3-TrifluoroMethoxy-pyridin-4-ylaMine
- CAS No.
- 827586-90-3
- Chemical Name:
- 3-TrifluoroMethoxy-pyridin-4-ylaMine
- Synonyms
- 3-(trifluoromethoxy)-4-Pyridinamine;4-amino-3-(trifluoromethoxy)pyridine;3-TrifluoroMethoxy-pyridin-4-ylaMine;4-Pyridinamine, 3-(trifluoromethoxy)-
- CBNumber:
- CB22725583
- Molecular Formula:
- C6H5F3N2O
- Molecular Weight:
- 178.11
- MDL Number:
- MFCD19690275
- MOL File:
- 827586-90-3.mol
3-TrifluoroMethoxy-pyridin-4-ylaMine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA008IPI | 3-(Trifluoromethoxy)pyridin-4-amine 97% | 827586-90-3 | 50mg | $175 | 2026-05-28 | Buy |
| aablocks | AA008IPI | 3-(Trifluoromethoxy)pyridin-4-amine 97% | 827586-90-3 | 100mg | $285 | 2026-05-28 | Buy |
| aablocks | AA008IPI | 3-(Trifluoromethoxy)pyridin-4-amine 97% | 827586-90-3 | 250mg | $523 | 2026-05-28 | Buy |
| aablocks | AA008IPI | 3-(Trifluoromethoxy)pyridin-4-amine 97% | 827586-90-3 | 1g | $1487 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD242950 | 3-(Trifluoromethoxy)pyridin-4-amine 95% | 827586-90-3 | 100MG | $440 | 2026-05-27 | Buy |
3-TrifluoroMethoxy-pyridin-4-ylaMine Chemical Properties, Uses, Production
Synthesis
1221171-79-4
827586-90-3
General procedure for the synthesis of 3-(trifluoromethoxy)pyridin-4-amine from 2-chloro-3-(trifluoromethoxy)pyridin-4-amine: palladium (10% activated charcoal, 470 mg) was added to a 4-amino-2-chloro-3-trifluoromethoxypyridine (20,1.5 g, 7.0 mmol) and ammonium formate (880 mg, 14.0 mmol, 2 eq.) at 25 °C in a in a solution of methanol (12 mL) was stirred. The reaction mixture was stirred at 55 °C for 16 h, followed by filtration and evaporation of the solvent. The residue was partitioned between ethyl acetate (2 x 20 mL) and water (30 mL). The organic layers were combined, dried over sodium sulfate and evaporated. Purification of the crude yellow oil by vacuum distillation afforded 4-amino-3-trifluoromethoxypyridine as a colorless oil (21,1.0 g, 5.6 mmol, 80% yield); boiling point 110-114 °C/14 mbar.1H NMR (CDCl3, 300 MHz): δ=8.19 (s,1H), 8.05 (d,J=5.5 Hz,1H). 6.59 (d,J=5.5Hz,1H), 4.41 (bs,2H).19F NMR (CDCl3,282MHz): δ=-58.7.13C NMR (CD3OD,75MHz): δ=150.8,148.5,143.5,132.9,120.8 (q,J=259Hz),110.4. Elemental analysis (C6H5F3N2O, molecular weight 178): calculated value C 40.46%, H 2.83%, N 15.73%; measured value C 40.28%, H 2.74%, N 15.94%.
References
[1] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 33-34
[2] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066
3-TrifluoroMethoxy-pyridin-4-ylaMine Preparation Products And Raw materials
Raw materials
Preparation Products
3-TrifluoroMethoxy-pyridin-4-ylaMine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| BioPharmaMatrix,Inc. | 0510-86010668 13395169561; | sales@biopharmamatrix.com | China | 4982 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6736 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 10000 | 58 |
| Shandong utilizing biological technology co., LTD | 18669728830 15966937598 | 3407650895@qq.com | China | 5166 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54996 | 58 |
| Xi'an Zhenghao Biotechnology Co., Ltd | 19829389091 | 399787610@qq.com | China | 2504 | 58 |
