FLLL31
- CAS No.
- 52328-97-9
- Chemical Name:
- FLLL31
- Synonyms
- Tetramethylcurcumin;FLLL31;FLLL31 >=98% (HPLC);FLLL31;FLLL-31;FLLL 31;Tetramethylcurcumin（FLLL31）;Tetramethylcurcumin, 10 mM in DMSO;(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione;(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)-
- CBNumber:
- CB22731058
- Molecular Formula:
- C25H28O6
- Molecular Weight:
- 424.49
- MDL Number:
- MFCD19443859
- MOL File:
- 52328-97-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 69-71 °C |
|---|---|
| Boiling point | 594.5±50.0 °C(Predicted) |
| Density | 1.140±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | yellow |
| InChI | 1S/C25H28O6/c1-25(2,23(26)13-9-17-7-11-19(28-3)21(15-17)30-5)24(27)14-10-18-8-12-20(29-4)22(16-18)31-6/h7-16H,1-6H3/b13-9+,14-10+ |
| InChIKey | VMMZAMVBGQWOHT-UTLPMFLDSA-N |
| SMILES | COc1ccc(\C=C\C(=O)C(C)(C)C(=O)\C=C\c2ccc(OC)c(OC)c2)cc1OC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
FLLL31 price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F9057 | FLLL31 ≥98% (HPLC) | 52328-97-9 | 5mg | $125 | 2026-04-30 | Buy |
| Sigma-Aldrich | F9057 | FLLL31 ≥98% (HPLC) | 52328-97-9 | 25mg | $368 | 2026-04-30 | Buy |
| Cayman Chemical | 42233 | FLLL31 ≥98% | 52328-97-9 | 5mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 42233 | FLLL31 ≥98% | 52328-97-9 | 10mg | $196 | 2026-04-30 | Buy |
| Cayman Chemical | 42233 | FLLL31 ≥98% | 52328-97-9 | 25mg | $436 | 2026-04-30 | Buy |
FLLL31 Chemical Properties, Uses, Production
Uses
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2].
Biological Activity
Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects.
in vitro
Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.
target
| STAT3
|
IC 50
STAT3
References
[1] Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res.2010 Mar 15;70(6):2445-54. DOI:10.1158/0008-5472.CAN-09-2468
[2] Yuan S, et al. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model. Int Immunopharmacol.2014 Jul;21(1):128-36. DOI:10.1016/j.intimp.2014.04.020
FLLL31 Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
