2-(Trimethylsilylethynyl)pyridine
- CAS No.
- 86521-05-3
- Chemical Name:
- 2-(Trimethylsilylethynyl)pyridine
- Synonyms
- TIMTEC-BB SBB009057;TriMethylsilylethynyl)pyridin;2-(Trimethylsilyethynyl)pyridine;(2-Pyridylethynyl)trimethylsilane;2-(Trimethylsilylethynyl)pyridine;2-(Trimethlysilyl-ethynyl)pyridine;2-(Trimethylsilylethynyl)pyridine,97%;trimethyl(2-pyridin-2-ylethynyl)silane;Pyridine, 2-[2-(trimethylsilyl)ethynyl]-;Pyridine,2-[(trimethylsilyl)ethynyl]-(9CI)
- CBNumber:
- CB2295453
- Molecular Formula:
- C10H13NSi
- Molecular Weight:
- 175.3
- MDL Number:
- MFCD00066349
- MOL File:
- 86521-05-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 42 °C |
|---|---|
| Boiling point | 85 °C |
| Density | 0.95±0.1 g/cm3(Predicted) |
| refractive index | 1.5330 |
| Flash point | 85-86°C/1mm |
| storage temp. | Inert atmosphere,2-8°C |
| pka | 4.29±0.19(Predicted) |
| form | clear liquid |
| color | Colorless to Light orange to Yellow |
| Water Solubility | Insoluble in water. |
| BRN | 4176916 |
| CAS DataBase Reference | 86521-05-3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
2-(Trimethylsilylethynyl)pyridine price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3879 | 2-[(Trimethylsilyl)ethynyl]pyridine | 86521-05-3 | 1G | $33 | 2026-04-30 | Buy |
| TCI Chemical | T3879 | 2-[(Trimethylsilyl)ethynyl]pyridine | 86521-05-3 | 5G | $113 | 2026-04-30 | Buy |
| GFS CHEMICALS | 83422 | 2-(Trimethylsilylethynyl)Pyridine, 97% | 86521-05-3 | 25G | $483.48 | 2026-06-03 | Buy |
| GFS CHEMICALS | 83421 | 2-(Trimethylsilylethynyl)Pyridine, 97% | 86521-05-3 | 5G | $143.19 | 2026-06-03 | Buy |
| Apolloscientific | OR923795 | 2-(Trimethylsilylethynyl)pyridine >98% | 86521-05-3 | 250mg | $21 | 2026-06-04 | Buy |
2-(Trimethylsilylethynyl)pyridine Chemical Properties, Uses, Production
Chemical Properties
Clear colorless to yellow liquid
Uses
2-(Trimethylsilylethynyl)pyridine is used as a pharmaceutical intermediate.
Synthesis
109-04-6
1066-54-2
86521-05-3
General procedure for the synthesis of 2-pyridinylalkynyltrimethylsilanes from 2-bromopyridine and trimethylsilylethynes: 100 mL of diisopropylamine solution containing 2-bromopyridine (4.74 g, 0.030 mol), CuI (0.14 g, 0.74 mmol), and Pd(PPh3)2Cl2 (0.52 g, 0.74 mmol) was added to a solution containing 2-bromopyridine (4.74 g, 0.030 mol), CuI (0.14 g, 0.74 mmol), and Pd(PPh3)2Cl2 (0.52 g, 0.74 mmol), protected by nitrogen. trimethylsilylacetylene (3.0 g, 0.030 mol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was purified to give 5.0 g (95% yield) of 2-(trimethylsilyl)ethynylpyridine.
References
[1] Synthesis, 1983, # 4, p. 312 - 314
[2] Canadian Journal of Chemistry, 2005, vol. 83, # 6-7, p. 716 - 727
[3] Phosphorus, Sulfur and Silicon and Related Elements, 2002, vol. 177, # 5, p. 1041 - 1045
[4] Patent: WO2006/93466, 2006, A1. Location in patent: Page/Page column 28
[5] Journal of Organometallic Chemistry, 2009, vol. 694, # 9-10, p. 1317 - 1324
2-(Trimethylsilylethynyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
View Latest Price from 2-(Trimethylsilylethynyl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE
86521-05-3
|
$1.00 | 1KG | 98% HPLC | 10 tons/month | Career Henan Chemical Co |
-
- 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE
86521-05-3
- $1.00
- 98% HPLC
- Career Henan Chemical Co
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