ChemicalBook >> CAS DataBase List >>Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester

Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester

Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester structure

CAS No.: 99429-68-2

Chemical Name:: Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester

Synonyms: 5-ethoxycarbonyl-4-hydroxythieno<2,3-b>pyridin-6(7H)-one;Ethyl 4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylate;Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester

CBNumber:: CB23035159

Molecular Formula:: C10H9NO4S

Molecular Weight:: 239.25

MDL Number:: MFCD22741552

MOL File:: 99429-68-2.mol

MSDS File:: SDS

Last updated:2026-05-28 00:08:32

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Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester Properties

Boiling point	475.7±45.0 °C(Predicted)
Density	1.507±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	4.50±1.00(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
aablocks	AA00IK7B	Ethyl 4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylate 97.00%+	99429-68-2	250mg	$344	2026-05-29	Buy
aablocks	AA00IK7B	Ethyl 4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylate 97.00%+	99429-68-2	1g	$681	2026-05-29	Buy
ACHEMBLOCK	W170934	ethyl 4-hydroxy-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylate 95%	99429-68-2	250MG	$325	2026-05-27	Buy
ACHEMBLOCK	W170934	ethyl 4-hydroxy-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylate 95%	99429-68-2	1G	$840	2026-05-27	Buy
Crysdot	CD11000419	Ethyl 4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylate 97%	99429-68-2	1g	$386	2026-05-26	Buy

Product number	Packaging	Price	Buy
AA00IK7B	250mg	$344	Buy
AA00IK7B	1g	$681	Buy
W170934	250MG	$325	Buy
W170934	1G	$840	Buy
CD11000419	1g	$386	Buy

Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester Chemical Properties, Uses, Production

Synthesis

2-(2-ethoxycarbonyl-acetylamino)-thiophene-3-carboxylic acid methyl ester

1158651-78-5

Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester

99429-68-2

General procedure for the synthesis of ethyl 4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylate from methyl 2-(3-ethoxy-3-oxopropionamido)thiophene-3-carboxylate: to a solution of tetrahydrofuran (THF, 10.0 mL) containing the compound of Example 1a) (0.150 g, 0.55 mmol), sodium hydride ( NaH, 0.066 g, 60% dispersed in mineral oil, 1.65 mmol). The reaction mixture was stirred overnight at room temperature and subsequently quenched with ice water. The reaction mixture was extracted with ethyl acetate and the organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. Purification by fast column chromatography (eluent: 0-100% hexane solution of ethyl acetate) afforded ethyl 4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylate as a yellow solid (0.080 g, 65% yield).1H NMR (400 MHz, DMSO-d6) δ ppm: 7.24 (d, J=8.0 Hz 1H), 7.20 (d, J=8.0 Hz, 1H), 4.30 (q, J=7.1 Hz, 2H), 1.31 (t, J=7.1 Hz, 3H). Mass spectrum (electrospray positive ion mode, ES+) m/e: 240 [M+H]+.

References

[1] Patent: WO2007/136990, 2007, A2. Location in patent: Page/Page column 14
[2] Patent: WO2006/102191, 2006, A1. Location in patent: Page/Page column 62-63

Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester Preparation Products And Raw materials

Raw materials

2-(2-ethoxycarbonyl-acetylamino)-thiophene-3-carboxylic acid methyl ester Water Sodium hydride Tetrahydrofuran

Preparation Products

4-Hydroxythieno[2,3-b]pyridin-6(7H)-one

Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester Suppliers

Global Suppliers ( 12)

Supplier	Tel	Email	Country	ProdList	Advantage
BePharm Ltd	400-685-9117	market@bepharm.com	China	15081	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
MQ (shanghai) Pharmaceuticals Co., Ltd.	13761635123	sales@linyuepharm.com	China	5731	55
Aikon International Limited	025-58851090 13913916777	sales01@aikonchem.com	China	15947	58
Cool Pharm, Ltd	021-58581007 18019463053	sales@coolpharm.com	China	9999	58
Henan Weituxi Chemical Technology Co., Ltd.	0371-63284658 18135795563	3905209149@qq.com	China	9707	58
Bide Pharmatech Ltd.	400-6005915	sales@picasso-e.com	China	39662	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 17801761073	Gsiyu@solarbio.com	China	50460	58
Aladdin Scientific		tp@aladdinsci.com	United States	50068	58

Supplier	Advantage
BePharm Ltd	60
Amadis Chemical Company Limited	58
MQ (shanghai) Pharmaceuticals Co., Ltd.	55
Aikon International Limited	58
Cool Pharm, Ltd	58
Henan Weituxi Chemical Technology Co., Ltd.	58
Bide Pharmatech Ltd.	58
Beijing Solarbio Science & Tecnology Co., Ltd.	58
Aladdin Scientific	58

99429-68-2 (Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester) Related Search:

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Thieno[2,3-b]pyridine-5-carboxylic acid, 6,7-dihydro-4-hydroxy-6-oxo-, ethyl ester Ethyl 4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylate 5-ethoxycarbonyl-4-hydroxythieno<2,3-b>pyridin-6(7H)-one 99429-68-2