chemistry, 2012, vol. 10, # 25, p. 4899 - 4906
[4] Organic and Biomolecular Chemistry, 2012, vol. 10, # 1, p. 90 - 95
[5] Organic and Biomolecular Chemistry, 2014, vol. 12, # 33, p. 6500 - 6506
7-Amino-1,8-naphthyridin-2(8H)-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Record Tech (Shanghai) Co., LTD | 13761627472 | 183009664@qq.com | China | 660 | 62 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9954 | 58 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4975 | 55 |
| Nanjing River Chemical Co., Ltd. | 13951936332 18305166317 | info@serpharm.com | China | 493 | 55 |
| Shanghai Synchem Technology Co., Ltd. | 021-64502386 18017349250 | shsynchem@gmail.com | China | 295 | 60 |
1931-44-8 (7-Amino-1,8-naphthyridin-2(8H)-one) Related Search:
1of3
