TIMD1
- CAS No.
- Chemical Name:
- TIMD1
- Synonyms
- KIM1;TIMD1;Interleukin-35;IL-35 (mouse): FC (human);Tim-1 (human): FC (human);Mouse Interleukin 35 elisa kit;Hepatitis A virus cellular receptor 1;T-cell immunoglobulin and mucin domain-containing protein 1;T-cell immunoglobulin and mucin domain-containing protein 4
- CBNumber:
- CB22915513
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| form | lyophilized |
| color | white |
| biological source |
human mouse |
| FDA UNII | NU0AZ01G18 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
TIMD1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP8054 | Tim-1 (human): FC (human) recombinant, expressed in CHO cells, ≥98% (SDS-PAGE) | 100μG | $545 | 2026-04-30 | Buy | |
| Sigma-Aldrich | SRP8053 | IL-35 (mouse): FC (human) recombinant, expressed in CHO cells | 5μg | $592 | 2026-04-30 | Buy | |
| Usbiological | 590351 | KIM-1 PurifiedbyProteinGaffinitychromatographyfromascites. | 100ug | $1090 | 2026-06-03 | Buy | |
| Usbiological | 548133 | Interleukin 35 PurifiedbyProteinA/Gaffinitychromatography. | 200ul | $563 | 2026-06-03 | Buy | |
| Usbiological | 153168 | T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 | 96Tests | $864 | 2021-12-16 | Buy |
TIMD1 Chemical Properties, Uses, Production
Uses
IL-35 has been used to study its immunosuppressive effect on acute graft-versus-host disease in a mouse model.Ithas also been used to study its effects on the differentiation of granulocytemacrophage-colony-stimulating factor-producing T helper cells (ThGM). IL-35has been used to study its effects on bleomycin-induced pulmonary fibrosis.
Biological Activity
Regulatory T cells are essential for maintaining self tolerance and preventing autoimmunity, and IL-35 is identified as a molecule th at mediates the immune suppression function of Treg-cell. As an inhibitory cytokine, IL-35 induces proliferation of Treg-cell populations but suppresses Th17 cell development. Studies in mice show the absence of either IL-35 chain from Treg-cell reduces the cellsμ ability to suppress inflammation using an experimental model for inflammatory bowel disease. IL-35 is suggested as a potential target of immunotherapy.IL-35 is produced inresponse to agonists of toll-like receptors 3 and 4 (TLR 3 & 4) and interferon γ (IFN-γ). It is secreted mainly by activated B cells, CD4+ Foxp3+ regulatoryT cells (Tregs), and at a lower concentration by monocytes, smooth muscle cells, and endothelial cells.
TIMD1 Preparation Products And Raw materials
Raw materials
Preparation Products
TIMD1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai fantai biology science and technology co., ltd | 15601885736 | 2114786541@qq.com | China | 206 | 58 |
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 9925 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Shanghai Jinshi Biochemical Technology Co., Ltd | 18601717983 18601717983 | 291017736@qq.com | China | 499 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 8165 | 58 |
| shlmai | 021-67680335 13052188602 | sale1@shlmai.net | China | 10000 | 58 |
