4-Fluorobenzhydrazide
- CAS No.
- 456-06-4
- Chemical Name:
- 4-Fluorobenzhydrazide
- Synonyms
- 4-fluorobenzohydrazide;YTO*;AKOS B020279;ASISCHEM R36621;AKOS BBS-00004506;BUTTPARK 35\03-73;TIMTEC-BB SBB002375;4-FLUOROBENZHYDRAZIDE;p-Fluorobenzhydrazide;4-fluoroenzoylhydrazide
- CBNumber:
- CB2281902
- Molecular Formula:
- C7H7FN2O
- Molecular Weight:
- 154.14
- MDL Number:
- MFCD00060562
- MOL File:
- 456-06-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Fluorobenzoic hydrazide 96% | 536334 | 5g | $56.6 |
| 4-Fluorobenzohydrazide >98.0%(GC)(T) | F0540 | 5g | $130 |
| 4-Fluorobenzohydrazide >98.0%(GC)(T) | F0540 | 25g | $484 |
| 4-Fluorobenzoic hydrazide Asreported | 277916 | 10g | $333 |
| 4-Fluorobenzoic hydrazide Asreported | 277916 | 25g | $488 |
| More product size | |||
| Melting point | 162-166 °C (lit.) |
|---|---|
| Density | 1.272±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 12.17±0.10(Predicted) |
| form | Crystalline Powder |
| color | Orange to light brown |
| InChI | 1S/C7H7FN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11) |
| InChIKey | UIVXXFYJRYVRKJ-UHFFFAOYSA-N |
| SMILES | NNC(=O)c1ccc(F)cc1 |
| CAS DataBase Reference | 456-06-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DH1310000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29280000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Fluorobenzhydrazide price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 536334 | 4-Fluorobenzoic hydrazide 96% | 456-06-4 | 5g | $56.6 | 2026-04-30 | Buy |
| TCI Chemical | F0540 | 4-Fluorobenzohydrazide >98.0%(GC)(T) | 456-06-4 | 5g | $130 | 2026-04-30 | Buy |
| TCI Chemical | F0540 | 4-Fluorobenzohydrazide >98.0%(GC)(T) | 456-06-4 | 25g | $484 | 2026-04-30 | Buy |
| Usbiological | 277916 | 4-Fluorobenzoic hydrazide Asreported | 456-06-4 | 10g | $333 | 2026-06-03 | Buy |
| Usbiological | 277916 | 4-Fluorobenzoic hydrazide Asreported | 456-06-4 | 25g | $488 | 2026-06-03 | Buy |
4-Fluorobenzhydrazide Chemical Properties,Uses,Production
preparation
The synthesized ester (12.5ml) was taken into a round bottom flask (250ml), 50ml of absolute ethanol & 37.5ml of hydrazine hydrate was added in the flask. The ester, ethanol & hydrazine hydrate for the synthesis of hydrazide must be in following ratio: Ester: Absolute ethanol: Hydrazine hydrate 1 : 4 : 3 Then round bottom flask was covered with aluminium foil, placed on hot plate & allowed to stir it for almost 12-15 hrs. As the solid product appeared, reaction completion was checked by performing TLC using n-hexane, ethyl acetate & TLC cards & observed under UV lamp. After completion of reaction n-hexane was added. Solution filtered as needle like crystals appeared. Allowed it to dry & a shiny off white product was obtained that was hydrazide & product was calculated (79%).
Chemical Properties
White solid
Uses
Used in the stnthesis of fluorinated poly (1, 3, 4-oxadiazole-ether-imide). N-(3,5-dinitrobenzoyl)-N-(4-fluorobenzoyl)-hydrazine with 4-Fluorobenzhydrazide as solvent in NMP.
Synthesis
451-46-7
456-06-4
General procedure for the synthesis of 4-fluorobenzohydrazide from ethyl 4-fluorobenzoate: To a stirred solution of ethyl 4-fluorobenzoate (4.5 g, 26.7 mmol) in ethanol (30 mL) was added hydrazine hydrate (6.67 g, 133.5 mmol) at room temperature. The reaction mixture was heated to 85 °C and refluxed for 10 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The resulting solid was washed with hexane (50 mL) and dried to give 4-fluorobenzhydrazide (4.2 g, quantitative yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 9.85 (s, 1H), 7.86 (dd, 2H), 7.25 (t, 3H), 4.46 (s, 1H), 3.47 (br s, 1H).
References
[1] Patent: WO2013/49559, 2013, A1. Location in patent: Page/Page column 92
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 6014 - 6024
[3] Patent: WO2011/52516, 2011, A1. Location in patent: Page/Page column 59
[4] Journal of Nanoscience and Nanotechnology, 2013, vol. 13, # 5, p. 3321 - 3330
[5] European Journal of Medicinal Chemistry, 2010, vol. 45, # 9, p. 3943 - 3949
4-Fluorobenzhydrazide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from 4-Fluorobenzhydrazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-Fluorobenzhydrazide
456-06-4
|
$1.00 | 1G | 99% | 100KG | Career Henan Chemical Co |
-
- 4-Fluorobenzhydrazide
456-06-4
- $1.00
- 99%
- Career Henan Chemical Co
