(±)-1-Isopropyl-d7-amino-3-(1-naphthyloxy)-2-propanol hydrochloride
- CAS No.
- 1613439-56-7
- Chemical Name:
- (±)-1-Isopropyl-d7-amino-3-(1-naphthyloxy)-2-propanol hydrochloride
- Synonyms
- D7-Propranolol hydrochloride;(±)-Propranolol-(isopropyl-d7) hydrochloride;(±)-1-Isopropyl-d7-amino-3-(1-naphthyloxy)-2-propanol hydrochloride
- CBNumber:
- CB22751175
- Molecular Formula:
- C16H22ClNO2
- Molecular Weight:
- 295.81
- MDL Number:
- MFCD11983489
- MOL File:
- 1613439-56-7.mol
(±)-1-Isopropyl-d7-amino-3-(1-naphthyloxy)-2-propanol hydrochloride price More Price(1)
(±)-1-Isopropyl-d7-amino-3-(1-naphthyloxy)-2-propanol hydrochloride Chemical Properties,Uses,Production
Uses
Propranolol-d7 (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
IC 50
β adrenergic receptor
References
[1] Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. DOI:10.1124/mol.106.026716
[2] Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. DOI:10.1111/j.1476-5381.1980.tb07920.x
[3] Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. DOI:10.1016/bs.podrm.2017.02.006
(±)-1-Isopropyl-d7-amino-3-(1-naphthyloxy)-2-propanol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(±)-1-Isopropyl-d7-amino-3-(1-naphthyloxy)-2-propanol hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Artis Biotech Co. Ltd. | 19138486554 18582380095 | sales@artisbio.com | China | 1850 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2382 | 58 |
| Shanghai Moqi Biological Technology Co., LTD | 021-38218169 13341702378 | 190129269@qq.com | China | 9931 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12582 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 15102117276 19921389125 | tech@zzbioco.com | China | 12064 | 58 |
| Tanmo Quality Inspection Technology Co., Ltd. | 4008-099-669 | 23419001name@qq.com | CHINA | 6043 | 58 |
