TRX-0237 mesylate
- CAS No.
- 1236208-20-0
- Chemical Name:
- TRX-0237 mesylate
- Synonyms
- Hydromethylthionine mesylate;Leucomethylene;Leucomethylene blue (Mesylate);CS-2892;CH3SO3H;RX-0237 mesylate;TRX-0237 mesylate;TRx0237 (LMTX) mesylate;TRX-0237 Methanesulfonate;TRX0237 (LMTX) , (CH3SO3H)
- CBNumber:
- CB23119756
- Molecular Formula:
- C16H19N3S.2(CH4O3S)
- Molecular Weight:
- 477.61848
- MDL Number:
- MFCD29764308
- MOL File:
- 1236208-20-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| solubility |
DMSO:102.5(Max Conc. mg/mL);214.61(Max Conc. mM) H2O:54.0(Max Conc. mg/mL);113.06(Max Conc. mM) |
| form | A solid |
| color | Light green to green |
| InChI | InChI=1S/C16H19N3S.2CH4O3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;2*1-5(2,3)4/h5-10,17H,1-4H3;2*1H3,(H,2,3,4) |
| InChIKey | SPCMQFLNOVTUBM-UHFFFAOYSA-N |
| FDA UNII | 3248SEF29D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
TRX-0237 mesylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 34307 | TRx0237 (mesylate) ≥95% | 1236208-20-0 | 5mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 34307 | TRx0237 (mesylate) ≥95% | 1236208-20-0 | 10mg | $105 | 2026-04-30 | Buy |
| Cayman Chemical | 34307 | TRx0237 (mesylate) ≥95% | 1236208-20-0 | 25mg | $183 | 2026-04-30 | Buy |
| Cayman Chemical | 34307 | TRx0237 (mesylate) ≥95% | 1236208-20-0 | 50mg | $303 | 2026-04-30 | Buy |
| ChemScene | CS-5553 | Leucomethylene blue mesylate 98.06% | 1236208-20-0 | 5mg | $65 | 2026-06-04 | Buy |
TRX-0237 mesylate Chemical Properties, Uses, Production
Uses
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes[1][2][3].
Biological Activity
TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor. For the treatment of Alzheimer's disease and frontotemporal dementia.
in vitro
TRx 0237 (LMTX) is a second-generation tau aggregation inhibitor for the treatment of Alzheimer's disease and frontotemporal dementia. It is a purified form of methylene blue, an ancient drug widely used in Africa to treat malaria and methemoglobinemia. In vitro experiments demonstrated that 0.16 μM TRx 0237 interfered with double helical filaments (PHF) isolated from Alzheimer's disease patient brain tissue.
in vivo
TRX-0237 mesylate dose-dependently rescues learning impairment in L1 (a mouse strain overexpressing truncated tau protein) and restores its behavioral resilience in the water maze test (minimum dose administered: 9 mg MT/kg). In L66 (a mouse strain overexpressing full-length tau-P301S/G335D), it modulates its motor learning (effective dose: 4 mg MT/kg). It reduced the number of tau-active neurons, especially in the hippocampus and entorhinal cortex of L1, and more generally in the L66 strain.
target
| Target | Value |
| tau protein aggregation |
References
[1] Gaudette NF, et al. Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine andB6C3F1 mouse urine. J Anal Toxicol. 2005 Jan-Feb;29(1):28-33. DOI:10.1093/jat/29.1.28
[2] Zhenhua Liu, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. Int J Mol Med. 2019 Jan;43(1):435-442. DOI:10.3892/ijmm.2018.3935
[3] Francesco Panza, et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy Expert Opin Pharmacother. 2016;17(4):457-61. DOI:10.1517/14656566.2016.1146686
TRX-0237 mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| Suzhou Shentuo Pharmaceutical Technology Co., Ltd | 13911244683 18151949202 | info@visonpharma.com | China | 491 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
View Latest Price from TRX-0237 mesylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Leucomethylene blue mesylate
1236208-20-0
|
$68.00-526.00 | 97.47% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-22 | CH3SO3H
1236208-20-0
|
1KG | 95%-99% | 1kg; 5kg; 10kg | Career Henan Chemica Co |
-
- Leucomethylene blue mesylate
1236208-20-0
- $68.00-526.00
- 97.47%
- TargetMol Chemicals Inc.
-
- CH3SO3H
1236208-20-0
- $0.01
- 95%-99%
- Career Henan Chemica Co
