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ChemicalBook >> CAS DataBase List >>(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime

(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime

(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime Structure
(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime structure
CAS No.
1071727-78-0
Chemical Name:
(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime
Synonyms
5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime;(E)-5H-cyclopenta[b]pyridin-7(6H)-one O-methyl oxime;(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime;5,6-dihydro-7H-cyclopenta[b]pyridin-7-oneO-methyloxime;7H-Cyclopenta[b]pyridin-7-one, 5,6-dihydro-, O-methyloxime
CBNumber:
CB23033261
Molecular Formula:
C9H10N2O
Molecular Weight:
162.19
MDL Number:
MFCD28975314
MOL File:
1071727-78-0.mol
MSDS File:
SDS
Last updated:2026-08-06 08:10:10
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(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime Properties

Boiling point 280.253±42.00 °C(Press: 760.00 Torr)(predicted)
Density 1.198±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. 2-8°C
pka 4.089±0.20(predicted)

(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA0096KM (Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime 95% 1071727-78-0 100mg $107 2026-05-28 Buy
aablocks AA0096KM (Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime 95% 1071727-78-0 250mg $174 2026-05-28 Buy
aablocks AA0096KM (Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime 95% 1071727-78-0 1g $396 2026-05-28 Buy
aablocks AA0096KM (Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime 95% 1071727-78-0 5g $1007 2026-05-28 Buy
aablocks AA0096KM (Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime 95% 1071727-78-0 10g $1653 2026-05-28 Buy
Product number Packaging Price Buy
AA0096KM 100mg $107 Buy
AA0096KM 250mg $174 Buy
AA0096KM 1g $396 Buy
AA0096KM 5g $1007 Buy
AA0096KM 10g $1653 Buy

(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime Chemical Properties, Uses, Production

Synthesis

7H-CYCLOPENTA[B]PYRIDIN-7-ONE, 5,6-DIHYDRO-

31170-78-2

Methoxyamine Hydrochloride

593-56-6

(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime

1071727-78-0

General procedure for the synthesis of (Z)-5H-cyclopenta[b]pyridin-7(6H)-one O-methyloxime from 5,6-dihydro-7H-cyclopenta[b]pyridin-7-one and methoxylamine hydrochloride: methoxylamine hydrochloride (6.20 g, 74.23 mmol) was added to a methanol solution of 5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (4.96 g. 37.25 mmol) in methanol solution followed by the addition of triethylamine (10.4 mL, 74.62 mmol). The reaction mixture was refluxed overnight, cooled to room temperature and extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, washed sequentially with water (3 x 200 mL), saturated saline (1 x 200 mL), dried over anhydrous magnesium sulfate and concentrated. Purification by column chromatography using hexane:ether (4:1) as eluent afforded 4.10 g (68% yield) of the target product (Z)-5H-cyclopentadieno[b]pyridin-7(6H)-one O-methyloxime. Spectral data: 1H NMR (300 MHz, CDCl3) δ 2.90-2.96 (m, 2H), 2.99-3.07 (m, 2H), 4.08 (s, 3H), 7.21 (q, J = 4.69, 2.93 Hz, 1H), 7.63 (d, J = 7.92 Hz, 1H), 8.55 (d, J = 4.69 Hz. 1H).

References

[1] Patent: US2008/255239, 2008, A1. Location in patent: Page/Page column 32
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 3, p. 392 - 395

(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime Preparation Products And Raw materials

Raw materials

7H-Cyclopenta[b]pyridin-7-one, 5,6-dihydro- Methoxyamine Hydrochloride Triethylamine Methanol

Preparation Products

(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime Suppliers

Global Suppliers ( 27)
Supplier Tel Email Country ProdList Advantage
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Jinan elephant international trading co., LTD 13006575422@163.com China 6347 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Taian Jiaye Biotechnology Co.Ltd 15318151873;13127280945 285424065@qq.com China 9961 55
Wuxi AppTec 022-59987777 13552403979 jia_guoqiang@wuxiapptec.com China 22344 58
Aikon International Limited 025-58859352 13913916777 dt3@aikonchem.com China 15490 58
Bejing Famous Pharmaceutical Technology Co., Ltd. 010-80339217; 13331045123 2559355526@qq.com China 14180 58
3A Chemicals 400-668-9898 service@3achem.com China 20535 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Xi'an Zhenghao Biotechnology Co., Ltd 19829389091 399787610@qq.com China 2500 58
Supplier Advantage
Cool Pharm, Ltd 58
Jinan elephant international trading co., LTD 58
Amadis Chemical Company Limited 58
Taian Jiaye Biotechnology Co.Ltd 55
Wuxi AppTec 58
Aikon International Limited 58
Bejing Famous Pharmaceutical Technology Co., Ltd. 58
3A Chemicals 58
Energy Chemical 58
Xi'an Zhenghao Biotechnology Co., Ltd 58

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(Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime (E)-5H-cyclopenta[b]pyridin-7(6H)-one O-methyl oxime 7H-Cyclopenta[b]pyridin-7-one, 5,6-dihydro-, O-methyloxime 5,6-dihydro-7H-cyclopenta[b]pyridin-7-oneO-methyloxime 5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime 1071727-78-0