Adenylosuccinic acid
- CAS No.
- 19046-78-7
- Chemical Name:
- Adenylosuccinic acid
- Synonyms
- Adenylsuccinic acid;C03794;Aspartyl-AMP;aspartyl adenylate;adenylosuccnic acid;Adenylosuccinic acid;ADENYLOSUCCINIC ACID HYDRATE;adenylosuccinic acid free acid;L-Aspartic acid 4-(5'-adenylyl) ester;N-[9-(5-O-Phosphono-β-D-ribofuranosyl)-9H-purin-6-yl]-L-aspartic acid
- CBNumber:
- CB2311379
- Molecular Formula:
- C14H18N5O11P
- Molecular Weight:
- 463.29
- MDL Number:
- MFCD00082508
- MOL File:
- 19046-78-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 921.9±75.0 °C(Predicted) |
|---|---|
| Density | 2.19±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility |
DMF: 20 mg/ml DMSO: 20 mg/ml Ethanol: Partially solublePBS (pH 7.2): 10 mg/ml |
| pka | 1.86±0.10(Predicted) |
| form | powder |
| color | White to off-white |
| InChIKey | OFBHPPMPBOJXRT-VWJPMABRSA-N |
| SMILES | O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n2cnc3c(N[C@@H](CC(O)=O)C(O)=O)ncnc23 |
| FDA UNII | X1B4ZJ0IIV |
| UNSPSC Code | 12352204 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
Adenylosuccinic acid price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29696 | Adenylosuccinic Acid ≥95% | 19046-78-7 | 5mg | $87 | 2026-04-30 | Buy |
| Cayman Chemical | 29696 | Adenylosuccinic Acid ≥95% | 19046-78-7 | 10mg | $139 | 2026-04-30 | Buy |
| Cayman Chemical | 29696 | Adenylosuccinic Acid ≥95% | 19046-78-7 | 25mg | $283 | 2026-04-30 | Buy |
| Cayman Chemical | 29696 | Adenylosuccinic Acid ≥95% | 19046-78-7 | 50mg | $522 | 2026-04-30 | Buy |
| Cayman Chemical | 29696 | Adenylosuccinic Acid ≥95% | 19046-78-7 | 5 mg | $79 | 2024-03-01 | Buy |
Adenylosuccinic acid Chemical Properties, Uses, Production
Uses
Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1].
Definition
ChEBI: The N6-(1,2-dicarboxyethyl) derivative of adenosine 5'-monophosphate.
in vivo
Adenylosuccinic acid (oral administration; 3-3000 μg/mL; 6 weeks) significantly improves the features of murine DMD, it decreases the number of centronucleated fibres, lipid accumulation, connective tissue infiltration and Ca2+content of mdx tibialis anterior[1].
| Animal Model: | C57Bl/10ScSn (normal wild-type strain; Con)and C57Bl/10mdx(mdx) mice[1] |
| Dosage: | 3μg/mL, 30μg/mL, 300μg/mL, 3000 μg/mL |
| Administration: | 3μg/mL for 3 days and 30μg/mL for the next 4 days, and 300μg/mL for one week, and then 3000μg/mL for 6 weeks |
| Result: | Ameliorated the symptoms of murine duchenne muscular dystrophy. |
IC 50
Human Endogenous Metabolite
References
[1] Timpani CA, et al. Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy.Sci Rep. 2020 Jan 24;10(1):1125. DOI:10.1038/s41598-020-57610-w
[2] WAARDE A V. OPERATION OF THE PURINE NUCLEOTIDE CYCLE IN ANIMAL TISSUES[J]. Biological Reviews, 1988, 63 2: 259-298. DOI: 10.1111/j.1469-185x.1988.tb00632.x
[3] HALONEN J, NEDERGAARD J. Adenosine 5-Monophosphate Is a Selective Inhibitor of the Brown Adipocyte Nonselective Cation Channel[J]. The Journal of Membrane Biology, 2002, 14 1: 0. DOI: 10.1007/s00232-001-0184-0
[4] Y. NISHIDA T. M. Contractile effect of succinylpurines on guinea pig uterus[J]. General Pharmacology-the Vascular System, 1988, 19 2: Pages 277-279. DOI: 10.1016/0306-3623(88)90076-6
[5] JESSICA R GOODING. Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.[J]. Cell reports, 2015, 13 1: 157-167. DOI: 10.1016/j.celrep.2015.08.072
[6] TARAKA R. DONTI . Diagnosis of adenylosuccinate lyase deficiency by metabolomic profiling in plasma reveals a phenotypic spectrum[J]. Molecular Genetics and Metabolism Reports, 2016, 8: Pages 61-66. DOI: 10.1016/j.ymgmr.2016.07.007
Adenylosuccinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Adenylosuccinic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai eliv pharmaceutical Co.,Ltd. | 021-50158063 | sales@elivpharma.com | China | 480 | 58 |
| Jinan Kabotang Biological Technology Co.,Ltd. | 0531-61320525 15866703830 | figo.gao@foxmail.com | China | 7601 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8491 | 58 |
| NewCan Biotech Limited | +86-571-86912261 19975279805 | sales@newcanbio.com | China | 9984 | 58 |
View Latest Price from Adenylosuccinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Adenylosuccinic acid
19046-78-7
|
$287.00-932.00 | 10g | TargetMol Chemicals Inc. |
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- Adenylosuccinic acid
19046-78-7
- $287.00-932.00
- TargetMol Chemicals Inc.
